Development and Evaluation of Ion Induced in Situ Gelling System of Opoid Analgesic for Nose to Brain Delivery

Mahajan, Nilesh; Shende, Shital; Dumore, Nitin G.; Nasare, Latika

doi:10.5958/0974-360x.2019.00817.5

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The polymer absorbs water and forms a gel barrier on the outer surface, gradually releasing the drug from the swollen matrix. 6,7,12,17 Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), possesses analgesic and antipyretic properties.…”

Section: Formulation and Evaluation Of Gastroretentivementioning

confidence: 99%

“…This formulation represents an innovative and promising approach to drug delivery, offering potential benefits such as improved gastric retention, controlled drug release, and enhanced bioavailability. 6,7 By synthesizing a ketoprofen raft-forming system as an in situ gel, we aim to extend the drug's residence period and delivery time, thus addressing issues such as repeated oral dosing, noncompliance, and drug toxicity. Overall, developing ketoprofen in situ gel aims to enhance the drug's therapeutic performance, providing a novel and promising solution for improved drug delivery.…”

Section: Formulation and Evaluation Of Gastroretentivementioning

confidence: 99%

See 1 more Smart Citation

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Shabaraya,

T Ashwini,

Vineetha

2023

European Pharmaceutical Journal

View full text Add to dashboard Cite

A revolutionary concept for achieving long-term medication release is the gastroretentive in situ gelling system. The goal of this research was to formulate and test a gastroretentive in situ gel for ketoprofen delivery to targeted site to increase the residence and delivery time. Ketoprofen gastroretentive in situ gels were synthesized using a cation-driven gelation approach using various combinations and concentrations of polymers such as gellan gum, sodium alginate, and hydroxypropyl methylcellulose (HPMC) K100M. Visual appearance, pH, viscosity, in vitro gelation, in vitro buoyancy, drug content, density measurement, gel strength measurement, water uptake, and in vitro drug release were all evaluated. The total floating time was more than 12 h, with a floating lag time of less than 2 min. The formulations showed pH ranging from 6.89 to 7.61 and drug content ranging from 82.01% to 95.53%. For 11 h, the percent cumulative drug release of formulations F5 and F14, which contained a greater concentration of polymer sodium alginate (1.5%) and a combination of gellan gum and HPMC K100M (0.175% and 0.2%), was 84.10% and 85.49%, respectively. In vitro dissolution experiments and stability investigations both revealed no significant changes in drug content. The findings revealed that the formulated in situ gels aided in extending gastric residence duration, allowing the drug to be released in the stomach.

show abstract

Section: Formulation and Evaluation Of Gastroretentivementioning

confidence: 99%

Section: Formulation and Evaluation Of Gastroretentivementioning

confidence: 99%

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Shabaraya,

T Ashwini,

Vineetha

2023

European Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review

Mohammad Hamdi,

Azmi,

Mohd Sabari

et al. 2023

JoP

View full text Add to dashboard Cite

Introduction: In recent years, mucoadhesive topical application of mucous membrane has gained considerable interest among formulation researchers in advanced drug delivery systems. It has been identified as a potential route for both local and systemic drug delivery. A mucoadhesive agent is usually incorporated in the formulation to overcome the disadvantages associated with the conventional topical formulation. These disadvantages include low residence time of the medication on the site of application due to tongue movement and salivary washout in the intraoral formulation, mucociliary clearance in the intranasal application, and rapid precorneal elimination in the intraocular formulation. Carbomer or known as Carbopol is a mucoadhesive polymer that is widely studied for topical delivery of pharmaceutical agents to the mucous membrane. The use of Carbopol and its advantages in the mucoadhesive topical application has gained considerable interest with several published studies and is available in various grades. In this study, a systematic review was performed on the available literature that investigates the Carbopol application in mucoadhesive topical drug delivery. Method: A systematic searching strategy was performed in Scopus, ProQuest, and PubMed databases using predetermined search strings. A total of 778 articles were retrieved, however, only 25 articles met the inclusion criteria and were used for data synthesis. Results: The results showed that incorporation of Carbopol as mucoadhesive polymer hold multiple advantages in drug delivery namely excellent mucoadhesion effect, the prolonged residence time of the formulation, enhanced drug permeation, prolonged release of drug, pseudoplastic behaviour of the formulation, pH compatibility with all mucosal site, and biocompatible. Conclusion: This suggests that the incorporation of Carbopol can be an effective mucoadhesive agent for topical drug delivery systems.

show abstract

Development and Evaluation of Thermo Triggered in situ Nasal Gel of Selegiline for Depressive Disorders: In vitro, in vivo and ex vivo Characterization

Srivastava¹,

Prasad²,

Jha³

2022

RJPT

View full text Add to dashboard Cite

In present scenario selective serotonin reuptake inhibitors are the first-choice drug for depression, but as per study of American Psychiatric Association monoamine oxidase inhibitor may be used as an antidepressant when other antidepressant trial on patient have been failed. Selegiline is both MAO-A and MOA-B inhibitor (dose dependent). Present delivery system is an in situ gelling system based on the chitosan and β-glycrophosphate. β-Glycerophosphate is used in form of di sodium salt which is a weakly basic compound which is naturally found in the body. In situ gelling system was prepared by addition of β- glycerophosphate to chitosan polymer causes conversion of pH sensitive chitosan to temperature sensitive. Developed formulations were evaluated for mucoadhesive strength, gel strength, drug content, in vitro release which was found 17.0±1.0 seconds, 6.4±0.1, 229.3±1.0 cp, 1433.3±1.2 cp, 99.45±0.4 %, 35.7±0.6 seconds, 3035.78±0.46 dyne/cm2 respectively. Histopathological studies of treated nasal mucosa of sheep revealed that selected formulation batch have no toxic effect on mucosal layer and no significant change was observed in mucosal structure. In vivo study of prepared optimized in situ gel was found more efficacious compare to marketed oral tablet of selegiline.

show abstract

Development and Evaluation of Ion Induced in Situ Gelling System of Opoid Analgesic for Nose to Brain Delivery

Cited by 4 publications

References 0 publications

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

An insight into the use and advantages of Carbopol in topical mucoadhesive drug delivery system: A systematic review

Development and Evaluation of Thermo Triggered in situ Nasal Gel of Selegiline for Depressive Disorders: In vitro, in vivo and ex vivo Characterization

Contact Info

Product

Resources

About