Determination of Fluoxymesterone, Norethandrolone, Prednisolone, and Prednisone in Tablets by Differential Pulse Polarography

Yadav, Ram Narayan; Teare, Fred W.

doi:10.1002/jps.2600670352

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…These mainly include: high-performance liquid chromatography [2][3][4][5][6][7], capillary gas chromatography [8][9][10][11][12][13][14], radioimmunological and chromato-mass fragmentography [1], argentometry [15] and differential-pulse polarography [16][17][18][19]. Adsorptive cathodic stripping voltammetry has been shown as an efficient analytical technique for trace determination of a wide range of drugs, which have an interfacial adsorptive character onto surface of the working electrode.…”

Section: Introductionmentioning

confidence: 99%

Voltammetry and quantification of the contraceptive drug norethisterone in bulk form and pharmaceutical formulation

Ghoneim

Abushoffa

Moharram

et al. 2007

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 99%

Voltammetry and quantification of the contraceptive drug norethisterone in bulk form and pharmaceutical formulation

Ghoneim

Abushoffa

Moharram

et al. 2007

Journal of Pharmaceutical and Biomedical Analysis

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“…Chromatography coupled with various detection techniques is the dominant analytical method for quantification of prednisone and its metabolites (2)(3)(4)(5)(6)(7). However, there are also examples of polarographic (8,9) and voltammetic (10) analyses of prednisone metabolites in biological samples.…”

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confidence: 99%

Quantitative Determination of Prednisone in Tablets by Infrared Attenuated Total Reflection and Raman Spectroscopy

Mazurek

Szostak

2012

Journal of AOAC INTERNATIONAL

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The quantification of prednisone in tablets was performed using partial least squares (PLS) models based on FTIR-attenuated total reflection (ATR) and FT-Raman spectra. To compare the predictive ability of these models, the relative standard error of prediction (RSEP) values were calculated. In the case of prednisone determination from the FT-Raman data, RSEP values of 3.1 and 3.2% for the calibration and validation data sets were obtained. For FTIR-ATR models, which were constructed using five spectra for each sample, these errors amounted to 2.6 and 2.9%, respectively. Four commercial products containing 1, 5, 10, and 20 mg prednisone/tablet were quantified. Concentrations derived from the elaborated models correlated strongly with the results of reference analyses and with the declared values (in parentheses). The analyses gave recoveries of 100.0-101.6% (100.1-103.0%) and 98.1-103.2% (100.4-102.9%) for FTIR-ATR and FT-Raman data, respectively. A successful quantification of prednisolone in tablets containing 5 mg active ingredient/tablet was also performed using the PLS model, which was based on FTIR-ATR spectra, with a recovery of 99.8 (98.8%). Both reported spectroscopic techniques can be used as fast and convenient alternatives to the standard pharmacopeial methods of prednisone and prednisolone quantification in solid dosage forms. However, in the case of FTIR-ATR spectroscopy, it is necessary to repeat measurements several times to obtain sufficiently low quantification errors.

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Determination of steroids in pharmaceutical formulations

Gǒrög

1981

Z. Anal. Chem.

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Determination of Fluoxymesterone, Norethandrolone, Prednisolone, and Prednisone in Tablets by Differential Pulse Polarography

Cited by 10 publications

References 16 publications

Voltammetry and quantification of the contraceptive drug norethisterone in bulk form and pharmaceutical formulation

Voltammetry and quantification of the contraceptive drug norethisterone in bulk form and pharmaceutical formulation

Quantitative Determination of Prednisone in Tablets by Infrared Attenuated Total Reflection and Raman Spectroscopy

Determination of steroids in pharmaceutical formulations

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