Determination of acute oral toxicity of glyphosate isopropylamine salt in rats

Türkmen, Ruhi; Doğan, İlkay

doi:10.1007/s11356-020-07643-5

Cited by 10 publications

(1 citation statement)

References 18 publications

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“…It has been observed that administration of developed hydrogels did not alter any of above biochemical parameters to toxic level. All of them were present in normal reference range (Tan et al, 2013;Uma et al, 2013;Turkmen and Dogan, 2020).…”

Section: Biochemical Blood Analysismentioning

confidence: 90%

β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation

et al. 2021

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Section: Biochemical Blood Analysismentioning

confidence: 90%

β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation

et al. 2021

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Xylopia aethiopica suppresses markers of oxidative stress, inflammation, and cell death in the brain of Wistar rats exposed to glyphosate

Adewale

Adebisi

Ojurongbe

et al. 2023

Environ Sci Pollut Res

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Background: The herbicide "Roundup" is used extensively in agriculture to control weeds. However, by translocation, it can be deposited in plants, their proceeds, and in the soil, thus provoking organ toxicities in exposed individuals. Neurotoxicity among others is one of the side effects of roundup which has led to an increasing global concern about the contamination of food by herbicides. Xylopia aethiopicais known to have medicinal properties due to its antioxidative and anti-in ammatory properties, it is hypothesized to neutralize roundup-induced neurotoxicity.Methods: Thirty-six (36) Wistar rats were used for this study. The animals were shared equally into six groups with six rats each. Glyphosate administration to three of the six groups was done orally and for one week. Either Xylopia aethiopicaor vitamin C was co-administered to two of the three groups and also administered to two other groups and the nal group served as the control.Results: Our studies demonstrated that glyphosate administration led to a signi cant decrease in antioxidants such as catalase, superoxide dismutase, glutathione, and glutathione peroxidase. We also observed a signi cant increase in in ammatory markers such as tumour necrosis factor-α, interleukin 6, C-reactive protein and immunohistochemical expression of caspase-3, cox-2 and p53 proteins (p < 0.05). However, Xylopia aethiopica co-administration with glyphosate was able to ameliorate the aforementioned changes when compared to the control (p < 0.05). Degenerative changes were also observed in the cerebellum, hippocampus, and cerebral cortex upon glyphosate administration. These changes were not observed in the groups treated with Xylopia aethiopica and vitamin C. Conclusion: Taken together, Xylopia aethiopica could possess anti-oxidative and anti-in ammatory properties that could be used in combating glyphosate neurotoxicity.

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Lessons for the clinical nephrologist: acute kidney injury by a glyphosate-surfactant herbicide

et al. 2021

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Determination of acute oral toxicity of glyphosate isopropylamine salt in rats

Cited by 10 publications

References 18 publications

β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation

β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation

Xylopia aethiopica suppresses markers of oxidative stress, inflammation, and cell death in the brain of Wistar rats exposed to glyphosate

Lessons for the clinical nephrologist: acute kidney injury by a glyphosate-surfactant herbicide

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