Determination of C-reactive protein in the blood as a measure of the activity of the disease process in acute rheumatic fever

Levels of C-reactive protein in serum samples from healthy children and adults in São Paulo, Brazil

“…Increased levels of serum CRP have been found in virtually all diseases associated with active inflammation or tissue destruction, such as rheumatoid diseases, acute infectious processes, postmyocardial infarction or surgery, advanced and widespread malignancy, and chronic infections (10,18,31). Thus, elevated CRP levels serve as a nonspecific indicator for the presence of one of these processes, rather than as an indicator of a specific pathology.…”

“…Thus, elevated CRP levels serve as a nonspecific indicator for the presence of one of these processes, rather than as an indicator of a specific pathology. CRP levels have been used clinically to gauge the presence and extent of inflammation, as well as to evaluate the effectiveness of anti-inflammatory therapy, mainly in rheumatoid diseases (18). The major finding in this area was the strong association between marked increases in serum CRP concentrations (over 100 mg/l) and severe bacterial infections (32).…”

The Values of Some Plasma Components During the Early Phases of Fracture Healing in Man

“…Plasma hydroxyproline increases, but less noticeably than in similar experimental studies (Lyritis et al 1975). A change of C-reactive protein to positive is considered to be a reaction of the body to the inflammation occurring at the fracture site (Anderson & McCarty 1950).…”

Observations on the course and treatment of systemic lupus erythematosus

“…Some patients had been treated previously at other institutions, hut all were under oiir observation for the major part of their clinical course, which ranged from sevcral months to five years. There were 20 females and four males; the agc at onset ranged between 13 and 61 (table 1); 15 of the patients were white, eight negro, and one Chinese.…”