Determination of hair nicotine by gas chromatography–mass spectrometry

Man, Che Nin; Ismail, Syazwani; Harn, Gam Lay; Lajis, Razak; Awang, Rahmat

doi:10.1016/j.jchromb.2008.12.014

Cited by 47 publications

(28 citation statements)

References 28 publications

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“…Consumption of psychotropic substances by modern populations has been widely assessed through analysis of residues in hair (Srogi, 2006;Man et al, 2009). However, such studies have been particularly enlightening in archaeological contexts (Wilson, 2005).…”

Section: Introductionmentioning

confidence: 99%

Nicotine in the hair of mummies from San Pedro de Atacama (Northern Chile)

Echeverría

Niemeyer

2013

Journal of Archaeological Science

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Section: Introductionmentioning

confidence: 99%

Nicotine in the hair of mummies from San Pedro de Atacama (Northern Chile)

Echeverría

Niemeyer

2013

Journal of Archaeological Science

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“…In relation to tobacco biomarkers, several MS methods have been described for hair nicotine and cotinine concentrations in smokers and nonsmokers as biomarkers of active smoking and exposure to environmental tobacco smoke (ETS) ( Table 2) [80,97,[99][100][101][102]. In 2004, Chetiyanukornkul et al [100] published a method to determine the presence of nicotine and cotinine in hair based on LC-MS, but with low sensitivity and needing a large amount of hair (50 mg).…”

Section: Analytical Methods For Determination Of Nicotine and Cotinine mentioning

confidence: 99%

Maternal and Neonatal Hair and Breast Milk in The Assessment of Perinatal Exposure to Drugs of Abuse

et al. 2015

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Perinatal exposure to one or more drugs of abuse can affect the neonate temporarily or permanently. In addition to meconium, the evaluation of perinatal exposure to drugs of abuse has been achieved by testing biological matrices coming from the newborn (neonatal hair) and from the pregnant or nursing mother (maternal hair and breast milk). These matrices have the advantage of noninvasive collection and account for a sizable time window of active and passive exposure. Sensitive and specific analytical methods are required to determine minute amounts of drugs of abuse and metabolites in these matrices. The present manuscript reviews the newest analytical methods developed to detect drugs of abuse as well as ethanol biomarkers in maternal and neonatal hair and breast milk.

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“…The sensitivity of this assay, which was determined by limit of detection (LOD) less than 0.010 ng/mg and limit of quantitation (LOQ), was achieved at 0.040 ng/mg when 5 mg of hair was used. The accuracies and precisions within-and between-assays were less than 11.4 % [23]. The quantifying ions used were m/z 162 for nicotine and m/z 169 for internal standard [16,24].…”

Section: Hair Nicotine Analysismentioning

confidence: 96%

“…Hair nicotine analysis was determined according to the previous literature using gas chromatography-mass spectrometry (GC-MS) [23]. Preparation of reagents and analysis of hair nicotine were performed by the laboratory technician at the National Poison Centre of Malaysia.…”

Section: Hair Nicotine Analysismentioning

confidence: 99%

Higher hair nicotine level in children compared to mother living with smoking father in Malaysia

Mohamed

Loy

Man

et al. 2016

Environ Health Prev Med

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Objectives The objectives of this study are to determine parental and children's hair nicotine levels, their relationships as well as to investigate the association of smoking status of the fathers with mothers' and children's hair nicotine. Methods A cross-sectional study design was conducted among 124 families who were participants of the Universiti Sains Malaysia Pregnancy Cohort Study. Both parents with their 2 years old children joined this study. A total of 92 hair samples of fathers, 124 hair samples of mothers and 111 hair samples of children were collected and analyzed by gas chromatography-mass spectrometry. Results Of total, 52.4 % of the fathers reported smoking. None of the mothers were smokers. Hair nicotine levels of fathers were found to be significantly correlated with mothers (r = 0.233, p = 0.026) and children (r = 0.508, p \ 0.001). Children living with smoking fathers had significantly higher median hair nicotine level compared to the children of non-smoking fathers (6.08 vs 0.22 ng/mg, p = 0.046). However, this association was not seen in the mothers. Quantile regression showed significant association between fathers' and children's hair nicotine. Conclusion There is a positive relationship between fathers' hair nicotine with mother's and children's hair nicotine. Living with smoking fathers can contribute to higher hair nicotine levels in children but not in mothers.

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Determination of hair nicotine by gas chromatography–mass spectrometry

Cited by 47 publications

References 28 publications

Nicotine in the hair of mummies from San Pedro de Atacama (Northern Chile)

Nicotine in the hair of mummies from San Pedro de Atacama (Northern Chile)

Maternal and Neonatal Hair and Breast Milk in The Assessment of Perinatal Exposure to Drugs of Abuse

Higher hair nicotine level in children compared to mother living with smoking father in Malaysia

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