Detrimental Effects of Maternal Lead Exposure during Pregnancy and Lactation on Molar Development in the Young Rat

Chen, Hong-Sen; Tsai, Yu-Chen; Chen, Ker-Kong; Tseng, Yu-Chuan; Hsu, Kun-Jung

doi:10.1007/s00128-012-0683-y

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…Each of these environmental insults has been suggested as a cause of dental developmental defects in animals and human populations [19,20] and has been identified as present in Poundbury [2]. Rather than having individual effects, they may have acted in summative or even synergistic ways to constitute major environmental stress throughout dental development in the Romano-British population.…”

Section: Resultsmentioning

confidence: 99%

Influences in a biologically complex adaptive system: Environmental stress affects dental development in a group of Romano-Britons

Brook¹,

Koh²,

Toh³

2015

Int. J. DNE

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The human dentition shows the general characteristics of a complex adaptive system. Interactions at a molecular level of genetic, epigenetic and environmental factors lead to the emergence of tooth germs. Subsequently differentiated specialised cells control mineralisation and then mature teeth emerge, showing marked variation. The mature dentition provides a record of developmental influences from its initiation at 6 weeks in utero to its completion at 20 years of age. It is, therefore, a valuable paradigm of general development.The substantial collection of skeletal material of 200-400 AD Romano-Britons from Poundbury, Dorset, has been extensively studied, providing much evidence concerning lifestyle and medical conditions. In this study, we investigate further findings concerning dental development. The aims are to compare the findings with those for Modern Britons and to identify the effects of major factors known to affect the Romano-Britons in order to consider the possible synergism of these effects. The findings were that the patterning of the dentition, its sexual dimorphism and the types of developmental defects were similar to modern Britons. However, the RomanoBritons had more anomalies, generally smaller tooth crowns and roots, and more severe enamel defects. Thus, the Romano-Britons' dentition showed evidence of insults occurring at all stages of tooth development. These effects, occurring over a long period of time and affecting tissues with different genetic backgrounds, probably arise from ongoing major environmental insults known to be present in Poundbury. These insults have been identified as excess lead ingestion, poor nutrition and recurrent infections. We propose that these factors, acting synergistically, constituted marked environmental stress affecting development.

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Section: Resultsmentioning

confidence: 99%

Influences in a biologically complex adaptive system: Environmental stress affects dental development in a group of Romano-Britons

Brook¹,

Koh²,

Toh³

2015

Int. J. DNE

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A metabolomic study on the association of exposure to heavy metals in the first trimester with primary tooth eruption

Guan

et al. 2020

Science of The Total Environment

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Alterations in odontogenesis and tooth eruption resulting from exposure to hexavalent chromium in suckling animals

Sánchez

Ubios

2019

Int J Paed Dentistry

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BackgroundHeavy metals including Cr VI are present in inadequately treated effluents that contaminate drinking water. Hence, Cr VI exposure can affect children through intake of breast milk from an exposed mother or bottle‐feeding formula prepared with contaminated water. To date, there are no reports on the effects of Cr VI exposure on tooth formation processes concomitant to tooth eruption.AimTo study the effect of Cr VI exposure on tooth tissue formation in suckling Wistar rats by assessing dental tissues at different stages of tooth eruption.DesignExperimental animals received 12.5 mg/kg body weight/day of a potassium dichromate solution by gavage; control animals were similarly administered an equivalent volume of saline solution. Each group was divided into three subsets according to age at euthanasia: 9, 15, and 23 days. Dental formation was analysed histologically and histomorphometrically. Statistical analysis: Student's t test; P < .05.ResultsCr VI‐exposed animals showed a delay in mineralized crown and root tissue formation. These findings are directly associated with the observed delay in tooth eruption.ConclusionOur findings show the importance of monitoring drinking water levels of toxic substances, since exposure during early childhood can alter tooth formation, growth, and development.

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Detrimental Effects of Maternal Lead Exposure during Pregnancy and Lactation on Molar Development in the Young Rat

Cited by 3 publications

References 20 publications

Influences in a biologically complex adaptive system: Environmental stress affects dental development in a group of Romano-Britons

Influences in a biologically complex adaptive system: Environmental stress affects dental development in a group of Romano-Britons

A metabolomic study on the association of exposure to heavy metals in the first trimester with primary tooth eruption

Alterations in odontogenesis and tooth eruption resulting from exposure to hexavalent chromium in suckling animals

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