Spectrophotometric Determination of Fluoxetine by Batch and Flow Injection Methods

Abstract

A rapid, simple, and accurate spectrophotometric method is presented for the determination of fluoxetine by batch and flow injection analysis methods. The method is based on fluoxetine competitive complexation reac

Simple Determination of Deoxycholic and Ursodeoxycholic Acids by Phenolphthalein‐β‐Cyclodextrin Inclusion Complex

“…The best pH condition found for determining DCA was 10.5 and similar to that proposed for fluoxetine and tetrahydrofurane by Afkhami et al [20] and Zarzycki and Lamparczyk [33], respectively. The development of low cost methods for determining DCA is important in quality control of pharmaceutical formulations, for example, in deoxycholate-hydrogels [34] to prevent misuse when considering aesthetic usage purposes.…”

“…Then, if the K-value is high, it means that the inclusion complex is stable, as is the case of the b-CD-PHP, a colorless 1:1 inclusion complex [20,21] at pH 10.5 and 25°C, obtained in this work which is the method reagent proposed. In this way, only hydrophobic molecules with high affinity to the cyclodextrin cavity will be able to replace the PHP in the b-CD cavity, causing spectral changes in the visible spectrum.…”

Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR

“…Two of them were the brand formulations from LILLY (Prozac ® ) and SOLVAY Pharma (Floxyfral ® ), the others were generic drugs from different countries. The declared amounts of the active ingredient in the various Table 1 Commercial formulations of fluoxetin (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and fluvoxamine (16)(17)(18)(19) All samples, as received, were stored in the dark at ambient temperature and humidity. They were all analysed within expiry dates.…”

Determination of fluoxetine in the presence of photodegradation products appearing during UVA irradiation in a solid phase by chromatographic-densitometric method, kinetics and identification of photoproducts

“…Fluoxetine was also determined in pharmaceutical preparations [7,[20][21][22][23] and in biological material [24] by thin-layer chromatography (TLC) and high-performance thin-layer chromatography (HPTLC). In addition to separation techniques, the following methods were used: spectrophotometry [25][26][27], derivative spectrophotometry [28], spectrofluorimetry [29,30], potentiometry [31], voltamperometry [32], and conductometry [33].…”