Determination of terbutaline sulfate and its degradation products in pharmaceutical formulations using LC

Daraghmeh, Nidal; Al-Omari, Mahmoud M.H.; Sára, Zoltán; Badwan, Adnan A.; Jaber, A. M. Y.

doi:10.1016/s0731-7085(02)00216-9

Cited by 32 publications

(22 citation statements)

References 6 publications

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“…1,2 A literature survey revealed that various analytical methods have been reported for the estimation of TBS; they include UV spectroscopy, 3,4 voltammetry, 5,6 capillary electrophoresis, [7][8][9] chemiluminescence, [10][11][12] high performance liquid chromatography (HPLC), 1,13,14 HPLC-fluorescence detection, 15 HPLC-electrochemical detection, 16,17 HPLCchemiluminescence detection, 18 RP-liquid chromatography, 19 LC-electrochemical detection, 20 column-switching LC, 21 LC-tandem mass spectrometry, 22,23 and high-resolution GC-mass spectrometry analysis. 24 For TBS pharmacokinetic studies, the most useful analytical method is GC-mass spectrometry.…”

Section: Terbutaline Sulfate (Tbs); β-[(Tert-butylamino)methyl]-35-mentioning

confidence: 99%

Stability indicating HPTLC method for determination of terbutaline Sulfate in bulk and from Submicronized dry Powder inhalers

et al. 2010

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A stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been developed for the determination of terbutaline sulfate (TBS) as a bulk drug and in pharmaceutical formulations (submicronized dry powder inhalers). The separation was achieved on TLC aluminum plates precoated with silica gel 60F-254 using chloroform-methanol (9.0:1.0 v/v) as mobile phase. The densitometric analysis was carried out at 366 nm wavelength. Compact spots appeared at Rf = 0.34 ± 0.02. For the proposed procedure, linearity (r 2 = 0.9956 ± 0.0015), limit of quantification (28.35 ng spot -1 ), limit of detection (9.41 ng spot -1 ), recovery (97.06 -99.56%), and precision (≤1.86) were found to be satisfactory. TBS was subjected to acid and alkali hydrolyses, oxidation and photodegradation treatments. The degraded products were well separated from the pure drug. Statistical analysis reveals that the developed method has potential for routine analysis and stability testing of terbutaline sulfate in pharmaceutical drug delivery systems.

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Section: Terbutaline Sulfate (Tbs); β-[(Tert-butylamino)methyl]-35-mentioning

confidence: 99%

Stability indicating HPTLC method for determination of terbutaline Sulfate in bulk and from Submicronized dry Powder inhalers

et al. 2010

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“…Various methods have been developed for the determination of terbutaline sulfate, including spectrophotometry [3], chemiluminescence (CL) [4], flow injection/chemiluminescence [5], gas chromatography [6], high-performance liquid chromatography (HPLC) [7][8][9] and electrophoresis [10][11][12]. However, spectrophotometry, chemiluminescence and flow injection/chemiluminescence methods are usually not possible in the presence of compounds that are frequently found along with terbutaline sulfate in pharmaceutical preparations and biological fluids, due to the interference caused by them.…”

Section: Introductionmentioning

confidence: 99%

Determination of terbutaline sulfate by capillary electrophoresis with chemiluminescence detection

Wang

Zhao

2009

Journal of Chromatography B

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“…Many analytical methods have been developed for determination of terbutaline sulfate in a variety of substrates; these include colorimetry [13], liquid chromatography (LC) [14,15], high-performance liquid chromatography (HPLC) [16,17], liquid chromatography-mass spectrometry (LC-MS) [18], capillary electrophoresis [19], capillary electrophoresis-mass spectrometry (CE-MS) [20,21], enzymelinked immunosorbent assay and capillary electrophoresis [22], infrared Fourier transform spectroscopy combined with artificial neural networks [23], 1 H NMR and RP-LC [24], and plastic membrane electrode [25] techniques. There is, however, a lack of information about chemiluminescence analysis of terbutaline sulfate in the public literature.…”

Section: Introductionmentioning

confidence: 99%

Sensitive flow-injection chemiluminescence determination of terbutaline sulfate based on enhancement of the luminol?permanganate reaction

Wang

Zhang

et al. 2004

Analytical and Bioanalytical Chemistry

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A novel and highly sensitive chemiluminescence (CL) method for the determination of terbutaline sulfate, coupled with flow-injection analysis (FIA), is described in this paper. The method is based on enhancement by terbutaline sulfate of the chemiluminescence emission of the luminol-permanganate system under alkaline conditions. Under the conditions selected the concentration of terbutaline sulfate is proportional to CL intensity in the range 5 x 10(-10)-5 x 10(-7) g mL(-1), with a detection limit of 1.7 x 10(-10) g mL(-1) (3 sigma). The relative standard deviation is 2.8% for 1 x 10(-8) g mL(-1) terbutaline sulfate ( n=11). Ninety samples can be determined per hour. The proposed method has been used to determine terbutaline sulfate in pharmaceutical preparations and in plasma and urine samples with satisfactory results. The possible mechanism of the chemiluminescence reaction is discussed briefly.

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Determination of terbutaline sulfate and its degradation products in pharmaceutical formulations using LC

Cited by 32 publications

References 6 publications

Stability indicating HPTLC method for determination of terbutaline Sulfate in bulk and from Submicronized dry Powder inhalers

Stability indicating HPTLC method for determination of terbutaline Sulfate in bulk and from Submicronized dry Powder inhalers

Determination of terbutaline sulfate by capillary electrophoresis with chemiluminescence detection

Sensitive flow-injection chemiluminescence determination of terbutaline sulfate based on enhancement of the luminol?permanganate reaction

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