Determination of Chemical Composition and Investigation of Biological Activities of Ocimum basilicum L.

Qasem, Ahmed; Assaggaf, Hamza; Mrabti, Hanae Naceiri; Minshawi, Faisal; Rajab, Bodour S.; Attar, Ammar A.; Alyamani, Reema A.; Hamed, Munerah; Mrabti, Nidal Naceiri; Baaboua, Aicha El; Omari, Nasreddine El; Alshahrani, Mohammed; Awadh, Ahmed Abdullah Al; Sheikh, Ryan A.; Ming, Long Chiau; Goh, Khang Wen; Bouyahya, Abdelhakim

doi:10.3390/molecules28020614

Cited by 13 publications

(2 citation statements)

References 103 publications

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“…It may be found in various living things, from plants and animals to bacteria and other bacterium-like organisms. Complex carbohydrates have the potential to be more challenging to digest if human a-amylase synthesis is slowed down or stopped altogether 5,6 .…”

Section: Fig 1: the Buncis Or Chickpea Plant And Its Fruitmentioning

confidence: 99%

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2023

IJPSR

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Chickpeas (Phaseolus vulgaris L.) contain various healthpromoting bioactive components. Examples: Alkaloids, anthocyanins, catechins, carbohydrates, fibre, flavonoids, phytic acid, quercetin, saponins, steroids, tannins and terpenoids are plant components. Nevertheless, little is known about how these bioactive chemicals function in progressive situations. These results suggest that P. vulgaris seeds could cure metabolic diseases, including diabetes and obesity. This research offers enormous potential for nutraceuticals. Further research is needed to confirm and extend previous findings. Phaseolus vulgaris seeds are also needed in complementary and alternative medicine and pharmaceutical companies. Plant-derived drugs like quinine, artemisinin, digoxin, atropine, strychnine and reserpine have been demonstrated to treat many disorders. Due to their low cost, effectiveness, and safety, traditional medicine and herbal medicines provide the most primary medical care in the world's poorest countries. Any plant component can produce secondary metabolites or bioactive compounds. Glycosides, tannins, alkaloids, flavonoids, steroids, and triterpenoids have several health benefits. After testing, these plant chemicals are antibacterial, antioxidant, anticancer, and antidiabetic. INTRODUCTION:Chickpeas are pods harvested from the Phaseolus vulgaris plant and then consumed by humans. They are also known as "Buncis" (derived from the Dutch term for legumes, "boontjes"). Vegetables may be anything that humans, including fruit, seeds, and leaves ingest. This vegetable truly excels when it comes to the amount of protein that it contains. Most people believe he was born in either South or Central America.

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Section: Fig 1: the Buncis Or Chickpea Plant And Its Fruitmentioning

confidence: 99%

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2023

IJPSR

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“…Not only does basil have traditional uses, but it also has super-effective anti-kidney disorders, colds, and diarrhea due to its richness in bioactive compounds, in addition to protecting against cardiovascular diseases and nerve pains [6]. As well as, researchersproved the biological activities of basil essential oil and aqueous extracts as antidiabetic and dermatoprotective effects [7].…”

Section: Introductionmentioning

confidence: 99%

Enhancing french basil growth through synergistic Foliar treatment with copper nanoparticles and Spirulina sp.

Elbanna,

Ahmed,

Fayed

et al. 2024

BMC Plant Biol

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Background This study investigates a novel idea about the foliar application of nanoparticles as nanofertilizer combined with a natural stimulant, blue-green algae Spirulina platensis L. extract, as a bio-fertilizer to achieve safety from using nanoparticles for enhancement of the growth and production of the plant. Thus, this experiment aimed to chemically synthesize copper nanoparticles via copper sulfate in addition to evaluate the impact of CuNPs at 500, 1000, and 1500 mg/L and the combination of CuNPs with or without microalgae extract at 0.5, 1, and 1.5 g/L on the morphological parameters, photosynthetic pigments accumulation, essential oil production, and antioxidant activity of French basil. Results The results revealed that foliar application of CuNPs and its interaction with spirulina extract significantly increased growth and yield compared with control, the treatments of 1000 and 1500 mg/L had less impact than 500 mg/L CuNPs. Plants treated with 500 mg/L CuNPs and 1.5 g/L spirulina extract showed the best growth and oil production, as well as the highest accumulation of chlorophylls and carotenoids. The application of CuNPs nanofertilizer caused a significant increase in the antioxidant activity of the French basil plant, but the combination of CuNPs with spirulina extract caused a decrease in antioxidant activity. Conculosion Therefore, foliar application of natural bio-fertilizer with CuNPsis necessary for obtaining the best growth and highest oil production from the French basil plant with the least damage to the plant and the environment.

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Exploring of Chemical Profile and Biological Activities of Three Ocimum Species From Comoros Islands: A Combination of In Vitro and In Silico Insights

Cetiz,

Isah,

et al. 2024

Cell Biochemistry & Function

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Ocimum species have a great interest in different traditional medicinal systems. This study examined the chemical composition, antioxidant properties, enzyme inhibitory effects, and antibacterial and antifungal activities of the aerial parts of Ocimum gratissimum, Ocimum americanum, and Ocimum basilicum from the Comoros Islands. The extracts were analyzed using high‐performance liquid chromatography‐mass spectrometry (HPLC‐MS) to determine their chemical composition. Antioxidant activity was assessed using 2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH), 2,2′‐Azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) diammonium salt (ABTS), cupric reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), chelating ability, and phosphomolybdenum radical scavenging assays. Enzyme inhibitory activities against acetylcholinesterase (AChE), butrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase were evaluated using spectrophotometric methods. Antibacterial and antifungal activities were tested using the broth microdilution method against selected pathogenic microorganisms. The selected enzymes and proteins were evaluated using in silico methods with biomolecules from these plants. In addition, 111 different metabolites were identified in the tested extracts using advanced HPLC/MS techniques. The most significant number of detected compounds were derivatives of hydroxycinnamic acids, followed by flavonoid glycosides and aglycones and derivatives of hydroxybenzoic acids. All three Ocimum species exhibited significant antioxidant activities, O. gratissimum exhibited the best‐reducing abilities in CUPRAC and FRAP assays. In addition, enzyme inhibitory assays revealed that O. americanum had the most potent inhibitory effect on tyrosinase (48.01 ± 3.89 mg kojic acid equivalent [KAE]/g), and amylase (1.08 ± 0.02 mmol acarbose equivalent [ACAE]/g). Antibacterial and antifungal tests demonstrated that the extracts possess broad‐spectrum activity. Molecular docking results showed that compounds exhibited remarkable binding energies with target enzymes and proteins. The molecular dynamics simulations identified chicoric acid with MurE of Staphylococcus aureus complex as the most promising drug candidate. These findings support their traditional medical and nutraceutical uses and suggest possibilities for natural functional applications.

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Determination of Chemical Composition and Investigation of Biological Activities of Ocimum basilicum L.

Cited by 13 publications

References 103 publications

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Enhancing french basil growth through synergistic Foliar treatment with copper nanoparticles and Spirulina sp.

Exploring of Chemical Profile and Biological Activities of Three Ocimum Species From Comoros Islands: A Combination of In Vitro and In Silico Insights

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