Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil

Böger, Beatriz; Amaral, Bianca do; Estevão, Priscila Lagner da Silveira; Wagner, Ricardo; Peralta‐Zamora, Patricio; Gomes, Eliane Carneiro

doi:10.4136/ambi-agua.2196

Cited by 11 publications

(5 citation statements)

References 20 publications

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“…Stock solutions of diazepam or duloxetine were prepared by dissolving diazepam in DMF. On the basis of the environmental concentration (diazepam, 0.763 µg/L; duloxetine, 0.08 µg/L in the effluent; Böger et al, 2018; Osawa et al, 2019), we set up five test concentrations for each exposure test (diazepam: solvent control, 0.8, 4, 20, and 100 µg/L; duloxetine: solvent control, 0.1, 0.5, 2.5, and 12.5 µg/L). One milliliter of a stock solution was added to 18 L of dechlorinated water and mixed well using a glass rod to achieve the test concentrations.…”

Section: Methodsmentioning

confidence: 99%

Peek-A-Boo Test: A Simple Test for Assessing the Effect of Anxiolytics on Fish Behavior

Takai¹,

Izumi²,

Motoyama³

et al. 2023

Environmental Toxicology and Chemistry

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The potential of pharmaceuticals and personal‐care products to alter the behavior of aquatic organisms is a growing concern. To assess the actual effect of these substances on aquatic organisms, a simple but effective behavioral test is required. In this study, we devised a simple behavioral test (peek‐a‐boo test) to assess the effect of anxiolytics on the behavior of a model fish (medaka, Oryzias latipes). In the peek‐a‐boo test, we investigated the response of medaka to an image of a predator fish (donko fish, Odontobutis obscura). The test revealed that the time taken for test medaka exposed to diazepam (0.8, 4, 20, or 100 µg/L) to approach the image was shorter by a factor of 0.22–0.65 and the time spent in the area close to the image was longer by a factor of 1.8–2.7 than in the solvent control group for all diazepam exposure groups (P < 0.05). Hence, we confirmed that the peek‐a‐boo test could detect changes in medaka behavior caused by diazepam with high sensitivity. The peek‐a‐boo test devised in this study is a simple behavioral test with high sensitivity for fish behavioral alteration.

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Section: Methodsmentioning

confidence: 99%

Peek-A-Boo Test: A Simple Test for Assessing the Effect of Anxiolytics on Fish Behavior

Takai¹,

Izumi²,

Motoyama³

et al. 2023

Environmental Toxicology and Chemistry

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“…First, to represent “expert choice” and include an element of (perceived) risk to the environment, the literature was reviewed to determine which pharmaceutical micropollutants had been monitored in the rivers of the Metropolitan Region of Curitiba and to identify the minimum and maximum concentrations for these compounds. It was established that only 27 compounds from 9 different classes (hormones, antihypertensives, anti inflammatories, analgesics, psychotropics, metabolites, lipid regulators, stimulants, and food and cosmetic preservatives) (Ide et al 2013; Kramer et al 2015; Osawa et al 2015; Böger et al 2018; Barcellos et al 2019a) had been monitored in this region. Several shortcomings to this first approach are acknowledged.…”

Section: Methodsmentioning

confidence: 99%

Priority Pharmaceutical Micropollutants and Feasible Management Initiatives to Control Water Pollution from the Perspective of Stakeholders in Metropolis of Southern Brazil

Barcellos

Helwig

Gervasoni³

et al. 2020

Integr Envir Assess & Manag

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The search for common agreement between stakeholders is one of the biggest challenges when solving environmental problems. There are different views, perceptions, knowledge, and sectoral goals for these stakeholders. In complex environmental problems, such as the management of pharmaceutical micropollutants, it is essential to establish the intersectoral and individual sector priorities for a collective approach to the problem. This research aimed to identify the priority micropollutants for intervention initiatives and the management goals of the stakeholders involved in the "product chain" of pharmaceuticals in the region of Curitiba, Brazil. First, the most consumed pharmaceutical micropollutants in the region and those previously detected in water were identified, and a "long list" of 40 pharmaceuticals was drawn up for stakeholder prioritization. Stakeholders of the region were selected by intentional sampling and were invited to a workshop that was designed to list, by consensus, the priority micropollutants and objectives for their management. The event was attended by 37 stakeholders from different sectors. It was divided into 2 stages: the 1 st stage was a multisectoral discussion to select the priority pharmaceutical micropollutants; the 2 nd stage was a sectoral discussion to establish management objectives to control and reduce the presence of these pollutants in waters. The meeting generated a coherent prioritization of pharmaceuticals where ethinyl estradiol, ciprofloxacin, ibuprofen, diclofenac, estradiol, caffeine, and fluoxetine were prioritized and their importance was justified. The main sectoral goals prioritized were related to the drug take-back program, the characterization of the presence of pharmaceuticals in the sanitation cycle, and the creation of a permanent multisector discussion environment for the theme. The multisectoral definition, established by consensus, of management priorities is promising and this strategic approach can be replicated in other developing countries. Integr Environ Assess Manag 2020;16: 955-967.

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“…The percentage recoveries in this study are detailed Table S3 as calculated using standard approach from literature (Wardenier, 2016). Literature shows the acceptable range for the recovery of CBZ in the water at 80%-120% (Böger et al, 2018;Krause et al, 2011;Miao & Metcalfe, 2003).…”

Section: Sample Preparation and Analysismentioning

confidence: 99%

Removal efficiency and energy consumption optimization for carbamazepine degradation in wastewater by electrohydraulic discharge

Gwanzura

Ramjugernath

Iwarere

2023

Water Environment Research

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OBJECTIVEThe treatment of recalcitrant emerging pollutants is a major concern in wastewater treatment. The purpose of this study was the optimisation of emerging recalcitrant pollutant degradation using carbamazepine as a representative pollutant. Investigations of the carbamazepine degradation in wastewater was carried out by manipulating discharge current, air flow rate, and initial concentration to maximise removal efficiency and minimise energy consumption.METHODThe study utilised a three factor at two levels factorial design with randomised central runs. Discharge current, air flow rate, and initial concentration were the independent variables while to removal efficiency and minimise energy consumption were the response variables. ANOVA analysis was performed on the data.RESULTSDischarge current, air flow rate, and initial concentration significantly impacted the removal efficiency to different degrees. However, for energy consumption, only current and air flow rate were the significant variables. The highest removal efficiency obtained was 93% ± 4% for 10 and 40 mg/L initial carbamazepine concentration after 10 minutes of plasma treatment at a current of 0.45 A and no air flow rate.CONCLUSIONThe reactor demonstrated the capability to treat high cyclic organic chemical contaminant concentration in wastewater with possible applications in pre‐concentrated wastewater remediation. However, there is still room for reactor design optimisation. One key area of focus is reducing treatment cost, which may be achieved theoretically, pending further experimental investigation, by introducing an alternating current power supply which can reduce energy consumption by 50‐60%.

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Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil

Cited by 11 publications

References 20 publications

Peek-A-Boo Test: A Simple Test for Assessing the Effect of Anxiolytics on Fish Behavior

Peek-A-Boo Test: A Simple Test for Assessing the Effect of Anxiolytics on Fish Behavior

Priority Pharmaceutical Micropollutants and Feasible Management Initiatives to Control Water Pollution from the Perspective of Stakeholders in Metropolis of Southern Brazil

Removal efficiency and energy consumption optimization for carbamazepine degradation in wastewater by electrohydraulic discharge

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