Determination of tiropramide in human plasma by liquid chromatography–tandem mass spectrometry

Lee, Hye Won; Ji, Hye Young; Kim, Hee Hyun; Cho, Hea-Young; Lee, Yong-Bok; Lee, Hye Suk

doi:10.1016/j.jchromb.2003.08.027

Cited by 11 publications

(7 citation statements)

References 3 publications

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“…In other words, the previously reported PK parameter values of tiropramide were similar to our PK results obtained by NCA analysis. After oral administration of 100 mg of tiropramide in humans, the obtained NCA PK parameters (as previously reported values) were 2.34-6.99 h for t 1/2 , 0.66-1.6 h for T max , 77.4-111 ng/mL for C max , and 267.7-812.7 h•ng/mL for AUC [6,12,[18][19][20][21]. On the other hand, the NCA PK parameters in this study were 3.41 ± 1.99 h for t 1/2 , 1.74 ± 0.63 h for T max , 69.07 ± 59.74 ng/mL for C max , and 280.34 ± 199.96 h•ng/mL for AUC, which were similar to the previously reported values.…”

Section: Discussionsupporting

confidence: 79%

“…Therefore, the covariate effect was confirmed by genotyping the OCT gene, which is known to be related to the absorption, distribution, and excretion of various organic cations [5]. Tiropramide is a substance derived from the amino acid tyrosine [6]. Therefore, the genotyping of the PEPT gene, which is known to be involved in the absorption and distribution of the peptide drugs such as peptides and β-lactam antibiotics, was performed to confirm the covariate effect [7].…”

Section: Introductionmentioning

confidence: 99%

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Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

et al. 2020

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The purpose of this study was to perform population pharmacokinetic (PPK) analysis of tiropramide in healthy Korean subjects, as well as to investigate the possible effects of various covariates on pharmacokinetic (PK) parameters of tiropramide. Although tiropramide is commonly used in digestive system-related diseases as an antispasmodic, PPK reporting and factors affecting PKs are not clearly reported. Thus, this study for healthy subjects is very significant because it could find new covariates in patients that had not been reported before or predict PPK for patients in the clinic by establishing PPK in healthy adults. By using Phoenix NLME, PK, demographic, and genetic data (collected to explain PK diversity of tiropramide in population) analyses were performed. As a basic model, a one-compartment with first-order absorption and lag-time was established and extended to include covariates that influenced the inter-subject variability. The total protein significantly influenced the distribution volume and systemic clearance of tiropramide, but genetic factors such as ABCB1 (1236C>T, 2677G>T/A, and 3435C>T), CYP2D6 (*1 and *10), OCT2 (808G>T), and PEPT1 (1287G>C) genes did not show any significant association with PK parameters of tiropramide. The final PPK model of tiropramide was validated, and suggested that some of the PK diversity in the population could be explained. Herein, we first describe the establishment of the PPK model of tiropramide for healthy Korean subjects, which may be useful as a dosing algorithm for the diseased population.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

et al. 2020

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“…Tiropramide is a water-soluble compound [2]. Hence, an attempt has been made to extract the drug from plasma by precipitating the plasma samples with solvents like acetonitrile, perchloric acid and methanol.…”

Section: Methods Developmentmentioning

confidence: 99%

“…Literature search revealed that very few pharmacokinetic studies are published and the reported methods are based on liquid chromatography-tandem mass spectrometry [2], gas chromatography/nitrogen phosphorus detector [3,4] semi-micro HPLC using column switching [5] and gas chromatography coupled to mass spectrometry [6]. Although the reported methods are sensitive and accurate but are expensive, and labor intensive.…”

Section: Introductionmentioning

confidence: 99%

A simple sample preparation with HPLC–UV method for estimation of tiropramide from plasma: Application to bioequivalence study

Khan

Loya

Natvarlal

2007

Journal of Pharmaceutical and Biomedical Analysis

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“…3 Several methods for the quantitative determination of tiropramide in biological fluids such as human plasma have been reported using gas chromatography (GC), 4,5 GC/mass spectrometry (GC/MS), 6 highperformance liquid chromatography (HPLC), 7 and LC/MS. 8 Tiropramide is marketed as a racemic mixture. The stereospecific activity of each enantiomer is not yet known.…”

mentioning

confidence: 99%

Enantioseparation of tiropramide by HPLC

Ryoo

Heo

Choi³

et al. 2004

Chirality

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Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.

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Determination of tiropramide in human plasma by liquid chromatography–tandem mass spectrometry

Cited by 11 publications

References 3 publications

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

A simple sample preparation with HPLC–UV method for estimation of tiropramide from plasma: Application to bioequivalence study

Enantioseparation of tiropramide by HPLC

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