Determination of a Tolerable Daily Intake of DDT for Consumers of DDT Contaminated Fish from the Lower Yakima River, Washington*

Mariën, Koenraad; Laflamme, Denise M.

doi:10.1111/j.1539-6924.1995.tb01343.x

Cited by 10 publications

(6 citation statements)

References 34 publications

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“…OEHHA (2012) suggests calculating exposure from mother’s milk pathway only during the first year of the 0–2-year age group, with a daily exposure frequency. To estimate the breast milk lipid concentration of ΣDDT, a method based on the observed relationship between daily intake of ΣDDT and body fat concentration in humans was used (Mariën and Laflamme, 1995). This equation relies on the observed relationship by Durham et al (1965) from human data in which the ratio of ΣDDT concentration in adipose tissue and breast milk lipid concentration is 1:1, thus deriving a linear algorithm (equation 3) for breast milk lipid concentration of ΣDDT.…”

Section: 0 Methodsmentioning

confidence: 99%

“…Where BMI bw is the daily breast-milk ingestion rate of a “fully-breast-fed” infant (kg-milk/kg BW/day; 0.101 and 0.139 median and 95 th percentile, respectively) (OEHHA, 2012) and PMF is percent milk fat in breast milk (4%; unitless) (Mariën and Laflamme, 1995). Thus, based on the calculated concentration of ΣDDT in White croaker using the Bao et al (2013) IDM method (1.3x10 −5 mg/g in fish muscle tissue), the infant daily intake would be 3.4 x10 −4 and 9.8 x10 −4 mg/kg-day-BW for the median and 95 th percentile, respectively.…”

Section: 0 Methodsmentioning

confidence: 99%

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Comparisons of field and laboratory estimates of risk of DDTs from contaminated sediments to humans that consume fish in Palos Verdes, California, USA

Coffin

Gan

Schlenk

2017

Science of The Total Environment

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Calculating risk from seafood exposure to persistent organic pollutants continues to be problematic as estimates of exposure from diet require extensive monitoring of fish species and limited assessments of bioavailability from sediments where the contaminants tend to reside. Previous studies in our laboratory utilized a laboratory-based isotope dilution method (IDM) to estimate the bioavailability of DDT [1,1,1-trichloro-2, 2-bis(p-chloro-phenyl)ethane] and its metabolites from sediment to biota from a superfund site on the shelf of the Palos Verdes (PVS) Peninsula in California (USA). Using a biota-sediment accumulation factor (BSAF) derived from IDM and biomagnification factors (BMF) calculated from previous studies as well as seafood-consumption data specific to anglers in the PVS area, we estimated cancer and non-cancer risks for anglers and nursing infants representing sensitive groups. Predicted cancer risks from consumption of White Croaker (Genyonemus lineatus) to the 50th and 95th percentile to all shore mode anglers were, respectively, 2x10−7 and 7x10−7, which were similar to field studies using fish concentrations of all DDT isomers and their environmental degradates (ΣDDT) from collected animals. The calculated non-cancer hazard quotient values for the 50th and 95th percentile shore mode anglers consuming White croaker from this study (0.008 and 0.023, respectively) were also of similar magnitude as those obtained from studies based on samples obtained solely from fish. For nursing infants, similar results were also observed. These results indicate that estimates of bioavailability using IDM from sediment could be used accurately to determine risk to ΣDDT in humans from fish consumption.

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Section: 0 Methodsmentioning

confidence: 99%

Section: 0 Methodsmentioning

confidence: 99%

Comparisons of field and laboratory estimates of risk of DDTs from contaminated sediments to humans that consume fish in Palos Verdes, California, USA

Coffin

Gan

Schlenk

2017

Science of The Total Environment

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“…Predicted peak concentrations, time to impact, and resiliency of the affected system are also estimated. This metric is also termed “Degree of Vulnerability.” ( 37,61 ) Consequence Potential. This parameter represents the combination of the first two parameters (the probability of a resource being present and the probability of damage).…”

Section: Issues Unique To Native American Communitiesmentioning

confidence: 99%

“…Predicted peak concentrations, time to impact, and resiliency of the affected system are also estimated. This metric is also termed “Degree of Vulnerability.” ( 37,61 )…”

