Determination of lidocaine and active metabolites in blood serum by liquid chromatography with electrochemical detection

Halbert, Mary Kim; Baldwin, Richard P.

doi:10.1016/s0378-4347(00)80889-0

Cited by 21 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lidocaine is a local anaesthetic and is one of the most studied drugs for both the detection and isolation of a drug metabolite using electrochemical methods [98][99][100][101][102]. The major metabolite of lidocaine is the N-deethylated form.…”

Section: New Drug Op Measurements and Stability Inferencementioning

confidence: 99%

Voltammetric Behaviour of Drug Molecules as a Predictor of Metabolic Liabilities

et al. 2020

View full text Add to dashboard Cite

Electron transfer plays a vital role in drug metabolism and underlying toxicity mechanisms. Currently, pharmaceutical research relies on pharmacokinetics (PK) and absorption, distribution, metabolism, elimination and toxicity (ADMET) measurements to understand and predict drug reactions in the body. Metabolic stability (and toxicity) prediction in the early phases of the drug discovery and development process is key in identifying a suitable lead compound for optimisation. Voltammetric methods have the potential to overcome the significant barrier of new drug failure rates, by giving insight into phase I metabolism events which can have a direct bearing on the stability and toxicity of the parent drug being dosed. Herein, we report for the first time a data-mining investigation into the voltammetric behaviour of reported drug molecules and their correlation with metabolic stability (indirectly measured via t½), as a potential predictor of drug stability/toxicity in vivo. We observed an inverse relationship between oxidation potential and drug stability. Furthermore, we selected and prepared short- (<10 min) and longer-circulation (>2 h) drug molecules to prospectively survey the relationship between oxidation potential and stability.

show abstract

Section: New Drug Op Measurements and Stability Inferencementioning

confidence: 99%

Voltammetric Behaviour of Drug Molecules as a Predictor of Metabolic Liabilities

et al. 2020

View full text Add to dashboard Cite

show abstract

“…As far as forensic toxicological identification, analytical methods for lidocaine are well developed and documented [9][10][11]. However, there is no obvious evidence indicated the cause of death in anesthesia, difficult to distinguish the cause of death between accident and natural.…”

Section: Introductionmentioning

confidence: 99%

Postmortem Redistribution of Lidocaine after Epidural Anesthesia Accidental Death

Wei¹,

Yu²,

Zhang³

et al. 2017

J Forensic Res

View full text Add to dashboard Cite

Epidural anesthesia is often used form in Chinese primary hospitals and lidocaine is the most favorite anesthetic. Fatalities due to epidural anesthesia accident and lidocaine overdose are often happened, but there still have not obvious evidence to indicate the real reason of death according to the concentration of lidocaine in postmortem blood because the postmortem redistribution (PMR). An animal models using dogs has been developed, whereby the dogs received an intravenous, subarachnoid, and epidural injection of lidocaine (75 mg/kg body weight). The dogs were placed at room temperature after sacrifice. The cardiac blood, inferior vena cava blood, liver and cerebrum samples were collected at 0 h, 1 h, 4 h, 8 h, 24 h, 48 h and 72 h postmortem with the same animal's corpse. The lidocaine is easier diffusion from canalisvertebralis to cardiac blood in subarachnoid administration. The level commonly has a great change from 48 h after death in cardiac blood, from 35.7 mg/L to 1421.9 mg/L, and then decreasing 50% at 72 h. The inferior vena cava blood concentration was stabilized in postmortem time. The cerebrum concentration of subarachnoid administration decreased by 50% and was observed at 72 h after death. The changes were observed in cardiac blood in intravenous and epidural administration groups, but no changes were observed in cerebrum. Lidocaine concentrations did not change significantly in the liver in any of the three groups. This study can assist toxicologists to determine which specimens should be the most appropriately during the interpretation of lidocaine concentrations in epidural accidents.

show abstract

“…19 Lidocaine is an aromatic amide that is widely used as a local anesthetic. 20 It is used in topical anesthesia, intradermal inltration, and peripheral nerve blocks. 21 It is used topically to relieve itching, burning and pain from skin inammations and injected as a dental anesthetic and in minor surgery.…”

Section: Introductionmentioning

confidence: 99%

“…21 The normal level of lidocaine required to be effective in serum is 1-6 pg mL À1 and its metabolites produce toxicity in the body concentrations higher than 6 pg mL À1 . 20 Cases have been reported of accidental fatalities and suicides following intravenous injection of lidocaine, medical homicide and extreme negligence occurring in epidural anesthesia, as well as death due to high spinal anesthesia. 22,23 Cases have also been reported wherein lidocaine was found to be associated with cocaine in drug users.…”

Section: Introductionmentioning

confidence: 99%

Lab-on-phone citrate-capped silver nanosensor for lidocaine hydrochloride detection from a biological matrix

et al. 2015

View full text Add to dashboard Cite

show abstract

Determination of lidocaine and active metabolites in blood serum by liquid chromatography with electrochemical detection

Cited by 21 publications

References 18 publications

Voltammetric Behaviour of Drug Molecules as a Predictor of Metabolic Liabilities

Voltammetric Behaviour of Drug Molecules as a Predictor of Metabolic Liabilities

Postmortem Redistribution of Lidocaine after Epidural Anesthesia Accidental Death

Lab-on-phone citrate-capped silver nanosensor for lidocaine hydrochloride detection from a biological matrix

Contact Info

Product

Resources

About