Detection of IgE-mediated respiratory sensitization in workers exposed to hexahydrophthalic anhydride

Toxicokinetics and biological monitoring in experimental exposure of humans to gaseous hexahydrophthalic anhydride.

“…Hexahydrophthalic anhydride (HHPA) is an irritant to the eyes and the mucous membranes of the respiratory tract (I) and has been reported to cau se occupational asthma and allergic rhinitis (2). Furthermore , HHPA causes allergic sensitization in a large fraction of exposed workers, even at extremely low exposure levels (3).…”

Hexahydrophthalsäureanhydrid/Methyltetrahydrophthalsäureanhydrid [MAK Value Documentation in German language, 1995]

“…Hexahydrophthalsäureanhydrid führt bei exponierten Arbeitern zu Asthma, Rhinitis, Nasen-und Augenbeschwerden. In mehreren Untersuchungen wurden erhöhte spezifische IgE-Antikörperspiegel nachgewiesen (Grammer et al 1994;Moller et al 1985;Schöneich und Wallenstein 1991). Bei 23/95 Arbeitern aus Hexahydrohpthalsäureanhydrid-verarbeitenden Betrieben waren im Radio-Allergen-Sorbent-Test (RAST) in unterschiedlichen Expositionsgruppen ( � 10 Vg Hexahydrophthalsäure-anhydrid /m 3 , 10-50 Vg/m 3 , � 50 Vg/m 3 ; mittlere Expositionszeit 7 Jahre) die spezifische IgE-Antikörperspiegel signifikant gegenüber der Kontrollgruppe erhöht.…”

Total plasma protein adducts of allergenic hexahydrophthalic and methylhexahydrophthalic anhydrides as biomarkers of long-term exposure

“…They are also known to be extremely powerful occupational allergens. Symptoms of diseases such as asthma, rhinitis, and conjunctivitis have been found in up to two-thirds of exposed workers (1)(2)(3). Specific immunoglobulin (Ig) E against conjugates between an anhydride and human serum albumin (HSA) have been found to be present in more than 60% of exposed workers (4).…”