Determination of -2-hydroxyglutaric acid in urine samples using enantioselective, potentiometric membrane electrodes based on antibiotics

Enantioseparation of d,l-2-hydroxyglutaric acid by capillary electrophoresis with tandem mass spectrometry—Fast and efficient tool for d- and l-2-hydroxyglutaracidurias diagnosis

“…Several works using the enantioselective potentiometric membrane electrodes based on maltodextrins [29] for selective determination of l-2-HG in the presence of d-2-HG in nanomolar level or vice versa with a membrane based on macrocyclic antibiotics for selective determination of d-HG in presence of l-HG [30] have been also published.…”

Maltodextrins Based Solid Membranes for the Enantioanalysis of L-Cysteine

“…Variations in DE values result in maltodextrins with varying physico-chemical properties: solubility, hydroscopicity, osmolality and their effectiveness to reduce the freezing point increase with increasing DE, while viscosity, cohesiveness and coarse-crystal prevention increase as DE decreases [23,24]. Maltodextrins were used as chiral selectors for enantiomeric separations by capillary zone electrophoresis [21,22,[25][26][27][28][29], and they were also used for the design of enantioselective, potentiometric membrane electrodes [19,[30][31][32][33]. Although, the HPLC *Address correspondence to this author at the Laboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021, Bucharest, Romania; Tel: +40751507779; E-mail: iustinavanstaden@yahoo.com (standard method) method, and fluorescence based method are highly used for biomedical analysis, they cannot always be high reliable especially for urine samples, when the complexity of the sample is very high.…”

An enantioselective polyaniline-coated membrane electrode based on chiral salen Mn(iii) as chiral selector

“…Recently, voltammetry electrochemical methods were introduced for the determination of optical active compounds using chiral solvents and supporting electrolytes, 6,7 electrodes with a chiral surface 8 and inorganic materials. 9 Enantioselective potentiometric sensors have been addressed based on chiral selectors, such as cyclodextrins, 10 maltodextrins, 11,12 crown ethers and macrocyclic antibiotics, in which the enantio-recognition mechanism was mainly due to ''three points binding'' and ''lock and key'' rules.…”