Determination of total and individual kidney function in children by means of 123-I-hippuran whole body clearance and scintillation camera

Heidenreich, P.; Lauer, O; Fendel, H.; Oberdorfer, M.; Pabst, H. W.

doi:10.1007/bf00972039

Cited by 11 publications

(2 citation statements)

References 6 publications

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“…This method is widely used, particularly in Germany, and represents an accepted method for the clearance determination also in children (Heidenreich et al 1981).…”

Section: Methodsmentioning

confidence: 99%

A new principle to normalize plasma concentrations allowing single-sample clearance determinations in both children and adults

Bubeck

Piepenburg²,

Grethe

et al. 1992

Eur J Nucl Med

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A sufficiently accurate quantification of renal function requiring only one plasma sample without an additional gamma-camera study has, until now, only been possible in adults. A new principle will be presented here allowing the universal application of known algorithms, regardless of the clearance substance used, by normalizing the plasma concentrations with respect to the individual body dimensions of the patients--for infants as well as for adults. In this respect, algorithms are developed for clearance determinations using technetium-99m mercaptoacetyltriglycine (99mTc-MAG3), which are based on steady-state studies as the reference. They allow the calculation of quantitative clearance values in infants, requiring only one blood sampling at any time between the 25th and the 40th min postinjection. The comparison with a combined camera/two-plasma-sample technique performed in 46 children aged between 9 days and 14 years (mean 6.05 years) resulted in a standard error of 8.5% from the line of identity (r = 0.94). Moreover, this procedure also increases the accuracy of results in adults.

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“…This method is widely used, particularly in Germany, and represents an accepted method for the clearance determination also in children (Heidenreich et al 1981).…”

Section: Methodsmentioning

confidence: 99%

A new principle to normalize plasma concentrations allowing single-sample clearance determinations in both children and adults

Bubeck

Piepenburg²,

Grethe

et al. 1992

Eur J Nucl Med

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“…unterscheiden sich grundsätzlich darin, ob sie im Gleichgewichtszustand oder bei fallenden Aktivitätsspiegeln durchgeführt werden, und reichen von multiplen Blutentnahmen innerhalb von mehreren Stunden nach der Injektion bei GFR-Messungen (6) über die Messung der ausgeschiedenen Aktivität im Urin (9, 11) bis hin zur Uptake-Messung der Niere in den ersten Minuten nach Injektion (14,35) oder einer exakten Kompartiment-Analyse (10,30,40). Sie sind unterschiedlich gut geeignet für Notfallsituationen, kurzfristige Wiederholungen und Untersuchungen von Kindern (15,18,20). Im Erwachsenenalter wird die Messung meist mit der Oh-Methode in vielfältigen Abwandlungen durchgeführt (16,24,29,42), wobei die wichtigste Vereinfachung in der Bestimmung der Ganzkörperretentionskurve mit Hilfe einer repräsentativen Background-ROI besteht, die oberhalb der Nieren im Bereich von Leber, Milz und Herz gelegt wird (31,43).…”

Section: Clearancebestimmungenunclassified

Vergleich zweier Algorithmen zur Bestimmung der renalen Ganzkörper-Clearance nach simultaner Akquisition mit dem teilabgeschirmten Ganzkörperzähler und der Gammakamera

Kotzerke¹,

Wallburger²,

Gettner³

et al. 1990

Nuklearmedizin

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The influence of instrumentation, algorithm, and the time of blood sampling on whole-body renal clearance as defined by effective renal plasma flow (ERPF) was investigated. The study involved simultaneous sampling with a partially shielded whole-body counter (WBC) and a gamma camera to assess ERPF. The results obtained using two different analysis algorithms for each modality are compared. Although ERPF as determined by the Oberhausen technique was significantly higher than that obtained using an algorithm developed by the authors, for each algorithm there was no significant difference between the WBC and gamma camera-derived values within the range of 100 to 800 ml/ min. Furthermore, positioning of the ROI was not critical for gamma cameraderived ERPF (SD <1 % for multiple crescentic ROIs and approximately 4% for multiple rectangular ROIs). However, the time of blood sampling did appear more important since the average ERPF derived from the 10- and 20-min samples compared with that from the 15- and 25-min samples differed significantly for both analysis algorithms. The methodology which we have validated provides a more precise tool for further investigations of the influence of medication, posture, and exercise stress on renal function.

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Kidneys

Treves¹,

Harmon²,

Packard³

et al.

Pediatric Nuclear Medicine/Pet

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Determination of total and individual kidney function in children by means of 123-I-hippuran whole body clearance and scintillation camera

Cited by 11 publications

References 6 publications

A new principle to normalize plasma concentrations allowing single-sample clearance determinations in both children and adults

A new principle to normalize plasma concentrations allowing single-sample clearance determinations in both children and adults

Vergleich zweier Algorithmen zur Bestimmung der renalen Ganzkörper-Clearance nach simultaner Akquisition mit dem teilabgeschirmten Ganzkörperzähler und der Gammakamera

Kidneys

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