Determination of tolterodine and its 5-hydroxymethyl metabolite in human plasma by hydrophilic interaction liquid chromatography–tandem mass spectrometry

Máček, Ján; Ptáček, Pavel; Klima, Josef

doi:10.1016/j.jchromb.2009.02.036

Cited by 29 publications

(22 citation statements)

References 6 publications

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“…Different interactions of chiral solutes with the helical structure of the MD emerge as the basis of the enantioselectivity. This notion is supported by 1 H and 13 C NMR experiments [27]. The helical structure of the MD mimics the cavity responsible for chiral recognition by CDs.…”

Section: Introductionmentioning

confidence: 71%

“…Common methods that have been used for routine analysis of TOL enantiomers were chromatographic and immunoassay techniques [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. In all these methods, the problem of sample pretreatment 8.…”

Section: Extraction From Biological Samplesmentioning

confidence: 99%

“…Determination of TOL has already been carried out using chromatographic methods such as gas chromatography-mass spectrometry (GC-MS) [7], capillary electrophoresis (CE) [8,9], high performance thin layer chromatography (HPTLC) [10,11] and high performance liquid chromatography (HPLC) with different detectors including tandem mass spectrometry (HPLC-MS-MS) [12][13][14][15], mass spectrometry (HPLC-MS) [16,17], and UV detection (HPLC-UV) [18][19][20][21][22]. But only a few published chromatographic methods are available for the determination of TOL enantiomers [8,9,18,19].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Electrically-enhanced microextraction combined with maltodextrin-modified capillary electrophoresis for quantification of tolterodine enantiomers in biological samples

Fakhari

Tabani

Behdad

et al. 2013

Microchemical Journal

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Section: Introductionmentioning

confidence: 71%

Section: Extraction From Biological Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrically-enhanced microextraction combined with maltodextrin-modified capillary electrophoresis for quantification of tolterodine enantiomers in biological samples

Fakhari

Tabani

Behdad

et al. 2013

Microchemical Journal

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“…These methods are developed by spectrophotometry, high performance liquid chromatography, gas chromatography-mass spectrometry, and capillary electrophoresis techniques (9)(10)(11)(12). The techniques require sophisticated instruments or rigorous sample preparation procedures.…”

Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric Method for the Determination of Tolterodine In Human Plasma and Pharmaceutical Preparations by Derivatization with Dansyl Chloride

Tekkeli¹

2017

Bezmialem Science

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Objective: Tolterodine (TOL) is an anti-muscarinic drug used for the symptomatic treatment of urinary incontinence. Analytical methods in the literature are not sensitive enough for the assay of drug substance biological fluids. To make up the deficit, we developed a sensitive, costreduced spectrofluorimetric method for the determination of TOL in plasma and pharmaceutical preparations.Methods: TOL has a phenolic hydroxyl group that reacts with dansyl chloride. The spectrofluorimetric method is based on this reaction in the presence of a bicarbonate solution of pH 9.5 to give a highly fluorescent derivative, which can be measured at 590 nm with an excitation wavelength at 360 nm in dichloromethane. Different experimental parameters affecting fluorescence intensity were optimized. The relationship between fluorescence intensity and TOL concentration was investigated. Results:The developed method is linear in the concentration range of 5-60 ng mL −1 with a minimum detectability of 0.136 ng mL −1 . The recovery was 100.48%. Conclusion:A simple, cost-effective, and sensitive spectrofluorimetric method was developed and validated for the determination of TOL in human plasma and pharmaceutical preparations using dansyl chloride. According to this validation study, it is possible to use this proposed method for the routine analysis of the drug and for conducting bioavailability and bioequivalence studies with good accuracy and precision.

