Determination of the minimum fully protective dose of adenovirus-based DIVA vaccine against peste des petits ruminants virus challenge in East African goats

Holzer, Barbara; Taylor, Geraldine; Rajko-Nenow, Paulina; Hodgson, Sophia; Okoth, Edward; Herbert, Rebecca; Toye, Philip G.; Baron, Michael D.

doi:10.1186/s13567-016-0306-4

Cited by 20 publications

(24 citation statements)

References 20 publications

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“…However, DIVA vaccine candidates would need to be evaluated in comparison with conventional vaccines for the full range of vaccine attributes (e.g., efficacy, impact on virus shedding and transmission, duration of immunity, range of protection, safety, minimum dose, ease of production, cost) in addition to diagnostic advantages. Candidate vaccines for DIVA technologies include capripox (30,31) and adenovirusvectored vaccines (18,32). Prior exposure to capripox reduced the immune responses to the PPR Ags in vaccinates and, in the one study where challenge was carried out, incomplete protection against clinical disease.…”

Section: Suitable Vaccines and Diagnostics Are Availablementioning

confidence: 99%

The Opportunity To Eradicate Peste des Petits Ruminants

Mariner

Jones

Rich

et al. 2016

The Journal of Immunology

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Peste des petits ruminants (PPR) is a highly infectious disease of sheep and goats that is caused by PPR virus, a member of the genus Morbillivirus that includes the viruses that cause rinderpest (RP) in cattle. RP was the first animal disease to be globally eradicated in 2011 and is only the second disease, after smallpox, to have ever been eradicated. PPR is one of the principal constraints to small ruminant production in Africa, Asia, and the Middle East. The epidemiology of PPR and RP as well as the technologies available for their diagnosis and control are similar. The conditions that favored the eradication of RP are also largely present for PPR. In this work, we outline the evolving strategy for eradication in light of current opportunities and challenges, as well as the lessons from other eradication programs in animal and human health. The global PPR situation and technology for its control are summarized. A strategy based on the lessons from previous eradication efforts that integrate epidemiology, social science, and economics as tools to target and motivate vaccination is summarized. Major aspects of the cost and benefit-cost analysis of the indicated program are presented. The overall undiscounted cost of eradication was estimated as $3.1 billion, and the benefit-cost ratio for the most likely scenario was estimated at 33.8. We close with a discussion of the possible next steps.

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Section: Suitable Vaccines and Diagnostics Are Availablementioning

confidence: 99%

The Opportunity To Eradicate Peste des Petits Ruminants

Mariner

Jones

Rich

et al. 2016

The Journal of Immunology

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“…This is especially useful in situations where surveillance is being implemented at the same time as vaccination. In recent years several such vaccines have been successfully developed, particularly using adenovirus [52][53][54][55] and goat/ sheep pox vectors [56][57][58], and some have been tested for efficacy in conventional PPR challenge studies; however, their capacity for long-term protection (up to 2 years) has yet to be determined. For vectored vaccines, the presence of pre-existing immunity against the vector, i.e.…”

Section: Development and Application Of Pprv Vaccinesmentioning

confidence: 99%

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Baron

Diop

Njeumi

et al. 2017

Journal of General Virology

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Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia. Despite the availability of an efficacious and cheap live-attenuated vaccine, the virus has continued to spread, with its range stretching from Morocco in the west to China and Mongolia in the east. Some of the world's poorest communities rely on small ruminant farming for subsistence and the continued endemicity of PPRV is a constant threat to their livelihoods. Moreover, PPRV's effects on the world's population are felt broadly across many economic, agricultural and social situations. This far-reaching impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) to develop a global strategy for the eradication of this virus and its disease. PPRV is a morbillivirus and, given the experience of these organizations in eradicating the related rinderpest virus, the eradication of PPRV should be feasible. However, there are many critical areas where basic and applied virological research concerning PPRV is lacking. The purpose of this review is to highlight areas where new research could be performed in order to guide and facilitate the eradication programme. These areas include studies on disease transmission and epidemiology, the existence of wildlife reservoirs and the development of next-generation vaccines and diagnostics. With the support of the international virology community, the successful eradication of PPRV can be achieved.

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“…3C) albeit with an increased sensitivity. PPRV neutralising antibody titres in 72 serum samples from cattle vaccinated with live attenuated PPRV or RPV vaccines (as described in [31] and Fig. 1) were estimated using either VSV(PPRV Nigeria/75/1) on 293-dogSLAM cells or replication competent PPRV Nigeria/75/1 virus on Vero dogSLAM cells.…”

Section: Resultsmentioning

confidence: 99%

Enhanced immunosurveillance for animal morbilliviruses using vesicular stomatitis virus (VSV) pseudotypes

Logan

Dundon

Diallo

et al. 2016

Vaccine

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The measurement of virus-specific neutralising antibodies represents the “gold-standard” for diagnostic serology. For animal morbilliviruses, such as peste des petits ruminants (PPRV) or rinderpest virus (RPV), live virus-based neutralisation tests require high-level biocontainment to prevent the accidental escape of the infectious agents. In this study, we describe the adaptation of a replication-defective vesicular stomatitis virus (VSVΔG) based pseudotyping system for the measurement of neutralising antibodies against animal morbilliviruses. By expressing the haemagglutinin (H) and fusion (F) proteins of PPRV on VSVΔG pseudotypes bearing a luciferase marker gene, neutralising antibody titres could be measured rapidly and with high sensitivity. Serological responses against the four distinct lineages of PPRV could be measured simultaneously and cross-neutralising responses against other morbilliviruses compared. Using this approach, we observed that titres of neutralising antibodies induced by vaccination with live attenuated PPRV were lower than those induced by wild type virus infection and the level of cross-lineage neutralisation varied between vaccinates. By comparing neutralising responses from animals infected with either PPRV or RPV, we found that responses were highest against the homologous virus, indicating that retrospective analyses of serum samples could be used to confirm the nature of the original pathogen to which an animal had been exposed. Accordingly, when screening sera from domestic livestock and wild ruminants in Tanzania, we detected evidence of cross-species infection with PPRV, canine distemper virus (CDV) and a RPV-related bovine morbillivirus, suggesting that exposure to animal morbilliviruses may be more widespread than indicated previously using existing diagnostic techniques.

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Determination of the minimum fully protective dose of adenovirus-based DIVA vaccine against peste des petits ruminants virus challenge in East African goats

Cited by 20 publications

References 20 publications

The Opportunity To Eradicate Peste des Petits Ruminants

The Opportunity To Eradicate Peste des Petits Ruminants

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Enhanced immunosurveillance for animal morbilliviruses using vesicular stomatitis virus (VSV) pseudotypes

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