Development and validation of a nomogram to predict cancer-specific survival in patients with hypopharyngeal squamous cell carcinoma treated with primary surgery

Wang, Ke; Xu, Xia; Xiao, Ruotao; Du, Danyi; Zhang, Hanqing; Lv, Zehong; Li, Xiangping; Li, Gang

doi:10.1177/03000605211067414

Cited by 4 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, age and clinical stage were independent prognostic factors for OS by multivariate COX analysis. The result aligns with the National Comprehensive Cancer Network (NCCN) guide, where the clinical stage is considered for patients’ stratification and treatment decisions [ 31 ]. We combined peripheral blood parameters with clinic factors to predict OS and improve prediction accuracy compared with the clinical model alone.…”

Section: Discussionmentioning

confidence: 58%

A Study of Peripheral Blood Parameters to Predict Response to Induction Chemotherapy and Overall Survival in Advanced Laryngeal Squamous Cell Carcinoma

et al. 2022

View full text Add to dashboard Cite

Purpose: the purpose of this study was to screen peripheral blood parameters and construct models predicting the prognosis and induction chemotherapy (IC) response in locally advanced laryngeal squamous cell carcinoma (LSCC) patients. Methods: A total of 128 stage III/IVa LSCC patients (who required a total laryngectomy) were enrolled in a retrospective study from January 2013 to September 2020 at Beijing Tongren Hospital of Capital Medical University. Among them, 62 patients received IC (IC group), and 66 patients immediately underwent a total laryngectomy (TL) after diagnosis (surgery group). Demographic information and peripheral blood parameters were collected for further analysis. The overall survival (OS), progression-free survival (PFS), and disease-specific survival (DSS) were compared between the two groups. The prognosis and survival were also compared between patients with laryngeal function preservation (LFP) and those with TL. Results: The Receiver Operating Characteristic (ROC) curve for IC response in the IC group showed that the AUC of the blood model based on the four peripheral blood parameters of fibrinogen (FIB), platelet (PLT), high-density lipoprotein cholesterol (HDL), and albumin (ALB) was significantly higher than the TNM stage model’s AUC (0.7932 vs. 0.6568). We constructed a nomogram blood model to predict IC response (C-Index = 0.793). Regarding the OS of all patients, an ROC analysis for overall survival, the Kaplan–Meier (K-M) method with a log-rank test, and multivariate analysis indicated age, clinical stage, FIB, and hemoglobin (HGB) were independent prognostic factors for the OS of LSCC patients. The blood–clinical logistic model (AUC = 0.7979) was constructed based on the four prognosis factors, which were superior to the blood (AUC = 0.6867) or clinical models (AUC = 0.7145) alone to predict OS. We constructed a nomogram model based on age, clinical stage, FIB, and HGB to predict OS for LSCC patients (C-Index = 0.792). Besides this, there were no significant differences in OS, PFS, and DSS between IC and surgery groups or LFP and TL groups. Conclusion: Peripheral blood parameters help predict IC response and overall survival. Furthermore, induction chemotherapy significantly improves laryngeal function preservation without lowering the survival prognosis.

show abstract

Section: Discussionmentioning

confidence: 58%

A Study of Peripheral Blood Parameters to Predict Response to Induction Chemotherapy and Overall Survival in Advanced Laryngeal Squamous Cell Carcinoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…As it is known that compared with the SEER stage, nomogram has the following advantages: (1) By combining various independent risk factors according to the patient's condition, it allows for a more intuitive assessment and individualization of the patient's prognosis (21). ( 2) It quantifies the possibility of OS and CSS in patients, permitting a more precise prognostic evaluation (22). Therefore, for the first time, the prognostic nomograms were developed for adult RS patients to obtain personalized and accurate prognostic predictions in this study.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a prognostic nomogram for adult patients with renal sarcoma: A retrospective study based on the SEER database

