Determination of Atenolol in Tablet Formulation by Analytical Spectrophotometry

Antakli, Saad; Nejem, Leon; Joumaa, Moustafa Alabo

doi:10.5958/0974-360x.2020.00115.8

Cited by 6 publications

(2 citation statements)

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“…These include voltammetry methods for ATE analysis in pharmaceutical products (Moraes et al, 2016) and urine (Afonso et al, 2016), GC-MS method for the analysis of ATE and bisoprolol in human bone (Fernandez-Lopez et al, 2019), and UPLC-MS for the analysis of ATE and chlorthalidone in human plasma (Shah et al, 2016). Also, different mixtures containing ATE were analyzed using HPLC methods (Anderson et al, 2017;El-Alfy et al, 2019;Elkady et al, 2020;Kannappan & Mannemala, 2016) in addition to spectrophotometry (Antakli et al, 2020;Mohammad et al, 2019;Saleem, 2019;Vaikosen et al, 2020) and capillary electrophoresis (Kuraeva et al, 2016). Tabrizi et al (Tabrizi & Yousefzadeh, 2019) developed a spectrofluorimetric method for the determination of ATE and carvedilol in pharmaceutical preparations, while Damiani et al developed a spectrofluorimetric method for the determination of ATE in human urine by emissionexcitation fluorescence matrices (Damiani, 2011).…”

Section: Introductionmentioning

confidence: 99%

Green spectrofluorimetric method for determination of atenolol in pharmaceutical tablets and human urine

El-waey,

Abdel Salam,

Hadad

et al. 2024

Records of Pharmaceutical and Biomedical Sciences

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An environment-friendly, sensitive, simple, and economic spectrofluorimetric method for the analysis of atenolol in pure powder, pharmaceutical preparations, and urine using green solvents was developed. The analysis was carried out using the solvent 0.02 N NaOH to reach the concentration range of 30-800 ng/ml, and fluorescence intensities were measured at 301±1nm after excitation at 255 nm using a slit width of 5 nm. The effects of different solvents, different pHs, and different concentrations of NaOH were studied. The method was applied successfully to pharmaceutical tablets and spiked urine samples. The proposed method was applied to investigate the urinary excretion pattern of atenolol in a healthy male volunteer after oral administration of a 50 mg single dose. Urine samples were collected at intervals for up to 24 hours. The method was validated according to the ICH guidelines, proving that it is accurate, specific, precise, and robust. So, it is suitable for quality control analysis of atenolol and for the detection of drug abuse in precision sports due to its sensitivity for the determination of atenolol on a regular basis at therapeutic urine levels. The method complies with the principles of green analytical chemistry due to its short analysis time, high sensitivity, low cost, simple instruments, small energy consumption, very little waste, and being free from harmful solvents, ensuring operator safety. The proposed method's high level of greenness was proved by its high eco-scale score (95 points) as well as by the GAPI and AGREE greenness assessments.

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Section: Introductionmentioning

confidence: 99%

Green spectrofluorimetric method for determination of atenolol in pharmaceutical tablets and human urine

El-waey,

Abdel Salam,

Hadad

et al. 2024

Records of Pharmaceutical and Biomedical Sciences

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“…In literature research, UV-Visible spectrophotometry (Saleem, 2019;Antakli et al, 2020;Mohammad et al, 2019;Vaikosen et al, 2020), spectrofluorometry (Tabrizi and Yousefzadeh, 2019), high-performance liquid chromatography (HPLC) (Pires de Abreu et al, 2003;Iha et al,. 2002;Chiu et al, 1997;Madhusudhan et al, 2018;El-Alfy et al, 2019;Elkady et al, 2020), gas chromatography-mass spectrometry (GC-MS) (Yilmaz et al, 2009) and capillary electrophoresis (Arias et al, 2001) methods for determining atenolol in invitro conditions and biological materials have been reached.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Atenolol in Rabbit Plasma by HPLC Method

Yılmaz

2023

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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The goal of this research is to develop a high-performance liquid chromatography method for analyzing atenolol levels in rabbit plasma and apply this method to the pharmacokinetic study. The liquid-liquid extraction technique was used to prepare blood samples from rabbits. Separation of atenolol was achieved on an Ace C18 column. The method’s calibration curve was plotted between 5 and 250 ng/mL. The accuracy results were better than 2.97% and the precision results were less than 6.30% in rabbit plasma for atenolol. The method had recovery values >95.8% for all samples in rabbit plasma. In addition, the validated method was used to study atenolol pharmacokinetics in rabbits. The maximum atenolol plasma concentration is 240.1 ± 33.41 ng/mL. The duration to attain the greatest atenolol concentration and the area under the curve from (AUC0-12 h) were 3.0 ± 0.64 h and 1184.1 ± 235.13 ng/mL h, respectively.

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