Development and characterization of a new hydrogel based on galactomannan and κ-carrageenan

Abstract

A new hydrogel based on two natural polysaccharides was prepared in aqueous medium with 1.7% (w/v) galactomannan (from Cassia grandis seeds) and different concentrations of κ-carrageenan (0.3, 0.4 and 0.5%w/v), CaCl2 (0.0, 0.1 and 0.2M) and pH (5.0, 5.5 and 6.0), using a full factorial design based on rheological parameters. The best formulation was obtained with 1.7% (w/v) galactomannan and 0.5% (w/v) κ-carrageenan, containing 0.2M CaCl2 at pH 5.0. Nuclear magnetic resonance and scanning electron microscopy where used in order to characterize the hydrogel formulation. A shelf life study was carried out with this formulation along 90 days-period of storage at 4 °C, evaluating pH, color, microbial contamination and rheology. This hydrogel showed no significant changes in pH, no microbial contamination and became more translucent along the aging. Analyses by nuclear magnetic resonance and rheology showed a larger organization of the polysaccharides in the hydrogel matrix. The results demonstrated that this hydrogel was stable with possible applications in medical and cosmetic fields.

Investigating a galactomannan gel obtained from Cassia grandis seeds as immobilizing matrix for Cramoll lectin

“…Our results are in agreement with Soares et al [6]. who developed a new hydrogel based upon optimized rheological characteristic of a mixture of -carrageenan and the galactomannan extracted from C. grandis seeds at the same concentration as that from our work.…”

“…The classical gel behavior (G parallel to G as a function of frequency) was observed by Soares et al [6] for the hydrogel composed by -carrageenan and the pure galactomannan gel. The pure galactomannan hydrogel was rheologicaly tested during 90 days period and a stiffening process was observed where both G and G increase as a function of storage.…”

“…Galactomannans are used in food, pharmaceutical, biomedical, cosmetic, textile and paper industries. Many studies have reported the potential use of galactomannans as thickeners [5], part of mixed systems such as hydrogels [6], emulsion stabilizers in the preparation of films [7] and edible films themselves with enhanced barrier as well as mechanical properties that extend and improve food shelf-life [8,9]. It is also important to highlight the application of galactomannans in the cosmetic industry [10] and as matrix for immobilization of certain biomolecules [11][12][13][14].…”

Rational Hydrogel Formulation Leads to Reversible and Enhanced Photocontrolled Rigidity

“…Furthermore, DOE makes it possible to study the combined effects between independent variables and nonlinear relations in the responses, thus predicting the optimal conditions more accurately than OVAT.D OE has already been successfully applied to adjust hydrogel compositioni nt erms of drug delivery kinetics, [18] water uptake capacity, [19] or mechanical stability. [20] Doehlert design is at ype of DOE methodology that was chosen in this paper because of its remarkable efficiency. [21] E values and UV/Vis absorbance at l = 365 nm were the studied responses as af unction of gelator concentration (total monomer concentration)a nd of the degree of covalent crosslinking (relation between four-armed thiol-terminated PEG and total added PEG) for b-CD com and b-CD syn hydrogels.…”

INCORPORATION VITAMIN E FROM PFAD IN MATRIX OF MIXED GALAKTOMANAN KOLANG-KALING (Arenga pinnata) AND GUM ACASIA

“…Akan tetapi penggunaan gum acasia dinilai mahal dan persediaan terbatas. Soares et al, menyatakan dalam penelitiannya bahawa campuran hidrogel yang baik dan stabil secara fisik akan lebih memungkinkan digunakan pada industri kosmetik dan obat-obatan [11].…”