Determination of the antioxidant activity of phenolic compounds by coulometric detection

Maillard, Marie‐Noëlle; Bonnely, Samuel; Berset, Claudette

doi:10.1016/s0039-9140(99)00331-8

Cited by 117 publications

(56 citation statements)

References 11 publications

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“…The ARP values observed for ascorbic acid, alphatocopherol, gallic acid and BHA in the present study are in line with the results obtained by Brand-Williams, Cuvelier, and Berset (1995), while the value of the ARP for the quercetin is similar to that found by Peyrat-Maillard, Bonnely and Berset (2000). Comparing the values of ARP of the freeze-dried Mucuna pruriens extract to the values of ARP of the other substances tested ( Table I), revealed that the Rajeshwar et al (2005), who claimed that the methanolic extract of M. pruriens exhibits antioxidant activity (as evaluated by the DPPH • method) which is high compared to different substances such as BHT, ascorbic acid, quercetin and alpha-tocopherol.…”

Section: Resultssupporting

confidence: 92%

In vitro evaluation of Mucuna pruriens (L.) DC. antioxidant activity

Longhi

Perez

Lima

et al. 2011

Braz. J. Pharm. Sci.

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Mucuna pruriens (L). Dc is a plant of the Fabaceae family, commonly known as velvet bean, itchy bean, chiporro bean, mucuna, among others. This plant has several medicinal properties, including its potential to treat Parkinson's disease (PD). International studies have shown that this plant surpasses the benefits of the substance levodopa in the treatment of PD. Taking into account that nerve cells are highly sensitive to oxidative substances, this study evaluated the antioxidant activity of mucuna and compared it to that of levodopa. The plant seeds' phenolic concentration was quantified by using the Folin-Denis reagent and the antioxidant activity assays were performed by using three different methods: the reduction of the phosphomolybdenium complex, the reduction of radical 1,1-diphenyl-2-picrylhydrazyl (DPPH • ) and the formation of radical monocation ABTS•+ , from the acid [2-2'-azinobis (3-ethylbenzothiazoline-6-sulfonate)]. Results showed that M. pruriens presents high antioxidant capacity, although not superior to isolated levodopa antioxidant capacity. Therefore, further studies should be performed to elucidate the activity of this plant in humans.Uniterms: Mucuna pruriens. Antioxidant. Phenolic compounds A Mucuna pruriens (L). Dc é uma planta da família Fabaceae, conhecida popularmente como feijão-veludo, fava-coceira, feijão chiporro, mucuna, entre outros. Possui diversas propriedades medicinais, entre elas, o tratamento da doença de Parkinson (DP). Estudos internacionais vêm demonstrando que essa planta possui atividade superior à do fármaco levodopa para o tratamento da DP. O presente estudo avaliou a possibilidade da atividade antioxidante dessa planta auxiliar nesses resultados, uma vez que as células nervosas são altamente sensíveis às substâncias oxidativas. Para isto foi quantificada a concentração fenólica da semente da mucuna e os testes empregados para a avaliação da atividade antioxidante foram o teste de redução do complexo fosfomolibdênio, redução do radical 1,1-difenil-2-picril-hidrazil (DPPH • ) e a formação do radical monocatiônico ABTS •+ , proveniente do ácido [2-2'-azino-bis(3-etil-benzolina-6-sulfonado)]. Essa análise demonstrou que M. pruriens possui alta capacidade antioxidante, no entanto, não superior à levodopa isolada e, portanto, novos estudos devem ser realizados para a elucidação da atividade dessa planta em seres humanos.Unitermos: Mucuna pruriens. Antioxidante. Compostos fenólicos.

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Section: Resultssupporting

confidence: 92%

In vitro evaluation of Mucuna pruriens (L.) DC. antioxidant activity

Longhi

Perez

Lima

et al. 2011

Braz. J. Pharm. Sci.

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“…28 Unfortunately, no relationship could be established for flavonoids. In our understanding, this might be attributed to the evidently overestimated MDRP values.…”

Section: Determination Of the Antioxidant Activitymentioning

confidence: 99%

Estimation of the Antioxidant Activities of Flavonoids from Their Oxidation Potentials

Yang

Kotani²,

Arai³

et al. 2001

ANAL. SCI.

263

171

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A simple electrochemical method for estimating the antioxidant activity (AA) of flavonoids has been developed. The proposed method is based on a measurement of the half-wave potential (E1/2) of the first oxidation wave of flavonoids by using flow-through column electrolysis. At the same time, the lipid peroxidation (LPO) inhibiting effects of these flavonoids were determined. A quantitative structure-activity relationship was obtained to describe the AA of flavonoids: IC50(µM) = 30.36 + 151.50E1/2 (V) -12.63log P (r = 0.852), where IC50 represents the concentration for 50% inhibition of LPO, and P represents the octanol/water partition coefficient. This method is expected to be useful for the quick screening of flavonoid antioxidants, and evaluating the AA of flavonoid-containing foods and medicinal plants.

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“…Numerous volumetric, spectrophotometric, chemiluminescent, fluorescent, electrochemical and other methods have been proposed [14][15][16][17][18][19][20][21]. According to their mechanisms all AOA assays could be divided into hydrogen atom transfer (HAT) and electron transfer (ET) assays.…”

Section: Introductionmentioning

confidence: 99%