Determination of bisphenol-a and related compounds in human saliva by gas chromatography—mass spectrometry

Bisphenol A (BPA) daily intakes in the United States: Estimates from the 2003–2004 NHANES urinary BPA data

“…To achieve enhanced sensitivity and selectivity, the phenols have been derivatized to alkyl or acyl derivatives before GC-mass spectrometry (GC/MS) analysis. [23][24][25][26][27][28][29][30][31] We have developed a sensitive method for measuring BPA, 4-tert-octylphenol (tOP), benzophenone-3 (BP-3), and five chlorophenols [2,4-dichlorophenol(24-DCP), 2,5-dichlorophenol (25-DCP), 2,45,-trichlorophenol (245-TCP), 2,4,6-trichlorophenol (246-TCP) and triclosan]. The method uses solid phase extraction (SPE) coupled on-line to HPLC and tandem mass spectrometry (MS/MS).…”

Application of solid phase microextraction on dental composite resin analysis

“…Especially it is difficult to work on the small amount of sample using these conventional sample treatment techniques while the large volume of saliva sample is not practically collected. Zafra et al [12] proposed a GC-MS method for detection and determination of bisphenol-A, Bis-GMA, Bis-DMA and TEGDMA in human saliva. Their method showed a detection limit as low as 0.3-10 g/L for the analytes.…”

“…Direct SPME is often employed for the assay of drugs and related analytes in plasma and urine [13]. Monomers of dental resins, such as TEGDMA (MW 286), UDMA (MW 470) and Bis-GMA (MW 512), have a high molecular weight, and only decomposed products are detectable in the gas chromatography [12]. Therefore, high performance liquid chromatography (HPLC) is a practical method for the measurement of co-monomers with a large molecular weight [14].…”

Development and Validation of an Isocratic HPLC Method for the Simultaneous Determination of Residual Monomers Released From Dental Polymeric Materials in Artificial Saliva

“…The identification of the released components is usually performed by utilizing liquid chromatography=mass spectrometry and gas chromatography. [12][13][14][15][16][17][18][19] Yet, it is necessary to note that monomers of high molecular weight such as BIS-GMA (MW ¼ 512) and UDMA (MW ¼ 470) decompose during processing in a gas chromatograph; therefore, only their decomposition products can be detected. Volatile materials have been analyzed by gas chromatography=mass spectrometry (GC=MS), while less volatile materials have been separated by liquid chromatography (LC).…”