Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

Shawish, Hazem M. Abu; Tamous, H.; Shaheen, Asma A.; Abed-Almonem, Khalid I.; Elgamel, Ahmed Awad; Al-lham, Wael S.

doi:10.12991/marupj.259888

Cited by 6 publications

(2 citation statements)

References 36 publications

(38 reference statements)

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“…Haloperidol, an antipsychotic that is prescribed to control the symptoms of acute psychosis, is used in the treatment of schizophrenia and acute psychotic disorders . Haloperidol can also be used in the treatment of neurological disorders such as Gilles de la Tourette syndrome, Huntington's chorea, and acute/chronic brain syndrome .…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive and selective method for the rapid determination and preconcentration of haloperidol by using a magnetite‐molecularly imprinted polymer

İlktaç

Gümüş

Aksuner

et al. 2019

J of Separation Science

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A sensitive and selective method based on the determination of haloperidol with the usage of magnetite‐molecularly imprinted polymer and high‐resolution liquid chromatography has been developed. This novel method is rapid as the detection procedure for haloperidol can be completed within a total time of 1 h. The same imprinted polymer can be used for the determination of haloperidol at least 20 times. The proposed method has been succesfully applied to synthetic urine and serum samples and the recoveries of the spiked samples were in the range of 94.7–100.7%. The limit of detection and limit of quantification of the method were 2.25 and 7.50 μg/L, respectively. Linearity of the calibration graph was observed within the range of 10–250 μg/L. By combining the high capacity, high selectivity, and reusability of the magnetic adsorbent with the dynamic calibration range, high sensitivity and high resolution of liquid chromatography with quadrupole time‐of‐flight mass spectrometry, the proposed method is an ideal method for the determination and preconcentration of trace levels of haloperidol. A magnetite‐molecularly imprinted polymer has been used for the first time as a selective adsorbent for the determination of haloperidol.

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Section: Introductionmentioning

confidence: 99%

Highly sensitive and selective method for the rapid determination and preconcentration of haloperidol by using a magnetite‐molecularly imprinted polymer

İlktaç

Gümüş

Aksuner

et al. 2019

J of Separation Science

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“…In addition, MSSM involves construction of the calibration curve of every selected ion as well as that of the drug ion separately. By extrapolation to 0, it is possible to get the selectivity coefficient from this [33,34].…”

Section: Effect Of Interfering Ionsmentioning

confidence: 99%

Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine)

et al. 2020

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Accurate, rapid and inexpensive determination of gemcitabine, an anticancer drug, is of high interest. This manuscript describes the use of potentiometric sensors as a basis for this work given their known attractive characteristics that meet our needs. Potentiometric sensors were comprised of carbon paste S1, coated wire S2 and PVC membrane S3, of gemcitabine (an anticancer drug) were fabricated, studied and evaluated. The calibration plots for these electrodes showed a Nernstian slope of 58.4±0.3, 59.5±0.3 and 58.3±0.3 mV per decade with the limit of detection: 6.50×10-5, 7.20×10-5 and 4.60×10-5 for sensors S1, S2 and S3, respectively. The electrodes have a short and stable response time of ~5 seconds and good reproducibility in a pH range of 2.5-9.5. The present sensors show distinct selectivity toward the drug ion in comparison to several inorganic ions, sugars, amino acids and some common drug excipients. Gemcitabine was determined successfully in ampoules and urine using these sensors by the calibration curve method.

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Lowering detection limits of copper(II)-selective carbon paste electrodes using an SNO- and an SNNS- Schiff base ligands

Saadeh

Shawish

Foul

2022

Sensors International

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Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

Cited by 6 publications

References 36 publications

Highly sensitive and selective method for the rapid determination and preconcentration of haloperidol by using a magnetite‐molecularly imprinted polymer

Highly sensitive and selective method for the rapid determination and preconcentration of haloperidol by using a magnetite‐molecularly imprinted polymer

Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine)

Lowering detection limits of copper(II)-selective carbon paste electrodes using an SNO- and an SNNS- Schiff base ligands

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