Section: Issues Unique To Native American Communitiesmentioning

confidence: 99%

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Ecological Information Needs for Environmental Justice

et al. 2010

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The concept that all peoples should have their voices heard on matters that affect their well-being is at the core of environmental justice (EJ). The inability of some people of small towns, rural areas, minority, and low-income communities, to become involved in environmental decisions is sometimes due to a lack of information. We provide a template for the ecological information that is essential to examine environmental risks to EJ populations within average communities, using case studies from South Carolina (Savannah River, a DOE site with minority impacts), Washington (Hanford, a DOE site with Native American impacts), and New Jersey (nonpoint, urbanized community pollution). While the basic ecological and public health information needs for risk evaluations and assessments are well described, less attention has been focused on standardizing information about EJ communities or EJ populations within larger communities. We suggest that information needed about EJ communities and populations includes demographics, consumptive and nonconsumptive uses of their regional environment (for example, maintenance and cosmetic, medicinal/religious/cultural uses), eco-dependency webs, and eco-cultural attributes. A purely demographics approach might not even identify EJ populations or neighborhoods, much less their spatial relation to the impact source or to each other. Using information from three case studies, we illustrate that some information is readily available (e.g., consumption rates for standard items such as fish), but there is less information about medicinal, cultural, religious, eco-cultural dependency webs, and eco-cultural attributes, all of which depend in some way on intact, functioning, and healthy ecosystems.

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Modeling the dynamics of DDT in a remote tropical floodplain: indications of post-ban use?

Mendez

Torres

et al. 2015

Environ Sci Pollut Res

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Significant knowledge gaps exist regarding the fate and transport of persistent organic pollutants like dichlorodiphenyltrichloroethane (DDT) in tropical environments. In Brazil, indoor residual spraying with DDT to combat malaria and leishmaniasis began in the 1950s and was banned in 1998. Nonetheless, high concentrations of DDT and its metabolites were recently detected in human breast milk in the community of Lake Puruzinho in the Brazilian Amazon. In this work, we couple analysis of soils and sediments from 2005 to 2014 at Puruzinho with a novel dynamic floodplain model to investigate the movement and distribution of DDT and its transformation products (dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD)) and implications for human exposure. The model results are in good agreement with the accumulation pattern observed in the measurements, in which DDT, DDE, and DDD (collectively, DDX) accumulate primarily in upland soils and sediments. However, a significant increase was observed in DDX concentrations in soil samples from 2005 to 2014, coupled with a decrease of DDT/DDE ratios, which do not agree with model results assuming a post-ban regime. These observations strongly suggest recent use. We used the model to investigate possible re-emissions after the ban through two scenarios: one assuming DDT use for IRS and the other assuming use against termites and leishmaniasis. Median DDX concentrations and p,p'-DDT/p,p'-DDE ratios from both of these scenarios agreed with measurements in soils, suggesting that the soil parameterization in our model was appropriate. Measured DDX concentrations in sediments were between the two re-emission scenarios. Therefore, both soil and sediment comparisons suggest re-emissions indeed occurred between 2005 and 2014, but additional measurements would be needed to better understand the actual re-emission patterns. Monte Carlo analysis revealed model predictions for sediments were very sensitive to highly uncertain parameters associated with DDT degradation and partitioning. With this model as a tool for understanding inter-media cycling, additional research to refine these parameters would improve our understanding of DDX fate and transport in tropical sediments.

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Determination of a Tolerable Daily Intake of DDT for Consumers of DDT Contaminated Fish from the Lower Yakima River, Washington*

Cited by 10 publications

References 34 publications

Comparisons of field and laboratory estimates of risk of DDTs from contaminated sediments to humans that consume fish in Palos Verdes, California, USA

Comparisons of field and laboratory estimates of risk of DDTs from contaminated sediments to humans that consume fish in Palos Verdes, California, USA

Ecological Information Needs for Environmental Justice

Modeling the dynamics of DDT in a remote tropical floodplain: indications of post-ban use?

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