Determinants of overall quality of life in secondary progressive MS: A longitudinal study

Abstract

Twenty-nine patients with secondary progressive MS underwent monthly assessment with Expanded Disability Status Scale (EDSS), MS Functional Composite (MSFC), MS Quality of Life-54, and cranial MRI over 6 months. Overall quality of life (OQOL) correlated highly with emotional well-being, the mental health composite, health distress, and the physical health composite. In contrast, there was no statistical evidence of consistent correlation between OQOL and EDSS, MSFC, or MR outcome measures.

Disease adaptation may have decreased quality-of-life responsiveness in patients with chronic progressive neurological disorders

“…First, they are used in instruments based on two-factor models in which high correlations are seen between PH and HS and between MH and QOL. Second, in a study of response shift in prostate cancer, the mental component subscore (MCS) of the SF-12 was used as a proxy for QOL [50], and O'Connor et al [51] in a study of patients with chronic progressive multiple sclerosis noted a high correlation (0.636; P Ͻ .001) between changes in QOL and MH over 6 months (unfortunately, they did not directly study the differential responsiveness of QOL and HS).…”

Quality of life in multiple sclerosis

“…Der Nutzwert (utility), ausgedrückt zwischen  (= völlig gesund) und 0 (= tot), multipliziert mit der durch eine Therapie Bewertung der Aussagen nach 0 = "stimmt gar nicht" bis 4 = "sehr zutreffend" gewonnene Lebenszeit ergibt den QUALY [34,45]. [67]. Patienten mit relativ stabiler aber eingeschränkter körperlicher Funktionsfähigkeit -wie es bei vielen Patienten mit chronisch progredientem Verlauf der Fall ist -bewerteten ihre körper-liche Rollenfunktion im SF-36 besser als bei schubförmig remittierendem Verlauf [23].…”

“…Dies ist besonders wichtig, da Ärzte im Alltag grundsätzlich dazu tendieren, körperli-che Maßstäbe (z. B. EDSS) und LQ gleichzusetzen [67,82]. Dies erklärt wohl zum Teil die zunächst unerwarteten Ergebnisse hinsichtlich der LQ bei durchaus objektiv "erfolgreichen" immunologischer [8,62] wie auch symptomatischer Therapien [7, 5].…”

Longitudinal variations and predictors of increased perceived impact of multiple sclerosis, a two-year study

“…Few patient-based longitudinal studies on general health status in PwMS have been performed [1,21,22,24,25]. The MSIS-29 has been scarcely employed in longitudinal studies [21,22,25] and few studies have used the MSIS-29 to identify predictors of the perceived impact of MS [25,26].…”