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“…TLT has been studied and determined using a few analytical methods: HPLC -electrospray ionization mass spectrometric determination in human plasma [7], HPLC for the enantiometric separation of TLT [8], LC -tandem mass spectrometry in human plas ma [9], gas chromatography -mass spectrometry in plasma, serum, and urine [10], capillary solid phase extraction -tandem mass spectrometry in plasma samples [11], capillary liquid chromatography -tan dem mass spectrometry in plasma [12]. These reported methods require more expensive instrumentation and relatively high running costs.…”

mentioning

confidence: 99%

Sensitive and selective determination of tolterodine tartrate and its electrochemical investigation on solid carbon based electrodes

Kul

2014

J Anal Chem

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9701 Tolterodine tartrate (TLT) is a muscarinic receptor antagonist which is used for the treatment of urinary incontinence. It has a good selectivity for the muscar inic receptors for the overactive bladder. TLT helps preferably geriatric population to control urinary fre quency, urgency, and incontinence in detrusor insta bility. Tolterodine tartrate works on the lower urinary tract by increasing the residual urine and decreasing detrusor pressure [1,2].After oral administration, TLT is metabolised in the liver forming 5 hydroxymethyl derivative. This ac tive metabolite and tolterodine having similar anti muscarinic activity exhibit high specificity for musca rinic receptors, since they show clinically insignificant effects on other neurotransmitter receptors and other pharmacological targets such as calcium channels [3].TLT has fewer side effects than the other antimus carinic drugs such as oxybutynin, since it effectively targets the bladder and is tolerated better [4]. Thus, the patients need less drug and gain less side effects such as dizziness, abdominal pain, and headache [5,6]. The 1 The article is published in the original. chemical name of TLT with an empirical formula as C 26 H 37 NO 7 is (R) N,N diisopropyl 3 (2 hydroxy 5 methylphenyl) 3 phenylpropanamine L hydrogen tartrate (Structure I in Fig. 1).TLT has been studied and determined using a few analytical methods: HPLC -electrospray ionization mass spectrometric determination in human plasma [7], HPLC for the enantiometric separation of TLT [8], LC -tandem mass spectrometry in human plas ma [9], gas chromatography -mass spectrometry in plasma, serum, and urine [10], capillary solid phase extraction -tandem mass spectrometry in plasma samples [11], capillary liquid chromatography -tan dem mass spectrometry in plasma [12]. These reported methods require more expensive instrumentation and relatively high running costs. There has been no infor mation on the electrochemical behavior of TLT and its determination using any voltammetric techniques re ported in the literature. Electroanalytical methods of fer simple, sensitive, cheap, and fast measurements for the determination of a wide range of drug active com pounds. Moreover, it is important to investigate the electrochemical properties of the drugs, since meta Abstract-Tolterodine tartrate, a muscarinic receptor antagonist, was oxidized in various buffer media with different pH values using cyclic, differential pulse, and square wave voltammetric techniques on glassy carbon and boron doped diamond electrodes. Two irreversible anodic peaks were obtained. The oxidation process of tolterodine tartrate was diffusion controlled depending on pH for both electrodes. A detailed oxidation mech anism was proposed and discussed. The dependences of the peak current and peak potentials on pH, concen tration, nature of the buffer, and scan rate were investigated. A linear response between the peak current and the tolterodine tartrate concentration was obtained using differential pulse and square wave voltammetric te...

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Determination of tolterodine and its 5-hydroxymethyl metabolite in human plasma by hydrophilic interaction liquid chromatography–tandem mass spectrometry

Cited by 29 publications

References 6 publications

Electrically-enhanced microextraction combined with maltodextrin-modified capillary electrophoresis for quantification of tolterodine enantiomers in biological samples

Electrically-enhanced microextraction combined with maltodextrin-modified capillary electrophoresis for quantification of tolterodine enantiomers in biological samples

Spectrofluorimetric Method for the Determination of Tolterodine In Human Plasma and Pharmaceutical Preparations by Derivatization with Dansyl Chloride

Sensitive and selective determination of tolterodine tartrate and its electrochemical investigation on solid carbon based electrodes

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