Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis

Vetchý, David; Landová, Hana; Gajdziok, Jan; Doležel, Petr; Daněk, Zdeněk; Štembírek, Jan

doi:10.1016/j.ejpb.2013.12.002

Cited by 28 publications

(23 citation statements)

References 27 publications

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“…The relevant disadvantage is the requirement of thermal stability in all materials, moisture free components, limited and expensive excipients, and the requirement of specialized equipment [10]. Alternative methods for manufacturing MOFs consist of compressing or freeze-drying polymer powders and mixtures or printing active pharmaceutical ingredients onto a base film layer [11, 12]. …”

Section: Introductionmentioning

confidence: 99%

“…The presented research evaluates also the mechanical resistance of the films against puncture which is not usually published in scientific literature [19]. Moreover, the new modification of solvent casting method, the method of impregnation first described by Vetchý et al [12], was used, evaluated, and compared to unmodified solvent casting method. The presented research illustrates the advantages of this innovative approach for evaluating oral mucoadhesive films' properties.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis

Landová

Vetchý

Gajdziok

et al. 2014

BioMed Research International

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Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis

Landová

Vetchý

Gajdziok

et al. 2014

BioMed Research International

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“…Circular bilayer samples (diameter 15 mm) for in vivo testing were punched from the films using a steel punch. These films showed no adverse feelings affecting their residence time and exhibited the most prolonged in vivo film residence time .…”

Section: Methodsmentioning

confidence: 90%

Buccal films as a dressing for the treatment of aphthous lesions

Daněk

Gajdziok

Doležel

et al. 2017

J Oral Pathology Medicine

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The application of buccal films covering aphthous lesions during the treatment significantly increased the rate of healing when compared with the standard methods of treatment. While the pain improvement was statistically significant as soon as Day 3 in the experimental group, it was only apparent on Day 5 in the control group, and the number of successfully treated patients (pain perception improving to visual analogue scale 2 or less) was at all time points higher in the experimental group than in the control group. The results imply that the use of buccal films for treatment of aphthous lesions is very promising and can lead to a significant reduction in the duration of patients' discomfort.

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“…The mucoadhesive and texture properties facilitate the hydrogels adhesion to the biological surface and impact the applicability of the formulation, which thereby improves the efficiency of local therapy. The mechanism of the hydrogel mucoadhesion phenomenon mainly involves the formation of non-covalent, hydrogen, or ionic bonds, or van der Waal's interactions and, therefore, promotes entanglement between the adhesion layer and polymer [20,21]. Hydrogels containing 5 and 10 mg/mL of dry tormentil extract (H-5 and H-10) exhibited beneficial mucoadhesive properties in the experiments conducted using three various models of adhesive layers: porcine buccal mucosa, mucin, and gelatin discs.…”

mentioning

confidence: 99%

Hydrogel Containing an Extract of Tormentillae Rhizoma for the Treatment of Biofilm-Related Oral Diseases

Sosnowska

Pleszczyńska

Jakub

et al. 2017

Natural Product Communications

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In the present study, hydrogels containing the dried extract of tormentil (Potentilla erecta (L.) Raeusch., Rosaceae) were designed and qualitatively evaluated regarding their viscosity, thixotropy, and texture properties. As mucoadhesiveness is a crucial factor determining drug retention within the oral cavity, mucoadhesive properties expressed as the work of adhesion and maximum detachment force under the presence of porcine buccal mucosa and two different models of mucoadhesive layers: mucin and gelatin discs were evaluated. The fingerprints of the analyzed tormentil extract were established by using a LC-ESI-MS method. The dominating compounds of the tested extract are oligomeric proanthocyanidins and agrimoniin. This study reveals that designed hydrogels are promising semi-solid delivery systems for the dry extract of tormentil with beneficial mucoadhesive, thixotropic, and texture characteristics and may be utilized as platforms for tormentil delivery to the oral cavity in periodontal diseases. In vitro evaluation of the efficacy of the tormentil hydrogel against cariogenic Streptococcus mutans biofilms was also performed. The hydrogel significantly reduced artificial biofilm formation. For all Streptococci, complete inhibition was revealed at a final concentration of the extract of 2 mg/mL. These beneficial characteristics, as well as the anti-biofilm activity, enable its use for dental care, but further clinical studies are required.

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Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis

Cited by 28 publications

References 27 publications

Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis

Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis

Buccal films as a dressing for the treatment of aphthous lesions

Hydrogel Containing an Extract of Tormentillae Rhizoma for the Treatment of Biofilm-Related Oral Diseases

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