Determination of diclofenac in pharmaceuticals and urine samples using a membrane sensor based on the ion associate of diclofenac with Rhodamine B

Abstract

Abstract:The potentiometric response characteristics of a diclofenac selective electrode, based on ion association in different plasticizers, were compared. The sensitivity, working range, detection limit and selectivity of membrane sensors demonstrated significant dependence on the type of plasticizers. The potentiometric unit presented a linear response toward diclofenac concentrations between 1 × 10 −5 − 5 × 10 −2 mol L −1 , with slopes of approximately 60 mV dec −1 , and exhibited a response time of 3 s.The potentiometric analysis of sodium diclofenac in pharmaceutical formulations was perfomed by the membrane electrode proposed and compared with the results of potentiometric titration given by the Pharmacopoeia of Ukraine.

Electrochemical investigations of diclofenac at edge plane pyrolytic graphite electrode and its determination in human urine

“…It is also used as an adjuvant in the treatment of chronic diseases such as glaucoma [7]. The therapeutic action of diclofenac is based on its ability to serve as a potent inhibitor of cyclooxygenase enzymes avoiding the production of prostaglandins [8]. Diclofenac is also topically administrated in the form of a 1.16% gel which provides an effective short-term reduction in elbow pain and wrist extensor weakness associated with chronic lateral epicondylitis [9].…”

Taking advantage of CTAB micelles for the simultaneous electrochemical quantification of diclofenac and acetaminophen in aqueous media

“…individual quantication, such as those involving HPLC techniques with UV detector, 8 diffuse reectance photometry, 9 spec-trouorimetry, 10 HPLC with electrochemical detector, 11 aptasensors, 12 membrane sensors with rhodamine B, 13,14 molecularly-imprinted solid-phase extraction and adsorptive differential pulse voltammetry 15 and modifying an edge-plane pyrolytic graphite electrode with single-wall carbon nanotubes. 16 The mixture of DCF and ACT has been shown to decrease morphine consumption during heart surgeries and to reduce postoperative nausea and vomiting 17 and to display greater efficiency than separate drugs, to relieve pain in cesarean patients.…”

Synthesis and Characterization of Electrochemical Sensor Based on Polymeric /TiO2Nanocomposite Modified with Imidizolium Ionic Liquid for Determination of Diclofenac

“…Various methods have been employed for the analysis of diclofenac, such as spectrophotometry [6][7][8][9][10][11][12][13], high performance liquid chromatography (HPLC) [14][15][16][17][18][19][20], and electroanalytical methods. Compared with other methods, electrochemical methods are simple, selective, more economical, and reasonably short analysis time [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37].…”