Detection of Homocysteine with Bridged Viologen Chemical Probes

Abstract

Increased blood plasma concentrations of the aminothiol homocysteine (Hcy) are associated with a variety of disease states including those which cause impaired renal function, many forms of cardiovascular disease, and neurodegenerative diseases such as Alzheimer's. Therefore, Hcy has the potential to be a significant diagnostic biomarker.Routine monitoring of Hcy plasma concentration is encumbered by the time and resources required to quantify Hcy using currently accepted instrumental analysis methods. As part of the continuing effort to develop a quick, reliable, inexpensive, and user-friendly test to quantify Hcy at the point of care, we have designed a series of novel iii Acknowledgements

Folic acid incorporated nitrogen‐doped carbon dots as a turn‐on fluorescence probe for homocysteine detection

“…[ 9–12 ] Several clinical studies assessed the effect of high concentration at different stages of CVD ranging from atherosclerosis to stroke or myocardial infarction. [ 11–14 ]…”

“…[9][10][11][12] Several clinical studies assessed the effect of high concentration at different stages of CVD ranging from atherosclerosis to stroke or myocardial infarction. [11][12][13][14] The traditional methods of Hcy detection include chromatographic techniques like gas chromatography (GC), high-performance liquid chromatography (HPLC), capillary electrophoresis, etc., which are tedious, expensive, and confined to centralized laboratories. [6] Another major challenge during the detection of Hcy is the interference caused by its sister homologue cysteine, which differs only by a single methylene group.…”