Determination of chloramphenicol in meat samples using liquid chromatography–tandem mass spectrometry

Abstract

Chloramphenicol (CAP; C 11 H 12 Cl 2 N 2 O 5 ; Figure 1) is a broadspectrum antibiotic having activity against both gram-positive and gram-negative bacteria and is effective in the treatment of several infectious diseases in animals all over the world, including food-producing animals because of low cost, great pharmacokinetics properties (Zhiming et al., 2015), remarkable penetration into the tissues, and ready availability (Rønning et al., 2006). However, CAP is, in certain susceptible individuals, associated with harmful

Nanomaterials Based on 2,7,12,17-Tetra-tert-butyl-5,10,15,20-tetraaza-21H,23H-porphine Exhibiting Bifunctional Sensitivity for Monitoring Chloramphenicol and Co2+

“…The linear dependence between the intensity of the absorption of the AuNPs-TBAP complex read at 637 nm and the CHL concentration in the range between 3.58 × 10 −6 M and 3.37 × 10 −5 M is characterized by a very good coefficient of correlation (99.44%), as presented in Figure 13. As can be concluded from the two experiments, the first one using the solely acidified TBAP-azaporphyrin and the second one being based on the same porphyrin synergistically complexed with AuNPs, these two methods are complementary, extending the detection of chloramphenicol from 3.58 × 10 −6 M to 3.37 × 10 −5 M, a domain that represents the relevant field for detecting the CHL levels in the human body fluids [65,66] and food [67][68][69], and in the industries where one must monitor for environmental control [70].…”

“…cally complexed with AuNPs, these two methods are complementary, extending the de-tection of chloramphenicol from 3.58 × 10 −6 M to 3.37 × 10 −5 M, a domain that represents the relevant field for detecting the CHL levels in the human body fluids [65,66] and food [67][68][69], and in the industries where one must monitor for environmental control [70].…”

MXene–AuNP-Based Electrochemical Aptasensor for Ultra-Sensitive Detection of Chloramphenicol in Honey

“…So far, several techniques for detecting CAP drug residue have been developed, for example, photoinduced chemiluminescence, high-performance liquid chromatography (HPLC) [ 7 ], liquid chromatography (LC) [ 8 ], liquid chromatography–mass spectrometry (LC-MS) [ 9 ], and gas chromatography–mass spectrometry (GC-MS) [ 10 ] etc. Although these methods are reliable, they are accompanied by the disadvantages of cumbersome instrumentation, complicated operation, and high cost.…”

Ultra-sensitive detection of florfenicol by flow injection chemiluminescence immunoassay based on Nickel/Cobalt bimetallic metal–organic framework nanozymes

“…24 Simultaneously, when people ingest animal-derived foods with excessive FF residues, it will pose a certain risk to human health. So far, the detection of FF has mainly focused on chromatography, such as liquid chromatography-mass spectrometry (LC-MS), 25 ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), 26 ultra-performance liquid chromatography-electrospray ionization tandem triple quadrupole mass spectrometry (UPLC-ESI/MS/MS), 27 gas chromatography-electron ionization tandem mass spectrometry (GC-EI/MS/MS), 28 etc . Although these methods are simple to operate and fast to detect, they require high technical requirements, expensive equipment, and low selectivity and sensitivity.…”