Determination of Ziprasidone by UPLC-MS-MS and Its Application to a Pharmacokinetic Study of Chinese Schizophrenics

Lei, Yanqing; Zhang, Wenyuan; Huan-de, LI; Yan, Miao; Zhu, Rong

doi:10.1365/s10337-010-1725-4

Cited by 10 publications

(17 citation statements)

References 15 publications

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“…HPLC-MS, especially HPLC-MS/MS, has been proven to be a powerful technique for the analysis of drugs and pesticides at trace concentration levels owing to its high selectivity, precision, and sensitivity [10][11][12]. Among several ionization modes, ESI has been proven to be reliable, robust, and sensitive [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Determination of Chlorantraniliprole Residues in Corn and Soil by UPLC–ESI–MS/MS and Its Application to a Pharmacokinetic Study

Dong

Liu

et al. 2011

Chromatographia

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A rapid, highly sensitive, and selective method was developed for the determination of the insecticide chlorantraniliprole (CAP) in corn and soil using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Samples were extracted with acetonitrile, and aliquots were cleaned with solid-phase extraction cartridges. Two precursor-product ion transitions for CAP were measured and evaluated to provide maximum confidence in the results. Average recovery for soil, corn grain, and corn straw at different levels (5 or 10, 40, and 100 lg kg -1 ) ranged from 74.9 to 97.5%, with intra-day relative standard deviation (RSD) values of 1.9-11.3% and inter-day RSD values of 4.7-10.4%. Coefficients of determination (R 2 ) of 0.9988 or higher were achieved for CAP in soil, corn grain, and corn straw matrix calibration curves, from 5 to 1,000 lg L -1 . The CAP limits of quantitation in soil, corn grain, and straw were determined to be 5, 10, and 10 lg kg -1 , respectively, which were much lower than the maximum residue levels established by the Environmental Protection Agency of United States. UPLC-MS/MS was used to determine the CAP residues in real corn and soil for studies on their dissipation. The trial results showed that the half-lives of CAP changed from 12.6 to 23.1 days in soils and ranged from 4.9 to 5.4 days in corn straws in the districts of Henan and Shandong, and the average levels of CAP residues in corn grains were all \0.01 mg kg -1 with a harvest withholding period of 180 days.

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Section: Introductionmentioning

confidence: 99%

Determination of Chlorantraniliprole Residues in Corn and Soil by UPLC–ESI–MS/MS and Its Application to a Pharmacokinetic Study

Dong

Liu

et al. 2011

Chromatographia

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“…Generally, because of the unpredictable therapeutic effects, empiricism still plays a dominant role during the clinical use of antipsychotics. Moreover, owing to significant individual differences, the same dose could produce quite different clinical responses in different patients (Lei, Zhang, Li, Yan, & Zhu, ). To compensate for such variation and realize rational medication, therapeutic drug monitoring (TDM) is required.…”

Section: Introductionmentioning

confidence: 99%

Development of a UPLC‐MS/MS method for routine therapeutic drug monitoring of aripiprazole, amisulpride, olanzapine, paliperidone and ziprasidone with a discussion of their therapeutic reference ranges for Chinese patients

Wang

2017

Biomedical Chromatography

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A highly feasible and reliable ultra-high performance liquid chromatography tandem mass spectrometry method was presented for therapeutic drug monitoring of five anti-schizophrenic drugs (amisulpride, olanzapine, aripiprazole, paliperidone and ziprasidone) simultaneously. To meet the requirements of practical clinical usage (easy handling, high throughput and cost effectiveness), the pretreatment process was simplified (only including protein precipitation and mobile phase dilution steps) and the UPLC separation cycle was set within 6 min. The whole methodology was carefully validated according to the latest international guidelines showing the excellent selectivity, accuracy, precision, applicability and stability. After a 10 month clinical application, a retrospective analysis of 253 positive samples was carried out to investigate conformance with the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie therapeutic reference range for Chinese patients. The results suggested good consistency for olanzapine, aripiprazole, paliperidone and ziprasidone, while for amisulpride, the plasma concentration level (445.2 ± 231.5 ng/mL) was relatively higher than the recommended range (100-320 ng/mL). We supposed that such phenomenon indicated the necessity of reconstructing a Chinese-specific therapeutic reference range for amisulpride treatment, which would be helpful to improve medication efficiency and safety for Chinese patients.

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“…Since many pesticides are characterized by relatively low application rates, the concentrations of these pesticides found in the environment are usually trace levels. In order to simplify the process of sample preparation and reduce the loss of analytes, LC-MS/MS was used in this study owing to its high selectivity, accuracy, precision and sensitivity (Laganà et al, 2000;Lee et al, 2009;Lei et al, 2010). The aim of the present study was to establish a modified QuEChERS sample preparation method using LC-MS/MS for detection of RH-5849 and indoxacarb in soil, rice straw, rice husk and brown rice.…”

Section: Introductionmentioning

confidence: 99%

Determination of RH‐5849 and indoxacarb in rice straw, rice husk, brown rice and soil using liquid chromatography–tandem triple quadrupole mass spectrometry following extraction with QuEChERS method

Zhao

Chen

et al. 2016

Biomedical Chromatography

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A fast and simple analytical method was developed for the simultaneous determination of RH-5849 and indoxacarb in soil, rice straw, rice husk and brown rice. QuEChERS (quick, easy, cheap, effective, rugged and safe) method was used for extraction, and liquid chromatography with tandem triple quadrupole mass spectrometry was used for quantification. The matrix-matched calibration plots were linear in the range between 25 and 5000 μg/L for soil, rice straw, rice husk and brown rice samples. All determination coefficients (R 2 ) were ≥0.9962. The limits of detection and quantification were 1.5 and 5 μg/kg, respectively. Recoveries at three fortification levels ranged between 79.5 and 97.9% with relative standard deviations <11%. The developed method was validated and applied for the analysis of dissipation study samples. For field experiments, the half-lives of RH-5849 and indoxacarb in rice straw were 11.93 and 5.83 days, respectively. The method was demonstrated to be reliable for the routine monitoring of RH-5849 and indoxacarb in rice samples.

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Determination of Ziprasidone by UPLC-MS-MS and Its Application to a Pharmacokinetic Study of Chinese Schizophrenics

Cited by 10 publications

References 15 publications

Determination of Chlorantraniliprole Residues in Corn and Soil by UPLC–ESI–MS/MS and Its Application to a Pharmacokinetic Study

Determination of Chlorantraniliprole Residues in Corn and Soil by UPLC–ESI–MS/MS and Its Application to a Pharmacokinetic Study

Development of a UPLC‐MS/MS method for routine therapeutic drug monitoring of aripiprazole, amisulpride, olanzapine, paliperidone and ziprasidone with a discussion of their therapeutic reference ranges for Chinese patients

Determination of RH‐5849 and indoxacarb in rice straw, rice husk, brown rice and soil using liquid chromatography–tandem triple quadrupole mass spectrometry following extraction with QuEChERS method

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