Determination of the Cytokine Gene Polymorphism and Genetic Susceptibility in Tuberculosis Patients

Ülger, Mahmut; Emekdaş, Gürol; Aslan, Gönül; Taş, Dilaver; İlvan, Ahmet; Tezcan, Seda; Çalıkoğlu, M. Erem; Kartaloğlu, Zafer

doi:10.5578/mb.4699

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…There are 29 case-control studies concerning -1082G/A polymorphism [16]–[44], 14 case-control studies concerning -819T/C polymorphism [16], [18], [20]–[23], [25], [31], [33], [37]–[39], [42], [45], and 16 case-control studies concerning -592A/C polymorphism [16], [20]–[25], [28], [31], [33], [37]–[40], [45], [46]. Among the 31 eligible studies, 17 of them were of Asians [16], [18], [19], [26], [28], [30]–[32], [34], [36], [39], [41]–[44], [46], 6 studies were of Europeans [17], [21], [25], [27], [35], [37], 5 studies were of Africans [20], [22], [29], [33], [38], and 3 studies were of Americans [23], [24], [40]. Controls were selected from healthy population in all studies and most studies used frequency-matched controls to the cases by age, sex, or ethnicity.…”

Section: Resultsmentioning

confidence: 99%

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

Liang

Guo

et al. 2014

PLoS ONE

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BackgroundA number of observational studies have been conducted to investigate the association of IL-10 gene polymorphisms with tuberculosis (TB) susceptibility. However, the results of different studies were inconsistent. The aim of this study was to investigate the relationship between IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms and TB risk by meta-analysis.MethodsA literature search was conducted among six English databases (PubMed, Embase, Web of Science, Science Direct, SpringerLink and EBSCO) and two Chinese databases (Wanfang and Chinese National Knowledge Infrastructure databases) to identify studies involving association between IL-10 −1082G/A, −819T/C, and −592A/C polymorphisms and TB susceptibility before May. 2013. Statistical analysis was performed using Revman 5.0 and Stata 12.0.ResultsA total of 31 studies with 6,559 cases and 7,768 controls were included in this meta-analysis. The results showed that three polymorphisms (-1082G/A, -819T/C, and -592A/C) in the IL-10 gene were not associated with the risk of TB in general population. In the subgroup analysis by ethnicity, IL-10 -1082G/A polymorphism was associated with TB risk in Europeans (AA+AG vs. GG: OR = 0.57, 95% CI = 0. 0.37–0.89, P = 0.01) and Americans (AA+AG vs. GG: OR = 0.39, 95% CI = 0.27–0.57, P<0.01), and IL-10 -819T/C (C allele vs. T allele: OR = 0.83, 95% CI = 0.72–0.96, P = 0.01) and -592A/C (CC+AC vs. AA: OR = 0.65, 95% CI = 0.49–0.85, P = 0.002) polymorphisms were significantly associated with TB risk in Asians.ConclusionThis meta-analysis provides strong evidence that IL-10-1082G/A polymorphism was associated with TB risk in Europeans and Americans, and IL-10 -819T/C and -592A/C polymorphisms could be risk factors for TB in Asians. Additional well designed large studies were required for the validation of our results.

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Section: Resultsmentioning

confidence: 99%

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

Liang

Guo

et al. 2014

PLoS ONE

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“…The detailed characteristics of the eligible studies included in this meta-analysis are shown in Table 1 , and the genotype and allele distributions of all four polymorphisms are shown in Table 2 . The genotype distributions among the controls of all studies were consistent with the HWE except for eight studies for the IL-10 -1082G/A, 6 11 13 23 25 27 29 34 one study for the IL-10 -819C/T, 36 three studies for the IL-10 -592A/C, 14 33 36 and two studies for the IL-6 -174G/C ( Table 1 ). 6 16 …”

Section: Resultsmentioning

confidence: 55%

“…There are 26 case-control studies concerning IL-10 -1082G/A polymorphism, 6 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 29 30 31 32 33 34 35 15 case-control studies for IL-10 -819C/T polymorphism, 6 10 14 16 17 20 21 22 24 25 28 29 30 32 36 16 case-control studies for IL-10 -592A/C polymorphism, 6 10 14 15 16 17 20 21 24 25 26 29 30 32 33 36 and 7 case-control studies about IL-6 -174G/C polymorphism. 6 16 17 21 25 37 38 Among the 30 eligible studies, 14 of them were of Asians, 6 11 15 18 19 21 22 23 28 30 31 35 37 …”

Section: Resultsmentioning

confidence: 99%

IL-10Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis

Liu

et al. 2015

Yonsei Med J

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PurposeThe association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies.Materials and MethodsBased on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk.ResultsThe results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model.ConclusionThe results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

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“…In addition, the results of SNP association studies focusing on infectious disease other than leishmaniasis were also controversial, too. 24,[46][47][48][49] The discrepancies between these studies may imply that susceptibility to infectious diseases like leishmaniasis could not be explained by only cytokine gene SNPs. Different SNPs in other gene regions should also be studied as it is a very complex disease controlled by multiple genes.…”

Section: Ta B L Ementioning

confidence: 98%

“…Roche Molecular Systems, Inc) according to the manufacturer's instructions. TNF-α promoter −308 G/A, IFN-γ intron +874 T/A and IL-10 promoter −1082 G/A polymorphisms were genotyped by ARMS-PCR method, and IL-12B p40 + 1188 A/C and IL-4 promoter −590 C/T polymorphisms were genotyped by PCR-RFLP method according to the method described by Ülger et al24 …”

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confidence: 99%

Association of cytokine gene polymorphisms with susceptibility to cutaneous leishmaniasis in a Turkish population

Kırık

Ülger

et al. 2020

Parasite Immunology

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Human leishmaniasis is a vector-borne disease caused by intracellular protozoan parasite species belonging to the genus Leishmania (over 20 species), and it is transmitted to human by the bite of infected female phlebotomine sand fly (Phlebotomus spp. in the Old World and Lutzomyia spp. in the New World). 1,2 There are three main clinical forms of Leishmaniasis: cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL) and visceral leishmaniasis (VL). 3 According to the World Health Organization (WHO) fact sheet data, 97 countries are endemic for leishmaniasis and an estimated 700.000-1 million new cases and 26.000-65.000 deaths occur worldwide, annually. An estimated 50.000 to 90.000 new cases of VL occur worldwide each year. In 2017, more than 95% of new VL cases occurred in Bangladesh,

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Determination of the Cytokine Gene Polymorphism and Genetic Susceptibility in Tuberculosis Patients

Cited by 10 publications

References 18 publications

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

IL-10Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis

Association of cytokine gene polymorphisms with susceptibility to cutaneous leishmaniasis in a Turkish population

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