Determination of Anti Colon Cancer Drug, Irinotecan by Fast Fourier Transforms Continuous Cyclic Voltammetry

Norouzi, Parviz; Qomi, Mahnaz; Nemati, Ali

doi:10.1016/s1452-3981(23)15219-9

Cited by 38 publications

(1 citation statement)

References 36 publications

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“…For irinotecan (topoisomerase 1 inhibitor), the most significant results were achieved on Au microelectrode by fast Fourier transform continuous CV with accumulation step. [203] Although interesting, missing selectivity studies must be completed to evaluate the proposed protocol utility.…”

Section: Plant Alkaloids and Other Natural Productsmentioning

confidence: 99%

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

Brycht

Półtorak

Baluchová

et al. 2022

Critical Reviews in Analytical Chemistry

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Cancer is most frequently treated with antineoplastic agents (ANAs) that are hazardous to patients undergoing chemotherapy and the healthcare workers who handle ANAs in the course of their duties. All aspects related to hazardous oncological drugs illustrate that the monitoring of ANAs is essential to minimize the risks associated with these drugs. Among all analytical techniques used to test ANAs, electrochemistry holds an important position. This review, for the first time, comprehensively describes the progress done in electrochemistry of ANAs by means of a variety of bare or modified (bio)sensors over the last four decades (in the period of 1982-2021). Attention is paid not only to the development of electrochemical sensing protocols of ANAs in various biological, environmental, and pharmaceutical matrices but also to achievements of electrochemical techniques in the examination of the interactions of ANAs with deoxyribonucleic acid (DNA), carcinogenic cells, biomimetic membranes, peptides, and enzymes. Other aspects, including the enantiopurity studies, differentiation between single-stranded and double-stranded DNA without using any label or tag, studies on ANAs degradation, and their pharmacokinetics, by means of electrochemical techniques are also commented. Finally, concluding remarks that underline the existence of a significant niche for the basic electrochemical research that should be filled in the future are presented.

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Section: Plant Alkaloids and Other Natural Productsmentioning

confidence: 99%

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

Brycht

Półtorak

Baluchová

et al. 2022

Critical Reviews in Analytical Chemistry

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Square Wave Cathodic Adsorptive Stripping Voltammetric Determination of the Anticancer Drugs Flutamide and Irinotecan in Biological Fluids Using Renewable Pencil Graphite Electrodes

2015

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1IntroductionThea ntitumoral activity of flutamide {2-methyl-N-[4-nitro-3-(trifluoro methyl) phenyl] propanamide}( Flu) and irinotecan {7-ethyl-10-[4-(1-piperidino)1-piperidino] carbonyloxy-camptothecin} (Irino)( Scheme 1) against certain types of cancers was previously reported.Flutamide seems to have antiandrogenics pecificity only in androgend ependentg enitalia organs,a nd its therapeuticu se is in prostatic cancer [1][2][3][4].A sf lutamide has as tructure similar to testosterone,i tw orksb ya ttaching itself to the receptors on the surface of the cancer cells to block and prevent the attachment of the male hormone [5].I rinotecan is one of the key drugs of anticancer chemotherapy,e specially for the treatment of colorectal and lung tumors as well as other types of cancers [6,7].T he large scale therapeutic use of Flu and Irino generated the need for the development of fast, simple accuratem ethodologies for detection and quality control for both drugs in biological fluids. In this context methods reporting the determinationo fFlu and Irino include chromatography ,s pectrophotometry [31-35],s pectrofluorimetry [36] and few electrochemical methods [37][38][39][40][41][42][43].P olarographicr eduction of Flu was performed at ad ropping mercurye lectrode usingd irect currentp olarographya nd differential pulse polarography [37,38,40].L inear sweep and square waveforms were optimized for the determination of Flu based on the reduction of its nitro aromatic moiety at the hanging mercury drop electrode [39].D etermination of Flu ins urfactant containingm edia at polymer filmm odified carbon paste electrodes usingd ifferential pulsev oltammetryw as reported [41].E lectroanalytical determination of Irino was achieved using fast Fourier transform continuous cyclic voltammetry at gold microelectrodes in aflow system [42].V oltammetric determination of Irino at polymethylene blue multiwalled carbon nanotubes modified glassy carbone lectrode was reported as well [43].T ot he best of our knowledge,t he controlled adsorptive accumulationo fF lu or Irino on the surface of pencil graphite electrodes (PGE) for square wave cathodic adsorptive stripping determinationw as not reported yet. In view of the biological importance of Flu and Irino, this work aims on the development of as imple and sensiAbstract:Asensitive electrochemical method based on square wave cathodic adsorptive strippingv oltammetry (SWCASV) using pencil graphite electrodes( PGE)w as developed for the individual and simultaneous determination of the anticancer drugs flutamide( Flu)a nd irinotecan (Irino) in biological fluids.C alibration curves showed an excellent linear response with limitso fd etection of 1.68 10 À9 and 1.55 10 À8 MI rino and Flu,r espectively. Thes tatistical evaluation of within-day repeatability (n = 5) and day to day precision (n = 5) showed satisfactory accuracy and precision. SWCASV using aPGE for individual and simultaneous determination of both drugs in bulk form, human urine and serums amples was demonstrated.

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Voltammetric Characterisation of Anticancer Drug Irinotecan

et al. 2017

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Electrochemical reduction of irinotecan was investigated on a static mercury drop electrode using square‐wave voltammetry. The mechanism of irinotecan electroreduction is a complex, pH‐dependent, quasireversible process and includes the transfer of two electrons and two protons. In acidic medium, the first electron transfer reaction is followed by the chemical reaction, and the product of this chemical reaction undergoes further electrochemical reduction at more negative potentials. Both irinotecan and the product of its reduction adsorb on the mercury electrode surface. Based on the adsorptive character of irinotecan, a new adsorptive stripping square‐wave voltammetric method for its electroanalytical determination has been proposed. The voltammetric response could be used to determine irinotecan in the concentration range from 1×10−7 mol/L to 1.5×10−6 mol/L and from 5×10−9 mol/L to 1.2×10−7 mol/L, if the accumulation time is 20 s and 300 s, respectively. The calculated limit of detection for irinotecan was found to be 8.7×10−9 mol/L (if tacc=300 s).

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Determination of Anti Colon Cancer Drug, Irinotecan by Fast Fourier Transforms Continuous Cyclic Voltammetry

Cited by 38 publications

References 36 publications

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

Square Wave Cathodic Adsorptive Stripping Voltammetric Determination of the Anticancer Drugs Flutamide and Irinotecan in Biological Fluids Using Renewable Pencil Graphite Electrodes

Voltammetric Characterisation of Anticancer Drug Irinotecan

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