Determination of enantiomeric excess using a chiral selective separation mode and polarimetric detection

Lodevico, Romulo G.; Bobbitt, Donald R.; Edkins, Thomas J.

doi:10.1016/s0039-9140(96)02082-6

Cited by 18 publications

(7 citation statements)

References 20 publications

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“…Furthermore, the contribution of polarimetry to resolution techniques is available in the literature. 206,207 In addition to normal polarimetry, laser polarimetry can also be used for chiroptical detection. 208 A laser polarimeter reveals the changes in elution order of stereoisomers.…”

Section: Polarimetrymentioning

confidence: 99%

Racemic drug resolution: a comprehensive guide

Mane

2016

Anal. Methods

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Section: Polarimetrymentioning

confidence: 99%

Racemic drug resolution: a comprehensive guide

Mane

2016

Anal. Methods

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“…4. 12,13 The applied polarimeter was calibrated for three temperatures (T = 20, 30, and 40jC) at a wavelength of 589 nm. A thermostated flow cell of stainless steel with a length of l = 50 mm and an inner volume of V = 160 ml was used.…”

Section: Calibration Of the Analytical Techniquesmentioning

confidence: 99%

Online monitoring of preferential crystallization of enantiomers

2004

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Polarimetry is used for continuous online monitoring of optical resolution by preferential crystallization. In combination with refractometry the liquid phase composition is determined, allowing one to follow the resolution progress quantitatively. The measurement techniques were calibrated up to relatively high solution concentrations and combined with the crystallizer. The resolution of DLthreonine was performed by preferential crystallization experiments in aqueous solution varying several process parameters like supersaturation, seed amount, initial enantiomeric excess, and scale. The resolution progress can be conveniently described by profiles of the optical rotation (polarimetric signal) and the crystallization pathway in the corresponding ternary phase diagram. The method outlined is applicable for dynamic process optimization and control purposes in ''quasi-continuous'' chiral separation processes.

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“…The difference between these concentrations can be determined with a polarimetric detector also equipped with a flow cell. A similar procedure for the quantitative detection of chiral molecules was successfully utilized by Lodevico et al (1997).…”

Section: Analytical System Of the Smb Unitmentioning

confidence: 99%

Simulated moving-bed adsorption for separation of racemic mixtures

Santos

Veredas

Silva

et al. 2004

Braz. J. Chem. Eng.

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-The two enantiomers that constitute a racemate have different activities when employed as pharmaceuticals. Due to this fact, fully recognized today, the pharmaceutical industry has been forced to market pure enantiomers instead of the racemic mixture whenever a chiral compound is involved. The simulated moving bed (SMB) is a chromatographic process that, unlike traditional HPLC systems, operates continuously without losing the enantiomeric purity of the outlet streams. The present work describes the enantioseparation of the anesthetic ketamine in a semipreparative-scale SMB unit. The chiral stationary phase employed was the microcrystalline cellulose triacetate. The outlet streams were analyzed by an on-line system, composed by an UV/VIS meter and a polarimeter, and also by HPLC. The analysis indicated purity values up to 100% for the stream of interest and up to 97.7% for the other stream.

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Determination of enantiomeric excess using a chiral selective separation mode and polarimetric detection

Cited by 18 publications

References 20 publications

Racemic drug resolution: a comprehensive guide

Racemic drug resolution: a comprehensive guide

Online monitoring of preferential crystallization of enantiomers

Simulated moving-bed adsorption for separation of racemic mixtures

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