Determination of Venlafaxine and Modafinil in Individual Tablet Dosage Forms using Single RP-HPLC Method

Younus, Mohammad; Arif, Fasiuddin; Richards, Mark; Kumar, D B Aruna

doi:10.4314/tjpr.v12i2.17

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Various analytical methods were reported for estimation of MOD as HPLC [1][2][3][4][5][6], UPLC [7], HPTLC [8], fluorimetric [9], spectrophotometry [10,11] and capillary electrophoresis [12].…”

Section: Introductionmentioning

confidence: 99%

Rapid One-Pot Microwave Assisted Green Synthesis Nitrogen Doped Carbon Quantum Dots as Fluorescent Precursor for Estimation of Modafinil as Post-Covid Neurological Drug in Human Plasma with Greenness Assessments

Salman

Hassan

et al. 2022

J Fluoresc

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The neuro-stimulant anti-narcoleptic drug as modafinil (MOD) is used to treatment neurological conditions caused by COVID-19. MOD was used to treatment narcolepsy, shift-work sleep disorder, and obstructive sleep apnea-related sleepiness. So, an innovative, quick, economical, selective, and ecologically friendly procedure was carried out. A highly sensitive N@CQDs technique was created from green Eruca sativa leaves in about 4 min using microwave synthesis at 700 w. The quantum yield of the synthesized N@CQDs was found to be 41.39%. By increasing the concentration of MOD, the quantum dots' fluorescence intensity was gradually quenched. After being excited at 445 nm, the fluorescence reading was recorded at 515 nm. The linear range was found to be in the range 50 – 700 ng mL−1 with lower limit of quantitation (LOQ) equal to 45.00 ng mL−1. The current method was fully validated and bio analytically according to (US-FDA and ICH) guidelines. Full characterization of the N@CQDs has been conducted by high resolution transmission electron microscope (HRTEM), Zeta potential measurement, fluorescence, UV–VIS, and FTIR spectroscopy. Various experimental variables including pH, QDs concentration and the reaction time were optimized. The proposed study is simply implemented for the therapeutic drug monitoring system (TDMS) and various clinical laboratories for further pharmacokinetic research.

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Section: Introductionmentioning

confidence: 99%

Rapid One-Pot Microwave Assisted Green Synthesis Nitrogen Doped Carbon Quantum Dots as Fluorescent Precursor for Estimation of Modafinil as Post-Covid Neurological Drug in Human Plasma with Greenness Assessments

Salman

Hassan

et al. 2022

J Fluoresc

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“…Various analytical methods have been reported to estimate MDF individually and in concomitant with other drug in fluids or pharmaceutical dosage form using direct spectrophotometric method (Zero order) at 252 nm, first order derivative method at 234 nm [6], Direct Open Access spectrophotometric method at 260 nm [7], Colorimetric method using methyl orange at 525 nm and methylene blue at 664 nm [8], Colorimetric method utilizing 2,4-dinitrophenol and 1,2-naphthoquinone-4-sulphonate at wavelengths of 475 nm and 430 nm respectively [9], RP-HPLC [10,11], capillary electrophoresis [12] and LC/ MS [13] but few of them have been developed to estimate MDF in the presence of its degradation products using HPLC [14,15], HPTLC [16] and capillary zone electrophoresis [17].…”

Section: Introductionmentioning

confidence: 99%

Smart stability indicating spectrophotometric methods for determination of modafinil: the promising treatment for post-covid neurological syndrome

et al. 2022

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Modafinil (MDF) is one of the neurostimulants with a potential effect in the COVID-19 ICU ventilated patients and post-COVID neurological syndrome treatment. Four rapid, simple and cost-effective stability indicating spectrophotometric methods were used for estimation of MDF in the presence of its acidic degradation product, namely; ratio difference (RD), first derivative of the ratio spectra (1DD), mean centering (MCR) and ratio subtraction method (RS). These methods were validated according to ICH guidelines and all methods revealed a good linearity in concentration range of (5-30 µg/mL) in addition to a good accuracy and precision with mean percentage recovery of 99.97 ± 0.305 for (RD), 100.10 ± 0.560 for (1DD), 100.02 ± 0.483 for (MCR) & 99.18 ± 1.145 for (RS) method. Specificity of the proposed methods was assessed and MDF was determined in the presence of up to 80% of its acidic degradation product for RD, 1DD, MCR and RS methods. The proposed methods were successfully applied for the determination of MDF in bulk powder and its tablet dosage form with mean percentage recovery of 100.33 ± 0.915 for (RD), 100.62 ± 0.985 for (1DD), 99.70 ± 0.379 for (MCR) and 100.21 ± 0.313 for (RS) method. The results obtained were statistically compared with those of official HPLC method and showed no significant difference with relevance accuracy and precision.

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A Review on Analytical Method for Determination of Venlafaxine HCl in Bulk and Pharmaceutical dosage form

Dighe

Siddheshwar

Shinde

2021

RJST

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Venlafaxine HCl is one of the antidepressant agent which comes under the category of serotonin-norepinephrine reuptake inhibitor i.e SNRI. This medication is usually used to treat major depressive disorder in adult. It may help to improve the mood and energy level and also to regain the interest in daily activities in the depressed person. The present review focus on various approaches for the analysis on Venlafaxine in bulk and pharmaceutical dosage forms. The review represents the various analytical method like the RP-HPLC, HPTLC, UV Spectroscopy and Stability Indicating Methods which were used for the investigation of Venlafaxine in bulk and different dosage formulations.

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Determination of Venlafaxine and Modafinil in Individual Tablet Dosage Forms using Single RP-HPLC Method

Cited by 4 publications

References 12 publications

Rapid One-Pot Microwave Assisted Green Synthesis Nitrogen Doped Carbon Quantum Dots as Fluorescent Precursor for Estimation of Modafinil as Post-Covid Neurological Drug in Human Plasma with Greenness Assessments

Rapid One-Pot Microwave Assisted Green Synthesis Nitrogen Doped Carbon Quantum Dots as Fluorescent Precursor for Estimation of Modafinil as Post-Covid Neurological Drug in Human Plasma with Greenness Assessments

Smart stability indicating spectrophotometric methods for determination of modafinil: the promising treatment for post-covid neurological syndrome

A Review on Analytical Method for Determination of Venlafaxine HCl in Bulk and Pharmaceutical dosage form

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