Determination of farm workers’ exposure to pesticides by hair analysis

Analytical methods for human biomonitoring of pesticides. A review

“…Current LC approaches mainly use silica-based, reversed-phase columns, being the octadecyl carbon chain (C18) the most frequently used phase (Tables 2,3). However, other reversed-phases with phenyl groups are also proposed when more selectivity and retention capacity for polar compounds are required [41,49]. A useful alternative for the highly-polar metabolites such as DAPs, or the quaternary ammonium compounds (paraquat, diquat), which have poor retention in the standard reversed-phase columns, is a hydrophilic interaction liquid chromatography (HILIC) [85] [45].…”

Occurrence of biomarkers of pesticide exposure in non-invasive human specimens

“…Table 3 shows the concentrations of different classes of pesticides from several recent studies. Schummer et al (2012) investigated the presence of 50 pesticides (39 molecules from different chemical families currently used in agriculture and 11 OCs) in a population of 18 farm workers from Luxembourg. They used a sensitive method with LOD from 0.01 to 2 pg mg À1 .…”

Hair Analysis for the Biomonitoring of Human Exposure to Organic Pollutants

“…Since the first reports describing its detection in hair were published in 1998À1999 [1,2], the sensitivity of the methods has been increased by 100 to 1,000 ( Figure 7.2), mainly due to technical progresses in general, and more recently to the use of solid phase microextraction associated with gas chromatography tandem mass spectrometry (GC-MS/MS) [38]. A good illustration of the gain in analytical sensitivity can be observed through studies focusing on Luxembourg population [1,39,40]: the first analysis of lindane in hair conducted in 1998 only provided negative results (below limit of detection) whereas the studies carried out 14 years later on similar subjects reported 66À100% positive detection. A good illustration of the gain in analytical sensitivity can be observed through studies focusing on Luxembourg population [1,39,40]: the first analysis of lindane in hair conducted in 1998 only provided negative results (below limit of detection) whereas the studies carried out 14 years later on similar subjects reported 66À100% positive detection.…”