Since 2020, the rapid global spread of the COVID-19 pandemic has generated unprecedented impacts on the management of hospital buildings, namely: (i) providing space for patients, medical staff, and equipment storage, (ii) imposition of limitations on access by the teams responsible for managing the building, (iii) adapting the space and its functionality quickly, (iv) ensuring continuous control of air quality and adequate ventilation of spaces, (v) development of digital tools for management, and (vi) assets monitoring in real-time. In addition, hospital buildings facilities’ deterioration rate is typically higher than in other buildings, enhanced by the fact that these facilities are open 24 hours a day, year-round. Thus, facilities management (FM) assumes a vital role in the future of healthcare facilities. FM is expected to grow at a 5% annual rate for 2021-2028, representing an acceleration of the industry at a global level. Furthermore, Industry 4.0 may positively impact the FM processes. As a new industrial revolution, providing a set of new approaches and tools will increase the efficiency of operations, significantly impacting the potential of optimization. These trends can improve planning and management of scope, costs, environment, and safety in the value chain of projects and assets, thus creating a more resilient and sustainable industry. Based on a literature review, this paper contributes to the discussion of the questions: How can the digital transition improve the management of the operation and maintenance of infrastructure in healthcare facilities? What is the legacy for FM teams in this post-COVID-19 management of hospital buildings?