Determination of Aminoglutethimide Enantiomers as Dansyl Derivative in Human Plasma by HPLC with Fluorescence Detection

Aboul‐Enein, H. Y.; Özkırımlı, Sumru; Apak, T. Idil

doi:10.1002/(sici)1521-4184(19994)332:4<145::aid-ardp145>3.0.co;2-4

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…In order to quantitatively determine the presence of AGI, and thus, to control its illegal use, several methods have been described. − The most extended analytical techniques applied for the detection of this drug are liquid chromatography–mass spectrometry (LC-MS) and capillary electrophoresis (CE). However, LC-MS requires analyte preconcentration for detecting low concentrations, and CE does not afford any molecular information about the structure of the studied compound, apart from the usual need of preconcentration.…”

Section: Introductionmentioning

confidence: 99%

Adsorption and Detection of Sport Doping Drugs on Metallic Plasmonic Nanoparticles of Different Morphology

et al. 2012

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A comparative study of different plasmonic nanoparticles with different morphologies (nanospheres and triangular nanoprisms) and metals (Ag and Au) was done in this work and applied to the ultrasensitive detection of aminoglutethimide (AGI) drug by surface enhanced Raman spectroscopy (SERS) and plasmon resonance. AGI is an aromatase inhibitor used as an antitumoral drug with remarkable pharmacological interest and also in illegal sport doping. The application of very sensitive spectroscopic techniques based on the localization of an electromagnetic field on plasmonic nanoparticles confirms the previous study of the adsorption of drugs onto a metal surface due to the near field character of these techniques. The adsorption of AGI on the above substrates was investigated at different pH values and surface coverages, and the results were analyzed on the basis of AGI/metal affinity, considering the interaction mechanism, the existence of two binding sites in AGI, and the influence of the interface on the adsorption in terms of surface charge due to the presence of other ions linked to the surface. Finally, a comparative quantitative detection of AGI was performed on both spherical and triangular nanoprism nanoparticles, and a limit of detection lower than those reported so far was deduced on the latter nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Adsorption and Detection of Sport Doping Drugs on Metallic Plasmonic Nanoparticles of Different Morphology

et al. 2012

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“…[4][5][6][7][8][9][10][11][12][13][14] Thin-layer chromatography (TLC) has advantages relative to other analytical techniques, such as low cost and simplicity of the method. Resolution of the racemic aminoglutethimide by high performance liquid chromatography has been reported in earlier works.…”

Section: Introductionmentioning

confidence: 99%

ENANTIOMERIC SEPARATION OF AMINOGLUTETHIMIDE, ACETYL AMINOGLUTETHIMIDE, AND DANSYL AMINOGLUTETHIMIDE BY TLC WITH Β-Cyclodextrin AND DERIVATIVES AS MOBILE PHASE ADDITIVES

Aboul‐Enein

El-Awady

Heard

2000

Journal of Liquid Chromatography & Related Technologies

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Racemic aminoglutethimide and acetylaminoglutethimide were resolved on a fluorescent Silica gel 60A TLC plate using 30% hydroxy trimethylpropylammonium-β-cyclodextrin with methanol (50:50v/v) as the mobile phase. Also, the resolution of the enantiomers of aminoglutethimide as dansyl derivatives were investigated on reversed phase TLC using a mobile phase consist-2715 Downloaded by [University of Otago] at 08:24 02 October 2015ing of a β-cyclodextrin solution (0.05 M saturated with urea), or 15% (carboxymethyl-β-cyclodextrin) solution with methanol (65:35v/v). Enantiomeric resolution was found to be highly dependent on mobile phase composition. The effect of the type and amount of organic modifier as well as the concentration of β-CD derivative, and the pH of the mobile phase on resolution were studied. Three types of maltodextrins failed to show resolution for any of the racemic compounds studied.

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Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide

Kadhirvel

Azenha

Schillinger

et al. 2014

Journal of Chromatography A

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Determination of Aminoglutethimide Enantiomers as Dansyl Derivative in Human Plasma by HPLC with Fluorescence Detection

Cited by 4 publications

References 13 publications

Adsorption and Detection of Sport Doping Drugs on Metallic Plasmonic Nanoparticles of Different Morphology

Adsorption and Detection of Sport Doping Drugs on Metallic Plasmonic Nanoparticles of Different Morphology

ENANTIOMERIC SEPARATION OF AMINOGLUTETHIMIDE, ACETYL AMINOGLUTETHIMIDE, AND DANSYL AMINOGLUTETHIMIDE BY TLC WITH Β-Cyclodextrin AND DERIVATIVES AS MOBILE PHASE ADDITIVES

Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide

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