Zhu

Mao²,

Zhang³

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

BackgroundRenal sarcoma (RS) is rarely seen in clinical practice. The purpose of this study was to develop a prognostic nomogram model, which could predict the probability of overall survival (OS) and cancer-specific survival (CSS) in adult patients with RS.MethodsPatients diagnosed with RS were recruited from the SEER database between 2004 and 2015, and randomized to two cohorts: the training cohort and the validation cohort. Uni- and multivariate Cox regression analyses in the training cohort were used to screen independent prognostic factors for OS and CSS. Prognostic nomograms for OS and CSS were created separately for adult RS patients based on independent risk factors. The area under the receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA) were used to validate the nomograms.ResultsA total of 232 eligible patients were recruited, including 162 in the training cohort and 70 in the validation cohort. Sex, histological type, SEER stage, and surgery were independent prognostic factors for OS, while histological type, SEER stage, surgery, chemotherapy were independent prognostic factors for CSS. Based on the above independent prognostic factors, prognostic nomograms for OS and CSS were created respectively. In the training cohort, the AUCs of the nomograms for OS and CSS were 0.742 and 0.733, respectively. In the validation cohort, the AUCs of the nomograms for OS and CSS were 0.837 and 0.758, respectively. The calibration curves of the nomograms showed high consistencies between the predicted and actual survival rates. Finally, the DCA demonstrated that the nomograms in the wide high-risk threshold had a higher net benefit than the SEER stage.ConclusionA prognostic nomogram for renal sarcoma was created and validated for reliability and usefulness in our study, which assisted urologists in accurately assessing the prognosis of adult RS patients.

show abstract

“…Another SEER based study enrolled 1144 HPSCC patients treated with surgery between 2004 and 2015. No significant difference in cancer specific survival was observed between whites and blacks, or between white and other races [14]. Using the SEER database, another study recruited 3,172 HPSCC patients aged 60 and above years old diagnosed from 2004 to 2018.…”

Section: Plos Onementioning

confidence: 99%

“…Several recent studies have built statistical models to predict the prognosis of HPSCC [10][11][12][13][14][15][16]. Race is found to be one of the independent factors correlated with survival in patients with HPSCC in some studies [10][11][12][13], in which black patients were shown to have worse survival compared to whites or other races [10][11][12][13]17].…”

Section: Introductionmentioning

confidence: 99%

“…Race is found to be one of the independent factors correlated with survival in patients with HPSCC in some studies [10][11][12][13], in which black patients were shown to have worse survival compared to whites or other races [10][11][12][13]17]. (However, other studies reported no racial disparity in the survival of patients with HPSCC [14][15][16]. Clinicopathological features of HPSCC among individual races have not been well investigated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Updated racial disparities in incidence, clinicopathological features and prognosis of hypopharyngeal squamous carcinoma in the United States

Liang

Wang

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Objective This study was to determine the racial disparities in incidence, clinicopathological features and prognosis of hypopharyngeal squamous cell carcinoma (HPSCC) in the US. Methods The National Program of Cancer Registries and Surveillance, Epidemiology, and End Results (SEER) database was used to determine racial disparity in age adjusted incidence rate (AAIR) of HPSCC and its temporal trend during 2004–2019. Using the separate SEER 17 database, we further evaluated racial disparity in clinicopathological features, and in prognosis using Kaplan-Meier curves and Cox proportional hazard models. Results HPSCC accounted for 95.8% of all hypopharyngeal cancers and occurred much more frequently in males. Its incidence decreased in both male and females, in male non-Hispanic white (NHW), non-Hispanic black (NHB) and Hispanic as well as female NHW and NHB during the study period. NHB had the highest, whereas non-Hispanic Asian or Pacific Islanders (API) had comparable and the lowest incidence in both males and females. Among 6,172 HPSCC patients obtained from SEER 17 database, 80.6% were males and 83.9% were at the advanced stages III/IV. Five-year cancer specific and overall survival rates were 41.2% and 28.9%, respectively. NHB patients were more likely to be younger, unmarried, from the Southern region, larger sized tumor, and at the stage IV, but less likely to receive surgery. They also had higher proportions of dying from HPSCC and all causes. Multivariate analyses revealed that NHB with HPSCC at the locally advanced stage had both significantly worse cancer specific and overall survival compared with NHW, but not at early stage (I/II) or distant metastatic stage. Hispanic patients had significantly better prognosis than NHW at locally advanced and metastatic stages. NHW and API had comparable prognoses. Conclusions HPSCC displays continuously decreased incidence and racial disparity. The majority of the disease is diagnosed at the advanced stage. NHB have the highest burden of HPSCC and a worse prognosis. More studies are needed to curtail racial disparity and improve early detection.

show abstract

Development and validation of a nomogram to predict cancer-specific survival in patients with hypopharyngeal squamous cell carcinoma treated with primary surgery

Cited by 4 publications

References 31 publications

A Study of Peripheral Blood Parameters to Predict Response to Induction Chemotherapy and Overall Survival in Advanced Laryngeal Squamous Cell Carcinoma

A Study of Peripheral Blood Parameters to Predict Response to Induction Chemotherapy and Overall Survival in Advanced Laryngeal Squamous Cell Carcinoma

Development and validation of a prognostic nomogram for adult patients with renal sarcoma: A retrospective study based on the SEER database

Updated racial disparities in incidence, clinicopathological features and prognosis of hypopharyngeal squamous carcinoma in the United States

Contact Info

Product

Resources

About