Determination of temperature distribution in tissue for interstitial cancer photothermal therapy

Li, Shaojie; Doughty, Austin; West, Connor L.; Tang, Zhilie; Zhou, Feifan; Chen, Wei R.

doi:10.1080/02656736.2017.1370136

Cited by 23 publications

(24 citation statements)

References 31 publications

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“…To achieve the optimal temperature distribution in tumor tissue that can kill as many tumor cells while keeping tumor proteins viable, local regional interventional PTT was developed. The parameters of laser irradiation were determined according to the tumor size and tissue property, based on our ex vivo model for simulating temperature distribution in the target tissue (45). The interventional PTT+GC resulted in significantly reduced primary tumors and metastases.…”

Section: Discussionmentioning

confidence: 99%

Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine

Zhou

Yang

Zhang

et al. 2018

Clinical Cancer Research

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To develop a synergistic combination therapy for advanced pancreatic cancer, using local phototherapy and immunotherapy, and to determine the efficacy and mechanism of the novel combination therapy using a highly metastatic pancreatic tumor model in mice. Mice bearing Panc02-H7 pancreatic tumors (both subcutaneous and orthotopic) were treated with noninvasive or interventional photothermal therapy, followed by local application of an immunoadjuvant. Tumor growth and animal survival were assessed. Immune cell populations within spleen and tumors were evaluated by FACS and IHC, and cytokine levels were determined by ELISA. Up to 75% of mice bearing subcutaneous tumors treated with combination therapy had complete tumor regression. Local photothermal therapy exposed/released damage-associated molecular patterns, which initiated an immunogenic tumor cell death, resulting in infiltration of antigen-presenting cells and Th1 immunity. Concomitant application of immunoadjuvant amplified Th1 immunity, especially the tumor-specific cytotoxic T lymphocyte response, with increased quantity and quality of T cells. Combination therapy also induced tumor-specific immune memory, as demonstrated by resistance to tumor rechallenge and production of memory T cells. For the treatment of orthotopic tumor, the combination therapy significantly reduced the primary tumors and metastases, and prolonged the animal survival time. This study indicated that combination of local phototherapy and immunotherapy induced a systemic immunity against established tumors and metastases in an aggressive, preclinical pancreatic tumor model, leading to a potential clinical method for patients with advanced pancreatic cancer. .

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Section: Discussionmentioning

confidence: 99%

Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine

Zhou

Yang

Zhang

et al. 2018

Clinical Cancer Research

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“…PTT can directly target and destroy the primary tumor by increasing the temperature of the tumor tissue, a strategy that has been used for ablation of glioma, hepatocellular carcinoma, lung cancer et al 37 , 38 . PTT induces a temperature gradient within the tumor tissue that leads to various biological responses from cell stress to cell death 39 , 40 . An appropriate temperature gradient can cause a high level of cell death with antigen exposure and DAMPs release, including the exposure/release of HSPs (heat shock proteins), ATP (adenosine triphosphate), and HMGB1 (high-mobility group box 1) 39 , 40 .…”

Section: Photothermal Immunotherapymentioning

confidence: 99%

“…PTT induces a temperature gradient within the tumor tissue that leads to various biological responses from cell stress to cell death 39 , 40 . An appropriate temperature gradient can cause a high level of cell death with antigen exposure and DAMPs release, including the exposure/release of HSPs (heat shock proteins), ATP (adenosine triphosphate), and HMGB1 (high-mobility group box 1) 39 , 40 . This type of cell death is called immunogenic cell death (ICD) and it provides potential for enhancing APCs activation and antigen presentation.…”

Section: Photothermal Immunotherapymentioning

confidence: 99%

Cancer photo-immunotherapy: from bench to bedside

Wang¹,

Rao²,

Wang³

et al. 2021

Theranostics

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“…Polymer nanoparticles functionalized with IR820 and doxorubicin were used in ovarian cancer and showed prolonged circulation time and drug accumulation at the target site [232]. It is important to mention that the generated temperature is usually between 42 and 45°C and sometimes higher depending on tumor tissue [233,234].…”

Section: Theranostic Nps Recently Developedmentioning

confidence: 99%

Theranostic Nanoparticles and Their Spectrum in Cancer

Onaciu¹,

Jurj²,

Moldovan³

et al. 2020

Engineered Nanomaterials - Health and Safety

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Nanoparticles offer a lot of advantageous backgrounds for many applications due to their physical, chemical and biological properties. Their different composition (metals, lipids, polymers, peptides) and shapes (spheres, rods, pyramids, flowers and so on) are influenced by the synthesis methods and functionalization procedures. However, in the medical field, researchers focus on the biocompatibility and biodegradability of the nanoparticles in their attempts for a targeted therapy in which the nanocarriers need to bypass certain biological barriers. Moreover, the increased interest in molecular imaging has brought nanoparticles in the spotlight for their applications in two distinct directions: therapy and diagnosis. Furthermore, recent advances in nanoparticle designs have introduced novel nano-objects suitable as both detection and delivery systems at the same time, thus providing theranostic applications.

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Determination of temperature distribution in tissue for interstitial cancer photothermal therapy

Abstract: The device and method developed in this study can provide guidance for choosing the appropriate treatment parameters for optimal photothermal effects, particularly when combined with immunotherapy, for cancer treatment.

Cited by 23 publications

References 31 publications

Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine

Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine

Cancer photo-immunotherapy: from bench to bedside

Theranostic Nanoparticles and Their Spectrum in Cancer

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