Development and evaluation of PLA based hybrid block copolymeric nanoparticles for systemic delivery of pirarubicin as an anti-cancer agent

Anees, Mohd; Tiwari, Sachchidanand; Mehrotra, Neha; Kharbanda, Surender; Singh, Harpal

doi:10.1016/j.ijpharm.2022.121761

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…However, the tumor regression rates increased to 86.65% ± 2.6% and 94.36% ± 2.3% when using DOX NPs and PIRA NPs, respectively. Significantly, the use of polymers did not induce unnecessary non-targeted cardiac toxicity or myocardial atrophy (Anees et al, 2022) (Refer to Figure 6 for further details). 2023) also employed a hybrid-block copolymer nanoparticle system, PLA-mPEG/PLA-L61-PLA NPs, to simultaneously deliver the chemotherapy drug navitoclax and decitabine (DCB) for combined cancer therapy.…”

Section: Polylactic Acid (Pla)mentioning

confidence: 98%

Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Wang,

Xiao,

Guo

et al. 2023

Front. Bioeng. Biotechnol.

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Cancer presents a formidable threat to human health, with the majority of cases currently lacking a complete cure. Frequently, chemotherapy drugs are required to impede its progression. However, these drugs frequently suffer from drawbacks such as poor selectivity, limited water solubility, low bioavailability, and a propensity for causing organ toxicity. Consequently, a concerted effort has been made to seek improved drug delivery systems. Nano-drug delivery systems based on biodegradable polyesters have emerged as a subject of widespread interest in this pursuit. Extensive research has demonstrated their potential for offering high bioavailability, effective encapsulation, controlled release, and minimal toxicity. Notably, poly (ε-caprolactone) (PCL), poly (lactic-co-glycolic acid) (PLGA), and polylactic acid (PLA) have gained prominence as the most widely utilized options as carriers of the nano drug delivery system. This paper comprehensively reviews recent research on these materials as nano-carriers for delivering chemotherapeutic drugs, summarizing their latest advancements, acknowledging their limitations, and forecasting future research directions.

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Section: Polylactic Acid (Pla)mentioning

confidence: 98%

Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Wang,

Xiao,

Guo

et al. 2023

Front. Bioeng. Biotechnol.

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“…To evaluate the cytotoxic effect of the synthesized 3amino-1-indenone derivatives, in-vitro cell proliferation inhibition studies were performed. Triple negative breast cancer cells SUM-149 and MDA-MB-468 [21] were treated with two of the synthesized compounds, 3 a and 4 h. The biocompatibility of 3 a and 4 h was ascertained by treating them with mice fibroblast cells L929 (see SI, Page S31-S32). While both molecules displayed anti-cancer activity on both the cancerous cell lines, 3 a did not affect healthy cells.…”

Section: Biological Studiesmentioning

confidence: 99%

Photoredox Radical Cascade Cyclization of 2‐Alkynylarylnitriles in Visible Light: Direct Access to 3‐Amino‐1‐indenones

Rajput,

Garg,

Jain

2024

Adv Synth Catal

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A photoinduced direct synthesis of 3‐amino‐1‐indenones via radical cascade cyclization strategy is demonstrated. The methodology involves a domino reaction between 2‐alkynylarylnitrile and N‐aminopyridinium salt and captures the reactivity of in‐situ generated nitrogen‐centered radical (NCR) in visible light. Multiple bond‐forming events including C‐N, C‐C, and C‐O take place sequentially on 2‐alkynylarylnitrile enabling construction of 3‐amino‐1‐indenone core at room temperature in 35‐76% yields. A preliminary biological screening of synthesized compounds is indicative of their potent anti‐cancer property.

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“…However, long-term use of pirarubicin causes bone marrow suppression and severe cardiotoxicity. Anees et al (2022) developed pirarubicin encapsulated with biodegradable polymeric NPs to reduce off-target toxicity and enhance antitumor efficacy, which exhibited higher antitumor efficacy than free drugs in Ehrlich Ascites Carcinoma–bearing BALB/c mice. Treatment with free pirarubicin caused severe cardiotoxicity indicated by atrophy and hemorrhage in the myocardium, whereas no adverse effects on cardiac muscles was seen in mice treated with pirarubicin-encapsulated NPs.…”

Section: Antitumor Antibioticsmentioning

confidence: 99%

Will nanomedicine become a good solution for the cardiotoxicity of chemotherapy drugs?

Jiang

Yong-ming

et al. 2023

Front. Pharmacol.

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Cancer is one of the leading causes of death worldwide, and with the continuous development of life sciences and pharmaceutical technology, more and more antitumor drugs are being used in clinics to benefit cancer patients. However, the incidence of chemotherapy-induced cardiotoxicity has been continuously increasing, threatening patients’ long-term survival. Cardio-oncology has become a research hot spot, and the combination of nanotechnology and biomedicine has brought about an unprecedented technological revolution. Nanomaterials have the potential to maximize the efficacy and reduce the side effects of chemotherapeutic drugs when used as their carriers, and several nano-formulations of frequently used chemotherapeutic drugs have already been approved for marketing. In this review, we summarize chemotherapeutic drugs that are highly associated with cardiotoxicity and evaluate the role of nano-delivery systems in reducing cardiotoxicity based on studies of their marketed or R&D nano-formulations. Some of the marketed chemotherapy drugs are combined with nano-delivery systems that can effectively deliver chemotherapy drugs to tumors and cannot easily penetrate the endothelial barrier of the heart, thus decreasing their distribution in the heart and reducing the cardiotoxicity to some extent. However, many chemotherapy nanomedicines that are marketed or in R&D have not received enough attention in determining their cardiotoxicity. In general, nanomedicine is an effective method to reduce the cardiotoxicity of traditional chemotherapy drugs. However, cardiovascular complications in cancer treatment are very complex diseases, requiring the application of multiple measures to achieve effective management and prevention.

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Development and evaluation of PLA based hybrid block copolymeric nanoparticles for systemic delivery of pirarubicin as an anti-cancer agent

Cited by 6 publications

References 44 publications

Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Photoredox Radical Cascade Cyclization of 2‐Alkynylarylnitriles in Visible Light: Direct Access to 3‐Amino‐1‐indenones

Will nanomedicine become a good solution for the cardiotoxicity of chemotherapy drugs?

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