Determination of Fluoxetine, Fluvoxamine, and Clomipramine in Pharmaceutical Formulations by Capillary Gas Chromatography

Nevado, J. J. Berzas; Llerena, M. J. Villaseñor; Salcedo, A.M. Contento; Nuevo, E. Aguas

doi:10.1093/chromsci/38.5.200

Cited by 58 publications

(18 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several instrumental methods have been proposed for the determination of FXT in pharmaceutical samples and biological fluids including liquid chromatography, [5][6][7] gas chromatography, 8,9) spectrofluorimetry, 10,11) and capillary electrophoresis. 12,13) Most of the spectrophotometric methods reported for determination of FXT involve difficult and timeconsuming extraction procedures.…”

Section: Fluoxetine (Fxt) Hydrochloride N-methyl-3-phenyl-3-[4-mentioning

confidence: 99%

Spectrophotometric Determination of Fluoxetine by Batch and Flow Injection Methods

Afkhami

Madrakian

Khalafi

2006

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

Section: Fluoxetine (Fxt) Hydrochloride N-methyl-3-phenyl-3-[4-mentioning

confidence: 99%

Spectrophotometric Determination of Fluoxetine by Batch and Flow Injection Methods

Afkhami

Madrakian

Khalafi

2006

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…This is quite striking because this high-boiling-point analyte typically requires very long run times and (or) lengthy derivatization steps to analyze it by conventional GC methods. 20 As a result, it is normally determined using HPLC or capillary electrophoresis. 21,22 It is also interesting to note that this analyte could also be directly analyzed in aqueous solution in the ultrashort GC column system.…”

Section: System Operating Characteristicsmentioning

confidence: 99%

A novel ultrashort capillary gas chromatography method using on-column injection and detection

2016

View full text Add to dashboard Cite

A novel method for ultrashort capillary column gas chromatography (GC) analysis is introduced, which employs on-column injection and detection and rapid temperature programming. Using 10-20 cm long capillary columns, results showed that the method provides efficient and very rapid separations for relatively simple mixtures. Moreover, the on-column aspect of the method used here is demonstrated to avoid the extra column analyte degradation that can occur in traditional approaches to such separations. As a result, the developed method allows for the first time the GC analysis of some very large and (or) highly thermally labile analytes, such as polypeptides and drug molecules that are normally prone to decomposition. As an application, this method is further used to monitor pharmaceutical degradant formation as a function of temperature and was found to provide similar results to those obtained from conventional high-performance liquid chromatography analysis. Overall, the findings indicate that this ultrashort GC column approach could be useful in these areas and potentially others, where relatively simple GC analysis and universal flame ionization detection is desirable.Key words: ultrashort column, gas chromatography, flame ionization detection, on-column injection, rapid heating.Résumé : Nous présentons une nouvelle méthode d'analyse par chromatographie en phase gazeuse (CPG) sur colonne capillaire ultracourte, dans laquelle est employé un système d'injection et détection sur colonne et un réglage de chauffage rapide. Avec des colonnes capillaires de longueurs allant de 10 à 20 cm, les résultats indiquent que la méthode permet des séparations efficaces et très rapides de mélanges relativement simples. En outre, nous avons démontré que l'aspect « sur colonne » de la méthode dont il est question permet de limiter la dégradation des analytes dans la colonne, qui peut se produire au cours de ce type de séparation par les méthodes classiques. Par conséquent, la méthode mise au point permet de réaliser pour la première fois l'analyse par CPG de certains analytes très volumineux ou très thermolabiles comme les polypeptides et les molécules thérapeutiques normalement sujettes à la décomposition. En ce qui concerne son application, la méthode peut également être utilisée pour surveiller la formation des produits de dégradation pharmaceutiques en fonction de la température et se révèle utile pour produire des résultats similaires à ceux qui sont obtenus par l'analyse conventionnelle par chromatographie en phase liquide à haute performance. En conclusion, les résultats indiquent que cette méthode employant une colonne de CPG ultracourte peut être utile dans ces domaines, et éventuellement dans d'autres domaines où une analyse par CPG relativement simple avec une détection à ionisation de flamme est souhaitable. [Traduit par la Rédaction] Mots-clés : colonne ultracourte, chromatographie en phase gazeuse, détection à ionisation de flamme, injection sur colonne, chauffage rapide.

show abstract

“…A survey of literature revealed that spectrophotometric 3,4 , spectrofluorimetric 5,6 , electrochemical 7 , gas chromatography 8 , liquid chromatography [9][10][11] , capillary zone electrophoresis (CZE) 12 methods for determination of FH from pharmaceutical formulation and spectrophotometric [13][14][15][16][17] , linear voltametric 16 , HPLC [16][17][18] , CZE 18 methods for determination of OZ from pharmaceutical dosage form whereas HPLC [19][20][21][22] and HPTLC 21,22 methods for the simultaneous determination of FH and OZ from combined dosage forms were reported.…”

Section: Fig 1b: Olanzapine Figure 1a and B: Chemical Structures Of Flmentioning

confidence: 99%

Untitled

2011

IJPSR

View full text Add to dashboard Cite

Fluoxetine hydrochloride (FH) in combination with Olanzapine (OZ) is used in treatment of depressive episodes associated with bipolar disorder. The first derivative spectrophotometric method for simultaneous determination of fluoxetine hydrochloride (FH) and olanzapine (OZ) from two component tablet dosage form has been developed and validated. Chromatographic methods viz. HPLC and HPTLC methods were reported in the literature for the simultaneous determination of FH and OZ from combined dosage forms. In the present investigation an attempt has been made to develop accurate, reproducible, rapid and cost-effective method for simultaneous determination of FH and OZ in pharmaceutical formulation. The wavelengths selected for determination of FH and OZ is 235.5nm and 296nm, respectively. The beer's law was obeyed in the concentration range of 8-80μg/mL and 2-20μg/mL for Fluoxetine and Olanzapine, respectively. The proposed methods were validated and successfully applied to the determination of FH and OZ in tablet formulations. The results suggested that the proposed procedures can be used for routine quality control of tablets containing FH and OZ.

show abstract

Determination of Fluoxetine, Fluvoxamine, and Clomipramine in Pharmaceutical Formulations by Capillary Gas Chromatography

Cited by 58 publications

References 8 publications

Spectrophotometric Determination of Fluoxetine by Batch and Flow Injection Methods

Spectrophotometric Determination of Fluoxetine by Batch and Flow Injection Methods

A novel ultrashort capillary gas chromatography method using on-column injection and detection

Untitled

Contact Info

Product

Resources

About