Development and Laboratory Testing of a Noninvasive Intracranial Focused Hyperthermia System

Functional Brain Imaging Using Non-Invasive Non-Ionizing Methods: Towards Multimodal and Multiscale Imaging

“…Considering the above, as well as the wide variety of potentially harmful agents that coexist in contemporary everyday life, entirely passive, non-invasive and painless assessment of brain function in living subjects constitutes a wishful perspective and scientific vision. Under this rationale, the functional imaging perspective of a novel passive microwave imaging device is being investigated during the past 7 years (Karanasiou et al, 2004(Karanasiou et al, , 2008Karathanasis et al, 2010;Gouzouasis et al, 2010). Microwave radiometry is an important scientific research and application area of microwave sensing because it provides a passive sensing technique for detecting naturally emitted electromagnetic radiation.…”

“…Both spatial resolution and detection depth provided by the system have been estimated through detailed theoretical analysis and validation experimental procedures using phantoms and animals (e.g. Karanasiou et al, 2004Karanasiou et al, , 2008Karathanasis et al, 2010;Gouzouasis et al, 2010). In the range 1.3-3.5 GHz, imaging of the head model areas placed at the ellipsoid's focus is feasible with a variety of detection depths (ranging from 2 to 4.5 cm) and spatial resolution (ranging from less than 1 cm to over 3 cm), depending on the frequency used.…”

Non-Invasive Microwave Radiometric System for Intracranial Applications: A Study Using the Conformal L-Notch Microstrip Patch Antenna

“…The applications of microwave radiometry in clinical medicine aim mainly at obtaining information about internal in-depth body temperature patterns by the non-traumatic measurement of natural thermal radiation from body tissues at low microwave frequencies. Knowledge of such internal body thermal patterns can assist clinical disease detection and diagnosis, e.g., as a noninvasive complement to the current computed tomography (CT) and magnetic resonance imaging (MRI) technologies [9], and may have a role in the monitoring of therapeutic processes [10], e.g., during hyperthermia [11].…”

“…Brain hyperthermia and hypothermia may also occur following pharmacological challenges. Since most physical and chemical processes governing neuronal activity are temperature-dependent, naturally occurring fluctuations of brain temperatures may have important functional consequences, affecting various neural functions [11]. It has been also suggested that Focused microwave radiometry may provide the capability of also detecting electrical conductivity variations at microwave frequencies of excitable cell clusters, such as in the case of brain tissues under certain psychophysiological conditions [12].…”

Ανάλυση Και Σχεδίαση Μικροκυματικών Μεταϋλικών Μέσων

“…Πρόκειται για ένα µη επεµβατικό σύστηµα το οποίο έχει αναπτυχθεί τα τελευταία χρόνια στο εργαστήριο µικροκυµάτων και οπτικών ινών του ΕΜΠ και µπορεί να χρησιµοποιηθεί τόσο για διαγνωστικούς όσο και για θεραπευτικούς σκοπούς [42][43][44]. Η µέθοδος θεραπείας που παρέχει το σύστηµα είναι η υπερθερµία, µία γνωστή τεχνική θεραπείας του καρκίνου, στην οποία η θερµοκρασία των ιστών που βρίσκονται εντός του όγκου αυξάνεται στην Παρατηρούµε ότι επιτυγχάνεται σηµαντική µείωση του ανακλώµενου ηλεκτρικού πεδίου επιβεβαιώνοντας την υπόθεση πως η παρουσία του γύρω από το µοντέλο θα βελτιώσει τη συνθήκη προσαρµογής στη διεπαφή αέρα-µοντέλου ανθρώπινου κεφαλιού.…”