Determination of ternary mixtures of penicillin G, benzathine and procaine by liquid chromatography and factorial design study

Ghassempour, Alireza; Davarani, Saied Saeed Hosseiny; Noroozi, Massomeh; Shamsipur, Mojtaba

doi:10.1016/j.talanta.2004.08.042

Cited by 12 publications

(4 citation statements)

References 15 publications

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“…Chromatography, [9] spectrophotometry, [10] and LC‐MS/MS [11] are among the common techniques reported for determination of ProPenG in different samples. However, these techniques suffer from disadvantages including requirements of organic solvents, long analysis time, expensive instrumentation, and in general involve complex sample preparation protocols [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a Novel [diresorcinate‐1,10‐phenanthrolinecobalt(II)] Complex, and Potentiodynamic Fabrication of Poly(DHRPCo)/GCE for Selective Square Wave Voltammetric Determination of Procaine Penicillin G in Pharmaceutical and Biological Fluid Samples

et al. 2022

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This work presents synthesis, and characterization of a novel [diresorcinate‐1,10‐phenanthrolinecobalt(II)] (DHRPCo) complex, and potentiodynamic fabrication of poly(DHRPCo)/GCE for SWV determination of procaine penicillin G (ProPenG) in various pharmaceutical and biological samples. While UV‐Vis and FT‐IR results demonstrated stepwise synthesis of DHRPCo, the CV and EIS results evidenced modification of the surface of GCE by an electroactive polymer film that improved electrode surface area. In contrast to the peak of ProPenG at the unmodified electrode, an irreversible oxidative peak at poly(DHRPCo)/GCE with lower potential and six folds of current enhancement observed, that confirmed electrocatalytic effect of the polymer, SWV response of poly(DHRPCo)/GCE showed linear dependence on concentration of ProPenG in the range 0.1–200 μM, with LoD of 4.9 nM. Spike recovery results in various pharmaceutical and biological samples in the range 98.03–106.50 %, interference recovery in the presence of selected potential interferents at their various levels with associated errors under 3.39 %, and stability of the modifier with analysis time validated the method for determination of ProPenG. Poly(DHRPCo)/GCE was applied for determination of ProPenG in three brands of injection pharmaceutical formulation, human urine, human blood serum, and cow's milk samples. While no ProPenG was detected in the human urine, serum, and cow's milk samples, detected ProPenG in the injection powder samples was within 96.1–101.3 % of company label. The developed method showed superior performance over recently reported methods making it an excellent candidate for determination of ProPenG in real samples.

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Section: Introductionmentioning

confidence: 99%

Synthesis of a Novel [diresorcinate‐1,10‐phenanthrolinecobalt(II)] Complex, and Potentiodynamic Fabrication of Poly(DHRPCo)/GCE for Selective Square Wave Voltammetric Determination of Procaine Penicillin G in Pharmaceutical and Biological Fluid Samples

et al. 2022

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“…As displayed in Table 1, a mixture of aqueous solution of formic acid 0.3% (pH=2.67) and Ace provided the best sensitivity. In addition, trifluroacetic acid (TFA) was added to reduce the interaction of acids with the silica surface [26] . However, negative result was observed as showed in Table 1, could be related to the carboxylic group of the formic acid, which caused a decrease of interaction between silanol group and TFA.…”

Section: Optimization Of Hplc Conditionsmentioning

confidence: 99%

A Method for Determination of Penicillin G Residue in Waste<i> Penicillium chrysogenum</i> Using High Performance Liquid Chromatography

Wang

Liu

Wang

et al. 2015

AMM

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In this study, a rapid and selective method has been developed to determine PENG residues in waste penicillium chrysogenum by using SPE cleanup strategy followed by HPLC. Furthermore, some parameters which influenced the extraction efficiency including extraction mode, solvent and time, while washing solution and eluting solution for SPE were systematically investigated. It should be noted that the extraction process was carried out in a single step by mixing the extraction solvent acetonitrile: formic acid in aqueous solution and chrysogenum samples under ultrasound. The SPE procedure was conducted using Oasis HLB as the clean up cartridge, n-hexane as washing solution, and mixture of acetonitrile and methanol as eluting solution. Under the optimized conditions, the linear of PENG are in the range of 0.1-2000 μg/mL, with the correlation was R2>0.99. In addition, the recoveries of PENG in these samples at three fortification levels of 800-1800mg/kg were 74.98% to 113.47% are obtained, respectively. Moreover, a limits of detection (0.006 mg/kg) and quantification (0.02 mg/kg) could be achieved.

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“…Zhu and Ghassempour et al [1,2] used HPLC to study penicillin G (PG), the limit of detection (LOD) and linear concentration range were 1.1 lg/mL and 10-2400 lg/mL respectively. But it has some shortcomings such as expensive equipment and low sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Rapid monitoring of benzylpenicillin sodium using Raman and surface enhanced Raman spectroscopy

Jiang

Qin

Yin

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Determination of ternary mixtures of penicillin G, benzathine and procaine by liquid chromatography and factorial design study

Cited by 12 publications

References 15 publications

Synthesis of a Novel [diresorcinate‐1,10‐phenanthrolinecobalt(II)] Complex, and Potentiodynamic Fabrication of Poly(DHRPCo)/GCE for Selective Square Wave Voltammetric Determination of Procaine Penicillin G in Pharmaceutical and Biological Fluid Samples

Synthesis of a Novel [diresorcinate‐1,10‐phenanthrolinecobalt(II)] Complex, and Potentiodynamic Fabrication of Poly(DHRPCo)/GCE for Selective Square Wave Voltammetric Determination of Procaine Penicillin G in Pharmaceutical and Biological Fluid Samples

A Method for Determination of Penicillin G Residue in Waste<i> Penicillium chrysogenum</i> Using High Performance Liquid Chromatography

Rapid monitoring of benzylpenicillin sodium using Raman and surface enhanced Raman spectroscopy

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