Detection of ribavirin in environmental and biological samples via optical chemical sensor

Abstract

This study was conducted to determine the Ribavirin in Environmental and Biological Samples via Optical Chemical Sensor. In this paper, a new magnetic metal-organic framework Fe O @Fe-ASB was synthesized 3 4 with nano-Fe O as metal center and a new Schiff base, which was synthesized from quinoline-2-3 4 formaldehyde and β-mercaptoethylamine, as ligand, This Fe O @Fe-ASB was characterized by FITR, SEM 3 4 and XRD. Its enzyme-like activity was characterized by the chromogenic substrate (H O and TMB) and 2 2 verified based on the Michaelis-Menten equation. The results showed that the synthesis of Fe O @Fe-ASB was successful and it exhibited excellent 3 4 enzyme-like activity. The Fe O @Fe-ASB was successfully used for the detection of ribavirin in water 3 4 samples as catalytic material. It showed good stability, accuracy and precision. This testing method features a graph, which plots concentration (c) on the x-axis and absorption A on the y-axis to create a linear ribavirin-4-1-6-1 equation. It shows a good linear relation ranging from 1×10 mol l to 1×10 mol l , with a limit detection of-7-1 2×10 mol l. The mean recovery rates for spike recovery experiments varied from 92.0 % to 109 %. A new Schiff base was synthesized from quinoline-2-formaldehyde and βmercaptoethylamine. Then, a new magnetic metal-organic framework Fe O @Fe-ASB was synthesized by 3 4 it with nano-Fe O as the metal center. The Fe O @Fe-ASB was successfully used for the detection of 3 4 3 4 ribavirin in water samples as catalytic material. It showed good stability, accuracy and precision. Catalyst, Feed, Optical chemical sensor, Ribavirin Detection of ribavirin in environmental and biological samples via optical chemical sensor

A simplified molecularly imprinted ECL sensor based on Mn2SnO4 nanocubes for sensitive detection of ribavirin

“…Compared to the conventional enzyme-linked immunosorbent assay, 7 high-performance liquid chromatography, 8 colorimetry, 9 and aptamer-based assays, 10 electrochemiluminescence (ECL) sensors have drawn wide attention due to their simplicity, fast response, good repeatability, and high sensitivity. In a typical ECL process, a luminescent probe is excited to an excited state under a certain applied voltage and emits light when returning to its ground state.…”

Construction of a piezoelectric immunosensor for ultra-sensitive and highly selective detection of ribavirin in animal-derived foods

“…13 Therefore, in this work, we combined an immunological method and piezoelectric quartz crystal microbalance (QCM), that is, we connected the carboxyl-modified gold electrode with the amino-modified ribavirin antigen (BSA-RBV) to obtain a sensor that competes with ribavirin for the corresponding antibody (RBV-Ab), and established an ultra-sensitive and highly selective detection method. Compared with the existing methods, such as high performance liquid chromatography (HPLC), 14 liquid chromatography-mass spectrometry (LC-MS), 15 immunoassay, 6,16 electrochemical methods, 17 electrochemiluminescence, 18 colorimetry, 19 the aptamer method, 20 and capillary electrophoresis, 21,22 the piezoelectric immunosensing method has the characteristics of simple device, high sensitivity, rapid detection, simple operation, etc. , and has been widely developed in the detection field.…”