Determination of preservatives in cosmetic products by reversed-phase high-performance liquid chromatography

Gagliardi, Luigi; Amato, A.; Basili, A.; Cavazzutti, G.; Gattavecchia, E.; Tonelli, Domenica

doi:10.1016/s0021-9673(01)90771-x

Cited by 31 publications

(8 citation statements)

References 16 publications

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“…The analysis was carried out on a YMC-Triart C18 column (5 µm, 150 mm x 4.6 mm) with a flow rate of 1.0 ml/min. A modified gradient mobile phase from previous publications [2,7], consisted of acetonitrile and buffer solution, was utilized ( Table 1). The buffer solution consisted of 0.05 M Na 2 HPO 4 .2H 2 O and adjusted to pH 6.0 with 85% H 3 PO 4 .…”

Section: Hplc Instrumentation and Conditionmentioning

confidence: 99%

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Simultaneous HPLC Determination of Lidocaine Hydrochloride and Hexachlorophene in a Suppository Product

Furwanti

Hendrajaya

Indrayanto

2020

MPI

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Antihemoroid® suppository has been produced commercially by PT. Kimia Farma, Indonesia. For QC purposes, a separated densitometric method for analysis of its active ingredients, lidocaine hydrochloride and hexachlorophene, was applied. The objective of this study was obtaining more efficient analysis method of LH and HC, therefore an HPLC procedure has been developed for the determination of both compounds simultaneously. AYMC-Triart C18 column was used with a gradient mobile phase consisting of acetonitrile and phosphate buffer 0.05 M (pH 6.0). Quantitative evaluation was performed at 220 nm. Method validation was performed according to the new methods of USP 41. Result showed that the HPLC method was simple, accurate, precise, and robust. The HPLC method can be applied in simultaneous determination of LH and HC in suppositories as a QC tool in the pharmaceutical industries.

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Section: Hplc Instrumentation and Conditionmentioning

confidence: 99%

“…Determination of LH with other active pharmaceutical ingredient (API) in injections and mouthwash were also published previously [5][6]. Gagliardi et al [7] reported the analysis of mix tures of HC and other preservatives in cosmetic preparations by HPLC.…”

Section: Introductionmentioning

confidence: 98%

Simultaneous HPLC Determination of Lidocaine Hydrochloride and Hexachlorophene in a Suppository Product

Furwanti

Hendrajaya

Indrayanto

2020

MPI

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“…Therefore, accurate analysis of preservative levels in various cosmetics products is important and required for quality control, product release and regulatory purposes. Currently, high‐performance liquid chromatography (HPLC) has been widely used by the industry for the determination of preservatives in foods, cosmetics and pharmaceuticals . However, the major drawback of the conventional HPLC is the large amount of organic solvents required in the mobile phase.…”

Section: Introductionmentioning

confidence: 99%

Industrial application of green chromatography – II. Separation and analysis of preservatives in skincare products using subcritical water chromatography

Yang

Kapalavavi

Gujjar

et al. 2012

Intern J of Cosmetic Sci

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Several high-temperature liquid chromatography (HTLC) and subcritical water chromatography (SBWC) methods have been successfully developed in this study for separation and analysis of preservatives contained in Olay skincare creams. Efficient separation and quantitative analysis of preservatives have been achieved on four commercially available ZirChrom and Waters XBridge columns at temperatures ranging from 100 to 200°C. The quantification results obtained by both HTLC and SBWC methods developed for preservatives analysis are accurate and reproducible. A large number of replicate HTLC and SBWC runs also indicate no significant system building-up or interference for skincare cream analysis. Compared with traditional HPLC separation carried out at ambient temperature, the HTLC methods can save up to 90% methanol required in the HPLC mobile phase. However, the SBWC methods developed in this project completely eliminated the use of toxic organic solvents required in the HPLC mobile phase, thus saving a significant amount of money and making the environment greener. Although both homemade and commercial systems can accomplish SBWC separations, the SBWC methods using the commercial system for preservative analysis are recommended for industrial applications because they can be directly applied in industrial plant settings.

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“…For the determination of parabens in food, cosmetics and pharmaceutical formulations, the most commonly used analytical column is C18 [12][13][14][15][16][17][18][19][20]. The use of cyano column has also been reported [5,21].…”

Section: Introductionmentioning

confidence: 99%

A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation

Kokoletsi¹,

Kafkala²,

Tsiaganis³

2005

Journal of Pharmaceutical and Biomedical Analysis

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Determination of preservatives in cosmetic products by reversed-phase high-performance liquid chromatography

Cited by 31 publications

References 16 publications

Simultaneous HPLC Determination of Lidocaine Hydrochloride and Hexachlorophene in a Suppository Product

Simultaneous HPLC Determination of Lidocaine Hydrochloride and Hexachlorophene in a Suppository Product

Industrial application of green chromatography – II. Separation and analysis of preservatives in skincare products using subcritical water chromatography

A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation

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