1981
DOI: 10.1093/clinchem/27.12.2064
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Determination of procainamide and N-acetylprocainamide by "high-performance" liquid chromatography.

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Cited by 18 publications
(4 citation statements)
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“…Procainamide and NAPA were analysed in plasma and urine by the h.p.l.c. method of Stearns (1981). Minor modifications of the mobile phase allowed separation of procainamide, NAPA and internal standard (Npropionyl-procainamide) from the potentially interfering compound, caffeine.…”
Section: Assaysmentioning
confidence: 99%
“…Procainamide and NAPA were analysed in plasma and urine by the h.p.l.c. method of Stearns (1981). Minor modifications of the mobile phase allowed separation of procainamide, NAPA and internal standard (Npropionyl-procainamide) from the potentially interfering compound, caffeine.…”
Section: Assaysmentioning
confidence: 99%
“…A small number of methods has been devised to quantitate PA and NAPA simultaneously in plasma by Thin Layer Chromatography (TLC) [ 13 , 14 ], Gas-Liquid Chromatography (GLC) [ 15 ], and HPLC [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], but most lack sensitivity and/or specificity. Although several UV-HPLC methods achieved sensitivity and specificity improvements, they require multistep sample preparations that involve Liquid–Liquid Extraction (LLE), evaporation, and reconstitution.…”
Section: Introductionmentioning
confidence: 99%
“…Although several UV-HPLC methods achieved sensitivity and specificity improvements, they require multistep sample preparations that involve Liquid–Liquid Extraction (LLE), evaporation, and reconstitution. In addition, large sample volumes (0.2–2.5 mL) and injection volumes (10–100 µL) are required [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ] ( Table S1 ). To our knowledge, no method for the simultaneous determination of PA and NAPA by Ultra-High-Pressure Liquid Chromatography (UHPLC) has been described to focus on the analytical application of preclinical studies.…”
Section: Introductionmentioning
confidence: 99%
“…It is a sodium channel blocker which blocks open sodium channels and prolongs the cardiac action potential. This drug is used for both supraventricular and ventricular arrhythmias, as indicated in the treatment of premature ventricular contractions, ventricular tachycardia, atrial fibrillation, and paroxysmal atrial tachycardia [12] . The major active metabolite of PAH is N–acetylprocainamide (NAPA), which is approximately equipotent to the parent drug as an antiarrhythmic agent [13] .…”
Section: Introductionmentioning
confidence: 99%