Determinants of Early Atherosclerosis in Obese Children and Adolescents

Beauloye, Véronique; Zech, Francis; Mong, H. Tran Thi; Clapuyt, Philippe; Maes, Marc; Brichard, Sonia

doi:10.1210/jc.2007-0619

Cited by 181 publications

(176 citation statements)

References 38 publications

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“…Similarly FBS was also higher in the overweight/obese group although no subject fulfilled criteria for diagnosis of diabetes. Similar observations have been made in different studies in children and indicate the presence of risk factors for metabolic syndrome in obese children [19,22].…”

Section: Correlation Between Hscrp and Other Parameterssupporting

confidence: 89%

Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

Dayal

Jain

Attri

et al. 2014

JCDR

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Context: High senstivity C-reactive protein (hsCRP) levels correlate well other parameters of obesity related metabolic syndrome (MS) and can be used as predictors of future cardiovascular disease risk. There is limited data on hsCRP levels in Indian children with simple obesity. Aim:To study the relationship of hsCRP levels with various anthropometric as well as metabolic parameters in children with simple overweight and obesity. Materials and Methods:This case control study was conducted in Paediatric Endocrinology clinic of a tertiary care hospital in Northern India. Levels of hsCRP were estimated in 100 overweight and obese children (BMI between 85 th and 95 th percentiles according to age & gender specific CDC 2000 growth charts) aged between 6 and 16 years and in 100 nearly age and sex matched healthy controls. These levels were then correlated to various anthropometric (body mass index, BMI; waist circumference, WC; hip circumference, HC; waist hip ratio, WHR; blood pressure) and biochemical (fasting blood glucose, FBG; total cholesterol, TC; high-density lipoproteincholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; very low-density lipoprotein-cholesterol, VLDL-C; triglycerides, TG) parameters.Results: Mean levels of hsCRP were significantly higher in the study group (3.92±2.20 versus 2.15±1.05 mg/L) as compared to controls. Significantly more (58% versus 10%) subjects in the study group had hsCRP (>3 mg/L). Of all the parameters studied, only BMI showed a positive correlation with hsCRP levels in the study group. Multiple logistic regression analysis for predicting outcome of high hsCRP showed positive correlation with BMI; with every 1 kg/m 2 increase in BMI, odds of high hsCRP level were increased by 37% (OR=1.37; 95% CI 1.23-1.53, p-value <0.0001). Mean values of all the biochemical parameters except HDL-C were significantly higher in the study group.Conclusion: Levels of hsCRP were significantly elevated in overweight and obese children as compared to non-obese children. In addition, these patients also showed abnormalities of lipid and glucose metabolism.

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Section: Correlation Between Hscrp and Other Parameterssupporting

confidence: 89%

Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

Dayal

Jain

Attri

et al. 2014

JCDR

View full text Add to dashboard Cite

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“…Another finding of great value in this investigation was a negative correlation between change in HOMA-IR and changes in adiponectin concentration. Beauloye et al 6 showed a negative correlation between adiponectin and carotid IMT in children and adolescents, but only at baseline conditions. These results reinforce the importance of adopting strategies that promote an improvement of HOMA-IR and adiponectinemia, which could influence IMT measurements.…”

Section: Discussionmentioning

confidence: 97%

“…Adiponectin may be more closely related to atherosclerosis in obese children than are conventional cardiovascular risk factors and inflammation status. 6 For example, it has been demonstrated that high adiponectin concentration can suppress the development of atherosclerosis in susceptible mice. 32 Consistent with this hypothesis, our study verified a negative correlation between change in HOMA-IR and change in adiponectin concentration.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of research shows that the increase in IMT in obese individuals is influenced by plasma lipid concentration, hypertension, inflammatory state, physical inactivity and impaired glucose metabolism. [5][6][7] Among these precursors, insulin resistance seems to be a strong risk factor for the development of atherosclerosis. The negative correlation between insulin resistance and adiponectin may serve as a link between obesity and atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

“…4,9,10 The prevalence of cardiovascular diseases in children and adolescents is increasing, and there is evidence that carotid IMT is higher in children with diabetes, hypercholesterolemia and obesity than in healthy controls. 4,5,6,11 Some studies of the effects of exercise training, either associated with dietary changes or alone, showed that weight loss and physical exercise decrease insulin resistance and improve endothelial dysfunction in adults. 12,13 However, few studies have investigated the effects of 1 year of interdisciplinary intervention in this parameter in obese adolescents.…”

Section: Introductionmentioning

confidence: 99%

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Improvement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss program

et al. 2010

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The aim of this study was to verify whether a 1-year interdisciplinary weight-loss program improved common carotid artery intima-media thickness (IMT) and whether insulin resistance and/or inflammation (as measured by the markers plasminogen activator inhibitor type-1 and adiponectin) might underlie obesity in adolescents. A group of 29 post-pubescent obese adolescents were submitted to an interdisciplinary intervention over the course of 1 year. Common carotid artery IMT was determined ultrasonographically. Body composition, blood pressure (BP), glycemia, insulinemia, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile and adipokine concentrations were analyzed before and after the intervention. The interdisciplinary weight-loss program promoted a significant improvement in body composition, insulin concentration, HOMA-IR, lipid profile, BP and inflammatory state, in addition to significantly decreasing the common carotid artery IMT. Furthermore, this study demonstrated that the difference between baseline and final values of HOMA-IR (DHOMA-IR) was negatively correlated with concomitant changes in the adiponectin concentration (Dadiponectin; r¼À0.42; P¼0.02) and positively correlated with changes in common carotid artery IMT (Dcarotid IMT; r¼0.41; P¼0.03). Multiple regression analysis adjusted by age, cardiovascular risk factors and inflammatory markers showed that DHOMA-IR was an independent predictor of significant changes in common carotid artery IMT. This investigation demonstrated that an interdisciplinary weight-loss program promoted a reduction of the common carotid artery IMT in obese Brazilian adolescents, and the improvement of HOMA-IR was an independent predictor of carotid IMT changes in this population.

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Childhood Obesity

Chief

2009

Brook's Clinical Pediatric Endocrinology

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Determinants of Early Atherosclerosis in Obese Children and Adolescents

Abstract: Adiponectin more than conventional CV risk factors and inflammation status may be related to early atherosclerosis in obese children.

Cited by 181 publications

References 38 publications

Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

Improvement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss program

Childhood Obesity

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