Determination of aluminium using different techniques based on the Al(III)-morin complex

Domínguez‐Renedo, Olga; Navarro, Ana M.; Ventas-Romay, Eduardo; Alonso‐Lomillo, M. Asunción

doi:10.1016/j.talanta.2018.12.048

Cited by 31 publications

(12 citation statements)

References 47 publications

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“…While a growing body of evidence demonstrates lumogallion as a sensitive and selective fluorescent molecular probe for the visualisation of aluminium in both cells and tissues, morin (2′,3,4′,5,7-pentahydroxyflavone) continues to predominate studies of aluminium distribution in vivo (Eidi et al 2015; Chkheidze et al 2017; Dominguez-Renedo et al 2019). Unlike lumogallion that coordinates 1:1 with aluminium with high selectivity, morin binds to divalent metal cations including calcium and magnesium, yielding a green fluorescence emission (515 nm) upon excitation at 420 nm, as is observed upon its 3:1 coordination to aluminium (Browne et al 1990).…”

Section: Introductionmentioning

confidence: 99%

Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin

Mold

Kumar

Chu

et al. 2019

Histochem Cell Biol

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Aluminium is biologically reactive and its ability to potentiate the immune response has driven its inclusion in both veterinary and human vaccines. Consequently, the need for unequivocal visualisation of aluminium in vivo has created a focused research effort to establish fluorescent molecular probes for this purpose. The most commonly used direct fluorescent labels for the detection of aluminium are morin (2′,3,4′,5,7-pentahydroxyflavone) and lumogallion [4-chloro-3-(2,4-dihydroxyphenylazo)-2-hydroxybenzene-1-sulphonic acid]. While the former has gained popularity in the detection of aluminium in plants and predominantly within root tips, the latter boasts greater sensitivity and selectivity for the detection of aluminium in human cells and tissues. Herein, we have developed a simplified morin staining protocol using the autofluorescence quenching agent, Sudan Black B. This modified protocol improves tissue morphology and increases analytical sensitivity, which allows intracellular aluminium to be detected in monocytes and when co-localised with senile plaques in human brain tissue of donors diagnosed with familial Alzheimer’s disease. Overall, our results demonstrate a simple approach to minimise false positives in the use of morin to unequivocally detect aluminium in vivo.Electronic supplementary materialThe online version of this article (10.1007/s00418-019-01809-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin

Mold

Kumar

Chu

et al. 2019

Histochem Cell Biol

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“…Carbon paste electrodes functionalized with 2.00, 4.00, 5.00, 6.00 and 7.00 % (w/w) complex to graphite were fabricated using TCP as plasticizer. As shown in Table 1, the slopes were found to be 27.93, 26.88, 20.00, 14.66 and 22.50 mV/decade for 2.00, 4.00, 5.00, 6.00 and 7.00 % (w/w), respectively. The electrode with 5.00 % (w/ w) (3) exhibited a good Nernstian slope, Figure 3, and a low detection limit (1.00 × 10 À 6 mol L À 1 ), Table 1.…”

Section: Optimization Of the Electrode's Compositionmentioning

confidence: 84%

“…These methods include indirect electrochemical methods [12], linear scan voltammetry [13], differential pulse voltammetry [14] and square wave voltammogram [15]. However, owing to the extremely negative reduction potential of aluminum, direct electrochemical methods suffer interference from hydrogen ion which make it difficult to detect the aluminum concentration [14,16]. Potentiometric sensors as an inexpensive convenient tool, provide acceptable sensitivity and selectivity for the target metal ion.…”

Section: Introductionmentioning

confidence: 99%

Use of Dicloxacillin Al(III) Complex as a Modifier for Determination of Al(III) Ion in Real Samples

2020

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Three new modified electrodes based on a wellcharacterized Al(III)-Dicloxacillin complex (Dicloxacillin: penicillin antibiotic) in the form of carbon-paste, PVC and coated graphite were fabricated and investigated for determination of Al(III) ions in multivitamin syrup, tap water and soda cans. The developed sensors showed excellent sensitives to Al(III) ions with slopes in the range of 16.77-20.00 mV/concentration decade and detection limits of 4.04 × 10 À 4-3.16 × 10 À 7 mol L À 1 as well as fast response time of 10-20 s. The electrodes were effectively applied as indicators in the potentiometric titration of Al (III) with disodium hydrogen phosphate.

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“…Direct contact with Al is also present during food processing, packaging, and storing (such as kitchen foil, vessels, and various food additives), as well as during dermal applications of personal-care products [2][3][4]. Human exposure to Al is also rising because of acid rains, which cause the partial dissolution of soil aluminum, and because of the presence of Al in tap and drinking waters due to the flocculants used in water treatment plants [5].…”

Section: Introductionmentioning

confidence: 99%

Chemical Speciation of Aluminum in Wine by LC–ICP–MS

2020

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Aluminum is very common in the natural environment and in everyday human life. We are living in the “aluminum age.” Its average daily intake should not exceed a few mg/day. Unfortunately, despite the growing number of alarming data about the toxicity of this element, human exposure to aluminum is constantly increasing. The toxicity and bioavailability of aluminum depends mainly on the form in which it occurs. The main variables conditioning the form are the concentration, the type, the molar ratio of aluminum to ligand, the pH value, and the temperature. This research presents a new method for speciation analysis of both inorganic and organic aluminum complexes in model solutions by LC–ICP–MS. Different solutions with variable pH values and different Al/ligand molar ratios (fluorides and several organic ligands, e.g., citrates and oxalates ions) were used. The chromatographic separation process was carried out based on isocratic and gradient elution, using a cation exchange analytical column. All determinations have been confirmed based on chemical equilibrium modeling programs. The new developed method was successfully applied for the first time in speciation analysis of real samples: white and red wine.

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Determination of aluminium using different techniques based on the Al(III)-morin complex

Cited by 31 publications

References 47 publications

Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin

Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin

Use of Dicloxacillin Al(III) Complex as a Modifier for Determination of Al(III) Ion in Real Samples

Chemical Speciation of Aluminum in Wine by LC–ICP–MS

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