Detection of oncogenes in chronic pancreatitis

Paramythiotis, Daniel; Kleeff, Jörg; Schmidt, Jan; Büchler, Markus W.; Frieß, Helmut

doi:10.1080/13651820310017804

Cited by 3 publications

(2 citation statements)

References 106 publications

(166 reference statements)

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“…This suggests that there is interplay between Kras activation and the inflammatory cascade (possibly through cytokines) that enhances the risk of malignant transformation in the pancreas. Activating mutations in Kras have been identified in the pancreatic juice and tissues from CP cases [79]. It would be of interest to examine whether patients with CP who have mutations in Kras and develop recurrent attacks of pancreatitis are at an accelerated risk of developing invasive adenocarcinoma.…”

Section: Risk Factors and Their Role In Pancreatic Cancer Screeninmentioning

confidence: 99%

Current status of molecular markers for early detection of sporadic pancreatic cancer

Chakraborty

Baine

Sasson

et al. 2011

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Pancreatic cancer (PC) is a highly lethal malignancy with near 100% mortality. This is in part due to the fact that most patients present with metastatic or locally advanced disease at the time of diagnosis. Significantly, in nearly 95% of PC patients there is neither an associated family history of PC nor of diseases known to be associated with an increased risk of PC. These groups of patients who comprise the bulk of PC cases are termed as "sporadic PC" in contrast to the familial PC cases that comprise only about 5% of all PCs. Given the insidious onset of the malignancy and its extreme resistance to chemo and radiotherapy, an abundance of research in recent years has focused on identifying biomarkers for the early detection of PC, specifically aiming at the sporadic PC cohort. However, while several studies have established that asymptomatic individuals with a positive family history of PC and those with certain heritable syndromes are candidates for PC screening, the role of screening in identifying sporadic PC is still an unsettled question. The present review attempts to assess this critical question by investigating the recent advances made in molecular markers with potential use in the early diagnosis of sporadic PC-the largest cohort of PC cases worldwide. It also outlines a novel yet simple risk-factor based stratification system that could be potentially employed by clinicians to identify those individuals who at an elevated-risk for the development of sporadic PC and therefore candidates for screening. Keywords diagnosis; PanIN; biomarkers PrologueIt seems that pancreatic cancer (PC) has recently crept further and further into the consciousness of the general public. The news that Luciano Pavarotti, the renowned opera Address for Correspondence: Surinder K. Batra, Ph.D., Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-5870, U.S.A., Phone: 402-559-5455; Fax: 402-559-6650. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptBiochim Biophys Acta. Author manuscript; available in PMC 2012 January 1. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript singer and one of the legendary "three tenors" had been diagnosed with PC came as a shock to millions of his followers the world over. A year-and-a-half later, the famous actor and heartthrob, Patrick Swayze, also received the diagnosis of PC and succumbed to his disease in just 19 months. Former United States...

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Section: Risk Factors and Their Role In Pancreatic Cancer Screeninmentioning

confidence: 99%

Current status of molecular markers for early detection of sporadic pancreatic cancer

Chakraborty

Baine

Sasson

et al. 2011

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

View full text Add to dashboard Cite

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“…The main symptoms of CP are malnutrition, steatorrhea and abdominal pain, since exocrine and endocrine insufficiency 3-5. According to the initiating causes, it could be subtyped to Alcoholic chronic pancreatitis, Hereditary chronic pancreatitis, Cystic fibrosis-associated chronic pancreatitis, Tropical pancreatitis, Autoimmune chronic pancreatitis, Biliary-associated chronic pancreatitis, Idiopathic chronic pancreatitis and some other forms 6, 7.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Study Indicates PRSS1 Gene Is Significantly Associated with Pancreatitis

Liu

2013

Int. J. Med. Sci.

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This comprehensive meta-analysis was applied to case-control studies of the association between pancreatitis and PRSS1 gene to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. PubMed, EMBASE, and Cochrane Library were searched in order to identify longitudinal studies evaluating pancreatitis disease and PRSS1 gene. Odds ratios (ORs) were pooled using a random-effects model. For the case-control studies, the authors found 1) support for the association between total pancreatitis and PRSS1 gene, both totally analyzed and subdivided analyzed {total: [OR:10.799, 95%CI:(5.489-21.242), p<0.000]; Europe: [OR:9.795, 95%CI:(2.923-32.819), p<0.000]; Asia: [OR:11.994, 95%CI:(5.156-27.898), p<0.000]}. 2) no evidence showed that this association was accounted for by any one study, and 3) no evidence showed any publication bias exist. In conclusion, PRSS1 gene was significantly associated with total pancreatitis disease, both totally and separately.

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Identification and Validation of Src and Phospho-Src Family Proteins in Circulating Mononuclear Cells as Novel Biomarkers for Pancreatic Cancer

Yokoi

Hawke

Oborn

et al. 2011

Translational Oncology

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There is an urgent need to develop novel markers of pancreatic cancer to facilitate early diagnosis. Pancreatic carcinoma is characterized by marked stroma formation with a high number of infiltrating tumor-associated macrophages (TAMs) that originate from circulating mononuclear cells (MNCs). We hypothesized that differential analysis of protein expression and phosphorylation in circulating MNCs from healthy nude mice and nude mice bearing orthotopic human pancreatic cancer would identify a surrogate marker of pancreatic cancer. These differences were analyzed by two-dimensional gel electrophoresis followed by Western blot analysis using antibody against phosphorylated tyrosine proteins (pY). Protein and phosphorylated protein spots of interest were identified by mass spectrometry and validated by Western blot analysis as candidate markers for pancreatic cancer. We found that the expression and phosphorylation of Src family proteins were significantly higher in circulating MNCs from mice bearing pancreatic cancer than in circulating MNCs from healthy mice. TAMs in mice with pancreatic tumors also had higher Src family protein expression and phosphorylation than resident macrophages in the pancreas of healthy mice. The expression and phosphorylation of Src family proteins were correlated with tumor weight; however, increased Src expression and phosphorylation also occurred in MNCs from mice with chronic pancreatitis. This is the first report to explore novel pancreatic tumor markers in circulating MNCs. Although the specificity of the marker for pancreatic cancer was low, it could be used to monitor the disease or to select high-risk patients with chronic pancreatitis.

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Detection of oncogenes in chronic pancreatitis

Cited by 3 publications

References 106 publications

Current status of molecular markers for early detection of sporadic pancreatic cancer

Current status of molecular markers for early detection of sporadic pancreatic cancer

A Comprehensive Study Indicates PRSS1 Gene Is Significantly Associated with Pancreatitis

Identification and Validation of Src and Phospho-Src Family Proteins in Circulating Mononuclear Cells as Novel Biomarkers for Pancreatic Cancer

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