Determination of sulfonamides by liquid chromatography, ultraviolet diode array detection and ion-spray tandem mass spectrometry with application to cultured salmon flesh

Separation of sulfonamides by capillary electrochromatography

“…Cross et al [26] separated a group of sulfanomides by reversed-phase liquid chromatography at pH2.75 and reported the following elution order; SGW <SAA < SISM < ST < SPRY < SMR < SMZ < SCP < SMOZ. A similar elution order was also reported by Pleasance et al [27], when they used an acidic mobile phase consisting of aqueous acetonitrile and 0.1% trifluoroacetic acid and a column packed with Vydac 201TP stationary phase.…”

Retention behavior of multiple sulfonamides in various liquid chromatographic systems

“…It has, however, generally proved difficult to analyze these drugs efficiently within a single isocratic run using the liquid chromatographic methods described in the literature [13]. Complicated chromatographic conditions including two-step isocratic [14,15] or three-step binary isocratic [16] chromatography, one-step [17,18] or two-step [19] linear gradients, an isocratic gradient followed by a linear gradient [20], flow programming [21], or a ternary gradient with flow programming [22] have all been used with varying success to resolve multiple sulfonamide residues. This paper reports the effect of the ionic state of the solutes, the concentration of inorganic buffers, the type and concentration of positively or negatively charged pairing ions, and the temperature of the column on the liquid chromatographic behavior of a series of sulfonamides.…”

Liquid Secondary Ion Mass Spectrometry and Collision-induced Dissociation Mass Spectrometry of Sulfonamide Derivatives of meso-Tetraphenylporphyrin

“…For compound 4, formation of the [(M H) À SO 3 H] Á ion is also observed. The loss of the amine group with cleavage of the sulfur-nitrogen bond, the loss of the sulfonamide group and the loss of the HSOX species were reported for other compounds with sulfonamide groups [13,14].…”

“…The mass spectral behavior of sulfonamides under EI [9] and CI [10][11][12][13] with tandem mass spectrometry (MS/MS) is well documented. MS/MS with ionspray [14,15], electrospray [16,17] and thermospray [18,19] ionization has also been used for the identification of several sulfonamide compounds. The tandem mass spectra can provide information for the characterization of sulfonamides as a class, because sulfonamides show similar fragmentation patterns [14,16].…”