Abstract:Despite its high structural strength and degradability, the potentiality of pure iron foam for bone scaffolds is low due to its lack of surface bioactivity. This work aims to provide a surface bioactivity to the iron foam by developing a calcium phosphate (CaP) conversion coating. Silver (Ag), known for its antibacterial property, was then incorporated onto the CaP coating via co-deposition (Ag/CaP-c) and post-treatment (Ag/CaP-p). By tuning the Ca/P ion ratio and Ag concentration during the coating process, a… Show more
“…The high surface area would accelerate the in vivo degradation when an appropriate porosity was applied. In addition to the porous structure design, the surface modification is preferred with superior controllability to modulate the degradation rate [ 155 , 156 ]. Moreover, the CaP coating could possibly change the degradation mechanism to reduce the harmful iron phosphate-based components [ 155 , 156 ].…”
Section: Surface Biofunctions With Calcium Phosphate Coatingsmentioning
confidence: 99%
“…It could be seen that the pure HA coating could reduce the growth of Staphylococcus aureus and Porphyromonas gingivalis compared to the Ti surface, while the fluorine incorporation in the HA coating further enhanced the antibacterial performance when cultured all the three bacteria. In addition to fluorine, silver, copper, and Zn are also well-known for their antibacterial performance and have been incorporated in the CaP phase to obtain antibacterial CaP coatings [ 156 , 169 , 170 ]. Fig.…”
Section: Surface Biofunctions With Calcium Phosphate Coatingsmentioning
Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability. Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions. Calcium phosphates (CaPs) are the major inorganic component of bone tissues, and thus owning inherent biocompatibility and osseointegration properties. As such, they have been widely used in clinical orthopedics and dentistry. The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs. This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings. We first glance over different types of CaPs with their coating methods and
in vitro
and
in vivo
performances, and then give insight into the representative biofunctions, i.e. osteointegration, corrosion resistance and biodegradation control, and antibacterial property, provided by CaP coatings for metallic implant materials.
“…The high surface area would accelerate the in vivo degradation when an appropriate porosity was applied. In addition to the porous structure design, the surface modification is preferred with superior controllability to modulate the degradation rate [ 155 , 156 ]. Moreover, the CaP coating could possibly change the degradation mechanism to reduce the harmful iron phosphate-based components [ 155 , 156 ].…”
Section: Surface Biofunctions With Calcium Phosphate Coatingsmentioning
confidence: 99%
“…It could be seen that the pure HA coating could reduce the growth of Staphylococcus aureus and Porphyromonas gingivalis compared to the Ti surface, while the fluorine incorporation in the HA coating further enhanced the antibacterial performance when cultured all the three bacteria. In addition to fluorine, silver, copper, and Zn are also well-known for their antibacterial performance and have been incorporated in the CaP phase to obtain antibacterial CaP coatings [ 156 , 169 , 170 ]. Fig.…”
Section: Surface Biofunctions With Calcium Phosphate Coatingsmentioning
Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability. Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions. Calcium phosphates (CaPs) are the major inorganic component of bone tissues, and thus owning inherent biocompatibility and osseointegration properties. As such, they have been widely used in clinical orthopedics and dentistry. The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs. This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings. We first glance over different types of CaPs with their coating methods and
in vitro
and
in vivo
performances, and then give insight into the representative biofunctions, i.e. osteointegration, corrosion resistance and biodegradation control, and antibacterial property, provided by CaP coatings for metallic implant materials.
“…Recently, network-like metal foams [ 6 , 17 , 22 , 23 ], including open-cell iron foams [ 9 , 11 , 18 ], have been identified as promising materials for hard tissue scaffolds as they exhibit a natural bone-like structure, which supports the vascularization, growth, and proliferation of bone cells and reduces corrosion resistance [ 6 , 17 , 18 , 22 , 24 ]. The improvement of the mechanical strength of iron foams can be achieved by the addition of low amounts of phosphorus without retarding the corrosion rate or affecting the cell proliferation [ 11 , 14 ].…”
Advances in biomedicine and development of modern technologies in the last century have fostered the improvement in human longevity and well-being. This progress simultaneously initiated the need for novel biomaterials. Recently, degradable metallic biomaterials have attracted serious attention in scientific and clinical research owing to their utilization in some specific applications. This work investigates the effect of the polyethylene glycol (PEG) coating of open-cell iron and phosphorus/iron foams on their microstructure and corrosion properties. The addition of phosphorus causes a slight increase in pore size and the deposition of a polymer coating results in a smoothened surface and a moderate decrease in pore diameter. The PEG coating leads to an increase in corrosion rates in both foams and potentially a more desirable product.
“…Silver-containing tricalcium phosphate microspheres composed of α/βTCP phases were synthesized using an ultrasonic spray-pyrolysis technique [ 4 ]. Su et al [ 5 ] studied silver containing calcium phosphate coatings on pure iron foam obtained via co-deposition and post-treatment method. Siek et al [ 6 ] used wet chemical method to obtain bactericidal αTCP-based bone cements with silver-modified hydroxyapatite (Ag-HA) and CaCO 3 .…”
Implantations in orthopedics are associated with a high risk of bacterial infections in the surgery area. Therefore, biomaterials containing antibacterial agents, such as antibiotics, bactericidal ions or nanoparticles have been intensively investigated. In this work, silver decorated β tricalcium phosphate (βTCP)-based porous scaffolds were obtained and coated with a biopolymer—poly(3-hydroxybutyrate)-P(3HB). To the best of our knowledge, studies using silver-doped βTCP and P(3HB), as a component in ceramic-polymer scaffolds for bone tissue regeneration, have not yet been reported. Obtained materials were investigated by high-temperature X-ray diffraction, X-ray fluorescence, scanning electron microscopy with energy dispersive spectroscopy, hydrostatic weighing, compression tests and ultrahigh-pressure liquid chromatography with mass spectrometry (UHPLC-MS) measurements. The influence of sintering temperature (1150, 1200 °C) on the scaffolds’ physicochemical properties (phase and chemical composition, microstructure, porosity, compressive strength) was evaluated. Materials covered with P(3HB) possessed higher compressive strength (3.8 ± 0.6 MPa) and surgical maneuverability, sufficient to withstand the implantation procedures. Furthermore, during the hydrolytic degradation of the composite material not only pure (R)-3-hydroxybutyric acid but also its oligomers were released which may nourish surrounding tissues. Thus, obtained scaffolds were found to be promising bone substitutes for use in non-load bearing applications
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